Patents Assigned to Case Western Reserve University
  • Patent number: 10937391
    Abstract: Systems, methods, and media for displaying interactive augmented reality presentations are provided. In some embodiments, a system comprises: a plurality of head mounted displays, a first head mounted display comprising a transparent display; and at least one processor, wherein the at least one processor is programmed to: determine that a first physical location of a plurality of physical locations in a physical environment of the head mounted display is located closest to the head mounted display; receive first content comprising a first three dimensional model; receive second content comprising a second three dimensional model; present, using the transparent display, a first view of the first three dimensional model at a first time; and present, using the transparent display, a first view of the second three dimensional model at a second time subsequent to the first time based one or more instructions received from a server.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: March 2, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Mark A. Griswold, Erin Henninger, Jeff Mlakar, Henry Eastman, Robert Gotschall, Catherine Sue Shick, Galen Tingle
  • Patent number: 10937159
    Abstract: Embodiments discussed herein relate to accessing a digitized image associated with a patient of tissue demonstrating breast cancer pathology; segmenting a tumor region represented in the digitized image; segmenting collagen fibers represented in the tumor region; computing collagen vectors based on the segmented collagen fibers; generating an orientation co-occurrence matrix based on the collagen vectors; computing a collagen fiber orientation disorder feature based on the co-occurrence matrix; upon determining that the collagen fiber orientation feature exceeds a threshold value: generating a prognosis of the region of tissue as unlikely to experience breast cancer recurrence; upon determining that the collagen fiber orientation feature is less than or equal to the threshold value: generating a prognosis of the region of tissue as likely to experience breast cancer recurrence; classifying the patient as high-risk of recurrence or low-risk of recurrence based, at least in part, on the prognosis; and displayin
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: March 2, 2021
    Assignee: Case Western Reserve University
    Inventors: Anant Madabhushi, Haojia Li
  • Patent number: 10933093
    Abstract: A method of generating a CD4+FoxP3+ Treg cell, the method includes administering at least one complement antagonist to a naive CD4+ T cell at an amount effective to substantially inhibits C3a receptor (C3aR) and/or C5a receptor (C5aR) signal transduction in the CD4+ T cell, induce TGF-?1 expression of the CD4+ T cell, and induce differentiation of the of the naive CD4+ T cell into a CD4+FoxP3+ Treg cell.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: March 2, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: M. Edward Medof, Feng Lin, Michael G. Strainic
  • Patent number: 10935513
    Abstract: A sensor for detecting volatile organic compounds (VOCs) includes a substrate, a working electrode formed on a surface of the substrate, a counter electrode formed on the surface of the substrate, a dielectric layer covering a portion of the working electrode and counter electrode and defining an aperture exposing other portions of the working electrode and counter electrode.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: March 2, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Chung Chiun Liu
  • Patent number: 10935549
    Abstract: The present invention provides biomarkers, methods and kits for diagnosing latent tuberculosis (TB) in a subject exposed to TB, and methods and kits for monitoring the effectiveness of treatment for latent TB.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: March 2, 2021
    Assignees: Caption Biosciences Inc., Case Western Reserve University
    Inventors: Eustache Paramithiotis, W. Henry Boom, Charles Bark
  • Patent number: 10925980
    Abstract: A molecular probe includes the following formula: P-L-C wherein P is a EDB-FN targeting peptide, C is a contrast agent; and L is a non-peptide linker that covalently links the peptide to the contrast agent.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: February 23, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Zheng-Rong Lu, Zheng Han
  • Patent number: 10918312
    Abstract: This disclosure relates to systems and methods to analyze gait, balance or posture information extracted from data collected by one or more wearable and connected sensor devices with sensors embedded therewithin. The embedded sensors include a three-axis accelerometer, a three-axis gyroscope and an array of pressure sensors. Sensor data detected by the sensors can be received by a mobile computing device, which can analyze the sensor data to identify a pattern related to gait, balance or posture within the sensor data; and apply a statistical/machine learning-based classification to the pattern related to gait, balance or posture to assign a clinical parameter to the pattern characterizing a risk of a slip, trip and fall event.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: February 16, 2021
    Assignees: CASE WESTERN RESERVE UNIVERSITY, THE RESEARCH FOUNDATION FOR STATE UNIVERSITY OF NEW YORK
    Inventors: Ming-Chun Huang, Wenyao Xu
  • Patent number: 10921408
    Abstract: Embodiments discussed herein facilitate generating a quantitative population atlas of tumor progression (TP) versus pseudo-progression (PsP) in Glioblastoma (GBM). A first set of embodiments discussed herein relates to generating a quantitative population atlas of TP versus PsP based on a plurality of multi-parametric (mpMRI) studies of a population of patients demonstrating GBM. A second set of embodiments discussed herein relates to computing a probability that a patient will experience PsP or TP based on a DICE analysis of a mapping of a diagnostic mpMRI study associated with the patient into the quantitative population atlas space.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: February 16, 2021
    Assignee: Case Western Reserve University
    Inventors: Pallavi Tiwari, Marwa Ismail, Anant Madabhushi
  • Patent number: 10918610
    Abstract: The invention is a method of treating a subject with primary progressive or secondary progressive multiple sclerosis. The method comprises administering an effect amount of Cis-N-cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)prop-2-enylamine or a pharmaceutically acceptable salt thereof to the subject.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 16, 2021
    Assignee: Case Western Reserve University
    Inventors: Paul Tesar, Drew Adams, Steven B. Landau
  • Patent number: 10913837
