Patents Assigned to Case Western Reserved University
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Patent number: 12376837Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.Type: GrantFiled: December 8, 2021Date of Patent: August 5, 2025Assignee: Case Western Reserve UniversityInventors: Sanford Markowitz, Amitabh Chak, Joseph Willis, Jeffrey Silver Taggart, Rebecca Blice, Dean Secrest, Dennis Siedlak
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Patent number: 12336982Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.Type: GrantFiled: November 21, 2019Date of Patent: June 24, 2025Assignees: Rodeo Therapeutics Corporation, Case Western Reserve University, Board of Regents of the University of Texas SystemInventors: Sanford Markowitz, Joseph Ready, Stephen L. Gwaltney, II, Monika Antczak
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Publication number: 20250195050Abstract: A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.Type: ApplicationFiled: February 27, 2025Publication date: June 19, 2025Applicant: Case Western Reserve UniversityInventors: Amitabh Chak, Sanford Markowitz, Dennis Siedlak, Joseph Willis, Lishan Aklog, Michael Boutillette, Richard Yazbeck
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Patent number: 12319804Abstract: A High Internal Phase Emulsion (HIPE) foam having cellulose nanoparticles.Type: GrantFiled: October 6, 2023Date of Patent: June 3, 2025Assignees: The Procter & Gamble Company, Case Western Reserve UniversityInventors: Stuart J. Rowan, Donald L. Feke, Vahid Karimkhani, Ica Manas-Zloczower, Boran Zhao, Wade Monroe Hubbard, Jr., Maxwell Joseph Wingert, Steven Ray Merrigan
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Patent number: 12312390Abstract: A two-chain insulin analogue contains a modified A-chain polypeptide and a modified B-chain polypeptide. The A-chain polypeptide comprises one or more of: a His or Glu substitution at position A8, a Glu substitution at position A14; and a Gln or Arg substitution at position A17. The B-chain polypeptide comprises one or more of: a deletion of the amino acids at position B1, B1-B2, B1-B3, B30 or a combination thereof; an Ala or Glu substitution at position B2; a Glu substitution at position B3. The analogue exhibits thermodynamic stability in a zinc-free solution, decreased self-association, maintains biological potency, and no increased mitogenicity. The analogue exhibits resistance to chemical degradation and physical degradation. A method of treating a patient with diabetes mellitus or obesity comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient.Type: GrantFiled: December 27, 2021Date of Patent: May 27, 2025Assignee: Case Western Reserve UniversityInventor: Michael A. Weiss
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Patent number: 12310954Abstract: A method is provided for promoting salivary gland regeneration in a subject in need thereof comprising administering to acinar progenitor cells of the salivary gland at least one of a cholinergic agonist or muscarinic agonist to promote acinar cell generation. In particular, formulations comprising a muscarinic agonist such as cevimeline encapsulated in an alginate hydrogel can be formulated for local administration to a salivary gland and used in treatment of xerostomia.Type: GrantFiled: December 10, 2019Date of Patent: May 27, 2025Assignees: Case Western Reserve University, The Regents of the University of CaliforniaInventors: Sarah Knox, Chelsea S. Bahney, Eben Alsberg, Oju Jeon
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Patent number: 12281260Abstract: Wellbore treatment fluids are provided that include an aqueous component and an amphiphilic hyperbranched copolymer comprising the polymerized reaction product of at least a first monomer and a second monomer, where the first monomer comprises at least one surface reactive end group chosen from the group consisting of carboxylates, phosphonates, sulfonates, and zwitterions. Also provided are methods of modifying subsurface energy of a carbonate formation using the wellbore treatment fluids.Type: GrantFiled: June 23, 2023Date of Patent: April 22, 2025Assignees: Saudi Arabian Oil Company, Case Western Reserve UniversityInventors: Feng Liang, Hui-Hai Liu, Jin Ge, Jose I. Rueda, Mohammed A. Bataweel
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Patent number: 12262879Abstract: A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.Type: GrantFiled: June 16, 2020Date of Patent: April 1, 2025Assignee: Case Western Reserve UniversityInventors: Amitabh Chak, Sanford Markowitz, Dennis Siedlak, Joseph Willis, Lishan Aklog, Michael Boutillette, Richard Yazbeck
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Patent number: 12260842Abstract: Systems, methods, and media for displaying interactive augmented reality presentations are provided. In some embodiments, a system comprises: a head mounted display comprising: a transparent display; a plurality of sensors; and at least one processor, wherein the at least one processor is programmed to: select a content display location of a plurality of predetermined content display locations to use to present content based at least in part on a location of the head mounted display within a current physical environment; and cause content to be presented by the head mounted display anchored at the selected content display location.Type: GrantFiled: May 7, 2024Date of Patent: March 25, 2025Assignee: Case Western Reserve UniversityInventors: Mark A. Griswold, Henry Eastman, Robert Gotschall
