Abstract: A method of accelerating cellular maturation is provided, the method including impairing the activity of developmental transcriptional condensates at an intermediate stage of a cell lineage. Specifically, Sox6 gene expression is inhibited to accelerate maturation of oligodendrocyte precursors, such as oligodrendrocyte progenitor cells (OPCs), into fully mature myelin-producing oligodendrocytes.

Abstract: Embodiments predict response to neoadjuvant chemotherapy (NAC) in breast cancer (BCa) from pre-treatment dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).

Abstract: A diagnostic device is described herein that can be used to perform magneto-optical detection and discernment of crystals within a biofluid sample. A magnetic field can be applied by the diagnostic device in a direction relative to light traveling through the sample. The presence of a crystal can be determined based on the magneto-optical properties of the sample. The detected crystal can be one of two similar crystal types that may be in the biofluid sample. The two similar crystal types can exhibit different magneto-optical properties under a magnetic field in a different direction. Accordingly, the type of crystal can be discerned by applying the magnetic field in the different direction as light travels through the sample. Discernment of the type of crystal can lead to diagnosis of the particular disease condition and subsequent proper treatment of the disease condition.

Abstract: A method of treating a PSMA expressing cancer in a subject includes (a) administering to the subject a PSMA-targeted phthalocyanine conjugate compound having the formula (I), (b) detecting the PSMA-targeted phthalocyanine compound bound to and/or complexed with the prostate cancer cells to determine the location and/or distribution of the prostate cancer cells in the subject, (c) surgical resection of the detected cancer, and (d) irradiating the PSMA-targeted phthalocyanine compound at the site of surgical resection, thereby inducing the cytotoxic effects of the phthalocyanine compound on residual prostate cancer cells following surgical resection.

Abstract: A method for free-breathing abdominal magnetic resonance fingerprinting (MRF) includes applying a pilot tone (PT) RF signal in an MRI system environment using a PT RF signal source, acquiring MRF data from a region of interest in subject using free-breathing MRF pulse sequence and acquiring PT navigator signals based on the applied PT RF signal. The PT navigator signals are associated with a plurality of respiratory states and are encoded with acquired MRF data. The method further includes generating images for each of the plurality of respiratory states based on MRF data and the PT navigator signals. For each respiratory state, the generated images for the respiratory state are compared to a respiratory state MRF dictionary associated with the respiratory state to determine tissue property of the MRF data associated with the respiratory state. A quantitative parameter map may be generated for the determined tissue properties for each respiratory state.

Abstract: A modified nerve cuff electrode is designed to enhance the stability of neural recording and/or nerve stimulation. Any nerve cuff electrode includes a nerve cuff and a plurality of electrodes within the nerve cuff. While traditional nerve cuff electrodes have every one of the plurality of electrode contacts on the inner surface of the nerve cuff, in the modified nerve cuff electrode each of an inner surface and an outer surface of the nerve cuff has at least one electrode contact. The at least one electrode contact on the outer surface can be electrically isolated from the peripheral nerve to provide a stable reference or ground during recording or a stable pathway for a return current during stimulation to enhance the stability of the recording or the stimulation.

Abstract: The present disclosure describes, in part, compositions comprising derivatives and methods of using the same in prevention or treatment of viral infections in a subject.

Abstract: A method of producing plant virus-like particles includes freeze drying an aqueous solution of plant virus particles to produce a substantially RNA-free plant virus-like particles.

Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

Abstract: A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of a compound, the small molecule having a general formula: A-L-X—Z (I).

Abstract: A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted.

Abstract: A method for preventing or treating a tissue injury and/or promoting tissue repair in a subject in need thereof, includes administering to the subject a therapeutically effective amount of an ADH inhibitor, AKR inhibitor, SCoR inhibitor, and/or PKM2 inhibitor.

Abstract: A synthetic lentiviral vector construct comprises a genomic RNA packaging enhancer (GRPE) element and lentiviral nucleic acid sequences sufficient for reverse transcription and packaging in a host cell.

Abstract: Embodiments include accessing an image of a region of tissue demonstrating cancerous pathology; detecting a plurality of cells represented in the image; segmenting a cellular nucleus of a first member of the plurality of cells and a cellular nucleus of at least one second, different member of the plurality of cells; extracting a set of nuclear morphology features from the plurality of cells; constructing a feature driven local cell graph (FeDeG) based on the set of nuclear morphology features and a spatial relationship between the cellular nuclei using a mean-shift clustering approach; computing a set of FeDeG features based on the FeDeG; providing the FeDeG features to a machine learning classifier; receiving, from the machine learning classifier, a classification of the region of tissue as a long-term or a short-term survivor, based, at least in part, on the set of FeDeG features; and displaying the classification.

Abstract: A pressure sensor array can be used to record a pressure distribution in gait analysis and/or tactile sensing applications. The pressure sensor array can include a piezo-resistive material and a uniform distribution of a plurality of flexible circuits. Each of the plurality of flexible circuits comprise at least one wire connecting an internal portion of a respective flexible circuit to a common port. A device housing the pressure sensor array can be customized to a size and used for a gait analysis and/or tactile sensing application. The arrangement of the wiring permits partial sensors to be used as part of the pressure sensor array during the gait analysis and/or tactile sensing application.

Abstract: Systems, methods, and media for displaying interactive augmented reality presentations are provided. In some embodiments, a system comprises: a plurality of head mounted displays, a first head mounted display comprising a transparent display; and at least one processor, wherein the at least one processor is programmed to: determine that a first physical location of a plurality of physical locations in a physical environment of the head mounted display is located closest to the head mounted display; receive first content comprising a first three dimensional model; receive second content comprising a second three dimensional model; present, using the transparent display, a first view of the first three dimensional model at a first time; and present, using the transparent display, a first view of the second three dimensional model at a second time subsequent to the first time based one or more instructions received from a server.

Abstract: A method of treating pulmonary metastasis of osteosarcoma cells (pOSs) in a subject in need thereof includes administering to the subject a therapeutically effective amount of an agent that interferes with VCAM-1/?4?1 signaling between pOSs expressing VCAM-1 and pulmonary macrophages (MACs) expressing ?4?1.

Abstract: Disclosed herein are methods and compositions useful in reducing inflammation, reducing inflammatory exudates, enhancing epithelial tissue generation or regeneration, and/or reducing mean pulmonary artery pressure in the lungs of a subject in need thereof. In particular, the compositions comprise vitamin D, an analog, or metabolite thereof, and the methods include administering the composition to a subject in need thereof. In some embodiments, the subject is suffering from an infection, such as a viral infection, which affects the lungs. In some embodiments, the viral infection comprises SARS-CoV-2.

Abstract: In an example, a system includes a plurality of acoustically coupled nodes. Each of the nodes includes a transducer, a communication circuit and a controller. The transducer is adapted to be mechanically coupled to a medium. The communication circuit is coupled to the transducer to send and receive acoustic signals via the medium according to at least one communication parameter. The controller is to adaptively configure the at least one communication parameter of the communication circuit based on an acoustic signal received from at least one other of the nodes.

Abstract: Embodiments discussed herein facilitate determination of a response to treatment and/or a prognosis for a tumor based at least in part on features of tumor-associated vasculature (TAV). One example embodiment is a method, comprising: accessing a medical imaging scan of a tumor, wherein the tumor is segmented on the medical imaging scan; segmenting tumor-associated vasculature (TAV) associated with the tumor based on the medical imaging scan; extracting one or more features from the TAV; providing the one or more features extracted from the TAV to a trained machine learning model; and receiving, from the machine learning model, one of a predicted response to a treatment for the tumor or a prognosis for the tumor.