Patents Assigned to Case Western Reserve University
  • Patent number: 11318300
    Abstract: Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: May 3, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Niloy Bhadra, Narendra Bhadra, Kevin L. Kilgore, Scott Lempka, Tina Vrabec, Manfred Franke
  • Patent number: 11321842
    Abstract: Embodiments discussed herein facilitate determination of tumor mutation status based on context and spatial information. One example embodiment can access a MRI scan of a tumor comprising voxels; extract radiomic feature(s) from the voxels; generate a spatial feature descriptor indicating probabilities the tumor has a first mutation status and a second mutation status, based on the MRI scan, a first population atlas for the first mutation status, and a second population atlas for the second mutation status; provide the radiomic feature(s) and the spatial feature descriptor to a machine learning model; and receive, via the machine learning model, a map indicating, for each voxel of the voxels, a probability of the first mutation status for that voxel and a probability of the second mutation status for that voxel, wherein the map is based at least on the one or more radiomic features and the spatial feature descriptor.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: May 3, 2022
    Assignee: Case Western Reserve University
    Inventors: Pallavi Tiwari, Anant Madabhushi, Marwa Ismail, Niha Beig, Prateek Prasanna
  • Patent number: 11314953
    Abstract: This disclosure relates to tagging of materials and objects and analysis for authentication thereof. An example method includes analyzing separately a number of locations distributed across a given surface of a solid object according to one or more analysis technologies to determine feature data for each of the locations. The feature data are indicative of a respective chemical property and/or mechanical property of the solid object at each of the locations, corresponding to a feature tag, and the feature data depend on the one or more analysis technologies. The method also includes determining a tag signature for the solid object based on the feature data determined for each of the locations.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: April 26, 2022
    Assignees: CASE WESTERN RESERVE UNIVERSITY, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Swarup Bhunia, Naren Vikram Masna, Soumyajit Mandal
  • Patent number: 11313931
    Abstract: A method for quantifying T1, T2 and resonance frequency simultaneously using magnetic resonance fingerprinting (MRF) includes accessing an MRF dictionary using a magnetic resonance imaging (MRI) system. The MRF dictionary is generated by simulating signal evolutions that include associated off-resonance effects for each signal evolution. The method further includes acquiring MRF data from a region of interest in a subject using the MRI system and a MRF pulse sequence having a plurality of radio frequency (RF) excitations and a readout associated with each RF excitation. Each readout includes a plurality of segments and each segment is used to generate a time frame. The method also include comparing the MRF data to the MRF dictionary to identify a plurality of parameters including T1, T2 and resonance frequency for the MRF data and generating a report indicating the at least one of the plurality of parameters of the MRF data.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: April 26, 2022
    Assignee: Case Western Reserve University
    Inventors: Yuchi Liu, Jesse Hamilton, Nicole Seiberlich, Mark A. Griswold
  • Patent number: 11306406
    Abstract: Electrochemically aligned and compacted molecules, nanoparticles and microparticles with ampholytic nature, such as collagen, elastin, keratin and charged nanoparticle materials, methods of making and using the materials and associated production-related devices. In one embodiment, a device for producing continuous electrochemically aligned strands, threads or fibers is disclosed. In a further embodiment, fabrication of compositionally and geometrically complex anatomical forms by 3D-electrochemical compaction of biomolecules is disclosed. In yet another embodiment, methods for fabricating patterned lattice structures, in particular having controlled pore size and morphology, and the lattice structures themselves are also disclosed.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: April 19, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Ozan Akkus, Vipuil Kishore, Mousa Younesi, Anowarul Islam
  • Patent number: 11295112
