Abstract: The present disclosure relates to thermal contrast therapy devices, treatment methods for providing thermal contrast therapy, and systems for providing and managing thermal contrast therapy treatments. The thermal contrast therapy devices disclosed herein are configured to provide a sequence of alternating cooling periods and heating periods to one or more areas of a patient's body. A thermal contrast therapy device may comprise a source of hot fluid, a source of cold fluid, and one or more pumps configured to circulate fluid through one or more treatment pads in fluid communication with the device. The thermal contrast therapy devices disclosed herein are configured to rapidly and efficiently transition between alternating cooling periods and heating periods.