    Abstract: Nano-emulsions and nano-latexes comprising functionalized cellulose nanocrystals (CNCs) as a surfactant that impacts the stability and size of the emulsion droplets of oil-in water emulsions. Stable emulsions can be accessed by adding a desired organic, non-water soluble molecule as the oil phase to an aqueous CNC suspension followed by agitation. Depending on the functionalization of the CNCs, their hydrophilic/hydrophobic balance can be modified, which allows the ability to control the stability and droplet size of the emulsion. Methods for producing nano-emulsions and nano-latexes, when the oil phase contains a polymerizable monomer, are disclosed.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: February 9, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Stuart J. Rowan, Yefei Zhang
  • Patent number: 10914682
    Abstract: A hyperspectral Raman imaging system having the ability to focus on excitation laser beam over a relatively wide field of view due to the use of a lens array, in particular a microlens array. Hyperspectral selection is provided in one embodiment through the use of dual-axis controlled dielectric filtration. Methods for analyzing materials with the system are disclosed. The device or system can be used in generally any application where investigation of materials is required.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: February 9, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Ozan Akkus, Shan Yang
  • Patent number: 10905762
    Abstract: A composition for treating a disorder in a subject includes a polyethylene glycolylated (PEGylated) nanoparticle, at least one hydrophobic therapeutic agent coupled to the surface of the nanoparticle; and at least one targeting moiety coupled to polyethylene glycol of the nanoparticle for targeting the composition to a cell associated with disorder.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: February 2, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: James Basilion, Clemens Burda
  • Patent number: 10905778
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: February 2, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jeffery M. Coller, Thomas Sweet
  • Patent number: 10908247
    Abstract: A method for characterizing a tissue in a subject using magnetic resonance fingerprinting (MRF) includes acquiring MRF data from a tissue in a subject using a magnetic resonance imaging (MRI) system, comparing the MRF data to a MRF dictionary to identify quantitative values of at least one tissue property for the MRF data, generating a quantitative map based on the quantitative values of the at least one tissue property, identifying at least one region of interest on the quantitative map, determining at least one texture feature of the at least one region of interest of the quantitative map, characterizing the tissue in the at least one region of interest based on the at least one texture feature and generating a report indicating the characterization of the tissue based in the at least one texture feature.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: February 2, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Debra McGivney, Samuel Frankel, Ananya Panda, Chaitra Badve, Vikas Gulani
  • Patent number: 10898550
    Abstract: A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: January 26, 2021
    Assignees: CASE WESTERN RESERVE UNIVERSITY, VERSITECH LIMITED
    Inventors: Jerry Silver, Bradley T. Lang, Jared M. Cregg, Yi-Lan Weng, Heng Li, Wutian Wu
  • Patent number: 10898089
    Abstract: Example apparatus and methods improve magnetic resonance fingerprinting (MRF) by performing MRF with optimized spatial encoding, parallel imaging, and utilization of field inhomogeneities. Multi-echo radial trajectories and spiral trajectories may acquire data according to sampling schemes based on models of charge distribution on a sphere. Non-uniform sampling schemes may account for differences in detector coil performance. Field inhomogeneities provide spatial information that enhances the spatial separation of an MRF signal and facilitates unaliasing pixels. The field inhomogeneity may be manipulated. An MRF pulse sequence may include frequency selective RF pulses that are determined by the field inhomogeneities. Inhomogeneities combined with selective RF pulses result in higher acquisition efficiency.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: January 26, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Vikas Gulani, Mark Griswold, Dan Ma, Alice Yang
  • Patent number: 10902256
    Abstract: Embodiments include controlling a processor to perform operations, the operations comprising: accessing a digitized image of a region of tissue demonstrating non-small cell lung cancer (NSCLC), detecting a member of a plurality of cellular nuclei represented in the image; classifying the member of the plurality of cellular nuclei as a tumor infiltrating lymphocyte (TIL) nucleus or non-TIL nucleus; extracting spatial TIL features from the plurality of cellular nuclei, including a first subset of features based on the spatial arrangement of TIL nuclei, and a second, different subset of features based on the spatial relationship between TIL nuclei and non-TIL nuclei; generating a set of graph interplay features based on the set of spatial TIL features; providing the set of graph interplay features to a machine learning classifier; receiving, from the machine learning classifier, a probability that the region of tissue will respond to immunotherapy, based, at least in part, on the set of graph interplay features;
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: January 26, 2021
    Assignee: Case Western Reserve University
    Inventors: Anant Madabhushi, Xiangxue Wang, Cristian Barrera, Vamsidhar Velcheti
  • Patent number: 10902591
    Abstract: Embodiments access a pre-neoadjuvant chemotherapy (NAC) radiological image of a region of tissue demonstrating breast cancer (BCa), the region of tissue including a tumoral region, the image having a plurality of pixels; extract a set of patches from the tumoral region; provide the set of patches to a convolutional neural network (CNN) configured to discriminate tissue that will experience pathological complete response (pCR) post-NAC from tissue that will not; receive, from the CNN, a pixel-level localized patch probability of pCR; compute a distribution of predictions across analyzed patches based on the pixel-level localized patch probability; classify the region of tissue as a responder or non-responder based on the distribution of predictions, and display the classification. Embodiments may further generate a probability mask based on the pixel-level localized patch probability; and generate a heatmap of likelihood of response to NAC based on the probability mask and the pre-NAC radiological image.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: January 26, 2021
    Assignee: Case Western Reserve University
    Inventors: Anant Madabhushi, Nathaniel Braman, Andrew Janowczyk, Kavya Ravichandran
  • Patent number: 10883109
    Abstract: A synthetic cDNA which encodes a protein wherein at least one optimal or non-optimal codon in a wild type DNA encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: January 5, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jeffery M. Coller, Kristian E. Baker
  • Patent number: 10881633
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: January 5, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Benjamin Gaston, Stephen Lewis