    Abstract: Embodiments discussed herein facilitate training deep learning models to generate synthetic versions of histological texture features and employing such deep learning models. One example embodiment is an apparatus configured to convert a stained histological image to grayscale; extract patches from the grayscale image; for each patch of the plurality of patches: provide that patch to a deep learning model trained to generate a synthetic version of a texture feature; and obtain an associated patch from the deep learning model that indicates an associated value of the synthetic version of the histology texture feature for each pixel of that patch; and merge the associated patches for each patch of the plurality of patches to generate an associated feature map for the stained histological image, wherein the associated feature map indicates the associated value of the synthetic version of the histology texture feature for each pixel of the plurality of pixels.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: April 5, 2022
    Assignee: Case Western Reserve University
    Inventors: Cheng Lu, Anant Madabhushi, Khoi Le
  • Patent number: 11291832
    Abstract: Embodiments discussed herein facilitate identification of a target area within a region of a brain for stimulation via one or more BS (Brain Stimulation) electrodes. One example embodiment comprises generating, based on radiological imaging of a region of a brain of a patient and BS electrode lead(s), a patient-specific anatomical model of the region and lead(s); populating the patient-specific anatomical model with neuron models based on associated neuronal densities of at least one of the region or one or more sub-regions of the region; constructing a patient-specific local field potential (LFP) model of the region based on the patient-specific anatomical model and location(s)/orientation(s) of the one or more BS electrode leads; and identifying, via the patient-specific LFP model of the region, a target area within the region for at least one of monitoring or treatment of a medical condition via the one or more BS electrode leads.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: April 5, 2022
    Assignee: Case Western Reserve University
    Inventors: Cameron McIntyre, Nicholas Maling, Scott Lempka
  • Patent number: 11285660
    Abstract: This disclosure relates to a method of making a fluoropolymer object. The method may include providing a substrate including fluoropolymer comprising units derived from monomers M1, M2 and M3, wherein: M1 is a vinylidene fluoride; M2 is a monomer of formula (I): CX1X2?CX3X4, wherein each of X1, X2, X3 and X4 is independently selected from H, Cl and F, and wherein at least one of X1, X2, X3 and X4 is F; M3 is a monomer of formula (II): CY1Y2?CY3CF3, wherein each of Y1, Y2 and Y3 is independently selected from H, Cl, F, Br, I and alkyl groups comprising from 1 to 3 carbon atoms which are optionally partly or fully halogenated; and stretching the substrate.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: March 29, 2022
    Assignees: Arkema France, Case Western Reserve University
    Inventors: Thibaut Soulestin, Lei Zhu
  • Patent number: 11284849
    Abstract: Methods and apparatus for grading coronary calcium, including an example apparatus that includes a set of logics and a memory that stores a set of radiographic images. The set of logics includes an image acquisition logic that acquires a set of radiographic images of a region of tissue, the set of radiographic images including a low-energy reference x-ray image and a higher-energy floating x-ray image, a registration logic that produces a set of registered images from a plurality of members of the set of radiographic images, an enhancement logic that produces a set of calcium-enhanced images from the set of registered images, a post-enhancement logic that produces a bone image from the set of calcium-enhanced images, and a grading logic that computes a coronary heart disease prediction score based, at least in part, on the bone image and a set of features extracted from the bone image.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: March 29, 2022
    Assignee: Case Western Reserve University
    Inventors: David Wilson, Robert Gilkeson, Di Wen
  • Patent number: 11284851
    Abstract: Embodiments access a set of radiological images acquired from a population of subjects, where a member of the set of radiological images includes a left atrium (LA) region; construct a statistical shape differential atlas from the images; generate a template LA model from the statistical shape differential atlas, where the template LA model includes a site of interest (SOI); acquire a pre-ablation radiological image of a region of tissue in a patient demonstrating atrial fibrillation (AF) pathology; generate a patient LA model from the pre-ablation image; compute a deformation field that registers the SOI to the patient LA model using deformable registration; compute a patient feature vector based on the deformation field; generate an AF probability score for the patient based on the feature vector; generate a classification of the patient based, at least in part, on the AF probability score; and display the classification or the AF probability score.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: March 29, 2022
    Assignee: Case Western Reserve University
    Inventors: Anant Madabhushi, Thomas Atta-Fosu, Soumya Ghose
  • Patent number: 11273236
    Abstract: A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: March 15, 2022
    Assignees: CASE WESTERN RESERVE UNIVERSITY, WORCESTER POLYTECHNIC INSTITUTE
    Inventors: Eben Alsberg, Anna D. Dikina, Marsha W. Rolle, Hannah A. Strobel
  • Patent number: 11260127
    Abstract: A system for delivering a therapeutic agent to cell or tissue of a subject includes a mesoporous silica iron oxide nanoparticle with one or more therapeutic agents that are contained in a mesoporous silica layer of the nanoparticle and a remote radiofrequency (RF) energy source for applying RF energy to the nanoparticle effective to release the one or more therapeutic agents from the nanoparticle by mechanical tumbling and/or vibration of the nanoparticle, wherein release of the one or more therapeutic agents not caused by a hyperthermic response of the nanoparticle to the RF energy.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: March 1, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Efstathios Karathanasis, Watuthentrige Pubudu M. Peiris, Vindya Perera, Lisa Bauer
  • Patent number: 11260121
    Abstract: A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: March 1, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Nicole F. Steinmetz, Amy M. Wen, Steven Fiering, Patrick H. Lizotte
  • Patent number: 11253489
    Abstract: A method of treating an ocular disorder in a subject in need thereof includes administering to the subject a therapeutically effective amount of a retinal sequestering compound of formula (I).
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: February 22, 2022
    Assignees: CASE WESTERN RESERVE UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS
    Inventors: Krzysztof Palczewski, Philip Kiser, Jianye Zhang, Mohsen Badiee, Gregory Tochtrop
  • Patent number: 11253610
    Abstract: Anti-lymphoma plant virus particles are described. The anti-lymphoma plant virus particles include a filamentous or rod-shaped plant virus particle linked to an antimitotic agent. A therapeutically effective amount of an anti-lymphoma plant virus particle can be administered to a subject to provide a method of treating lymphoma.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: February 22, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Nicole F. Steinmetz
  • Patent number: 11255811
    Abstract: A sensor for the detection of lead includes a substrate, a working electrode formed on a surface of the substrate, a counter electrode formed on the surface of the substrate, a dielectric layer covering a portion of the working electrode and counter electrode and defining an aperture exposing other portions of the working electrode and counter electrode. The working electrode includes a metalized film with working surface and a monolayer (or bilayer) of bismuth deposited on the working surface by underpotential deposition.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: February 22, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Chung Chiun Liu, Yifan Dai
  • Patent number: 11246956
    Abstract: A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: February 15, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Jonathan Pokorski
  • Patent number: 11241190
    Abstract: Embodiments discussed herein facilitate predicting response to therapy in Crohn's disease. A first set of embodiments discussed herein relates to accessing a radiological image of a region of tissue demonstrating Crohn's disease associated with a patient; defining a mesenteric fat region by segmenting mesenteric fat represented in the radiological image; extracting a set of radiomic features from the mesenteric fat region; providing the set of radiomic features to a machine learning classifier configured to compute a probability of response to therapy in Crohn's disease based, at least in part, on the set of radiomic features; receiving, from the machine learning classifier, a probability that the region of tissue will respond to therapy; generating a classification of the patient as a responder or non-responder based, at least in part, on the probability; and displaying the classification.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: February 8, 2022
    Assignee: Case Western Reserve University
    Inventors: Satish Viswanath, Iulia Barbur
  • Patent number: 11234751
    Abstract: Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optical Coherence Tomography (OCT) are described. One example method includes acquiring an OCT signal from a Region Of Interest (ROI) in an ablated material. The example method may also include determining whether a lesion was formed by the ablation by analyzing optical properties of the ROI as recorded in the OCT signal.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: February 1, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Andrew M. Rollins, Christine P. Fleming
  • Patent number: 11236345
    Abstract: A synthetic nucleic acid which encodes a protein wherein at least one optimal or non-optimal codon in a wild type nucleic acid encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: February 1, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jeffery M. Coller, Kristian E. Baker