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Patent number: 12253587Abstract: The present disclosure provides transmit/receive (T/R) systems for NMR or MRI systems. In one configuration, the systems and methods provided herein may use passively-shielded coils that are compatible with low-field operational environment to replace conventional T/R systems and spatial gradient systems. In some configurations, a low-field imaging T/R system is provided that is designed for nuclear magnetic stimulation and local flux sensitivity, while automatically rejecting incident radiant electromagnetic noise. The design advantageously leverages low required frequencies to distribute the pulse synthesis task, yielding a smaller system with easier maintenance and lower cost. The system may include distributed coil nodes that include a primary radiofrequency (RF) coil configured to transmit and receive RF signals and a secondary coil configured to passively shield the primary RF coil.Type: GrantFiled: March 10, 2023Date of Patent: March 18, 2025Assignee: Case Western Reserve UniversityInventors: Nicholas Reid Bolding, Mark A. Griswold
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Patent number: 12227810Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.Type: GrantFiled: February 1, 2024Date of Patent: February 18, 2025Assignee: Case Western Reserve UniversityInventors: Sanford D. Markowitz, Helen Moinova, Amitabh Chak, Joseph Willis, Thomas LaFramboise
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Patent number: 12230397Abstract: Embodiments discussed herein facilitate determining a prognosis for keratoplasty based on segmented endothelial cells. One example embodiment comprises a computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, comprising: accessing an optical microscopy image comprising a set of corneal endothelial cells of a patient of a keratoplasty; segmenting, based at least in part on a first model, a plurality of corneal endothelial cells of the set of corneal endothelial cells; calculating one or more features based on the segmented plurality of corneal endothelial cells; and generating, via a second model trained based at least on the one or more features, a prognosis associated with the keratoplasty.Type: GrantFiled: June 22, 2020Date of Patent: February 18, 2025Assignee: Case Western Reserve UniversityInventors: David L. Wilson, Hao Wu, Naomi Joseph, Chaitanya Kolluru, Beth Benetz, Jonathan Lass
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Patent number: 12201579Abstract: As an example, a walker includes a first leg pair, a second leg pair and a cross beam connecting the first and second leg pairs in a parallel, spaced apart relationship. Each leg pair includes a U-shaped tube defining a front leg and a rear leg. A front strut is telescopically movable within the front leg and extends outwardly therefrom. A rear strut is telescopically movable within the rear leg and extends outwardly therefrom. A mechanical linear actuator includes a rotating element adapted to rotate relative to at least one of the front leg or the rear leg. The rotating element includes an interface with a track on the respective strut relative to which the rotating element rotates, whereby rotational motion of the rotating element translates to corresponding linear motion of the strut.Type: GrantFiled: June 7, 2023Date of Patent: January 21, 2025Assignees: The United States Government As Represented By The Department Of Veterans Affairs, Case Western Reserve UniversityInventors: Ronald J. Triolo, Marc Louis Vitantonio, Robert Craig Allen, Shawn William Dellinger, Anna E. Krakora
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Publication number: 20240425747Abstract: Wellbore treatment fluids are provided that include an aqueous component and an amphiphilic hyperbranched copolymer comprising the polymerized reaction product of at least a first monomer and a second monomer, where the first monomer comprises at least one surface reactive end group chosen from the group consisting of carboxylates, phosphonates, sulfonates, and zwitterions. Also provided are methods of modifying subsurface energy of a carbonate formation using the wellbore treatment fluids.Type: ApplicationFiled: June 23, 2023Publication date: December 26, 2024Applicants: Saudi Arabian Oil Company, Case Western Reserve UniversityInventors: Feng Liang, Hui-Hai Liu, Jin Ge, Jose I. Rueda, Mohammed A. Bataweel
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Patent number: 12102644Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of 8,9-unsaturated sterols in the OPCs, the agent comprising a compound having the formula (I): wherein variables Y1, R1 and R2 are as defined herein.Type: GrantFiled: April 17, 2019Date of Patent: October 1, 2024Assignee: Case Western Reserve UniversityInventors: Drew Adams, Dharmaraja Allimuthu, Zita Hubler
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Patent number: 12103331Abstract: A transformable wheel assembly includes a spoke frame and a central gear coupled to the spoke frame. A plurality of legs are pivotably coupled to the spoke frame. The plurality of legs include an arcuate outer surface and an arcuate distal interior edge. A plurality of leg teeth are formed on the arcuate distal interior edge. The leg teeth engage the central gear such that the central gear drives the plurality of legs between a closed position and an open position based on a direction of rotation of the central gear.Type: GrantFiled: April 19, 2021Date of Patent: October 1, 2024Assignee: Case Western Reserve UniversityInventor: Kiju Lee
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Patent number: 12083342Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.Type: GrantFiled: August 8, 2022Date of Patent: September 10, 2024Assignees: Galvani Bioelectronics Limited, Case Western Reserve UniversityInventors: Alessandra Giarola, Yee-Hsee Hsieh, Stephen J. Lewis, Arun Sridhar
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Patent number: 12060577Abstract: The present disclosure relates to methods for expanding and increasing the cytotoxic activity of natural killer cells comprising co-culturing, as feeder cells, a population of myeloid leukemia cells engineered to express one or more of membrane-bound IL-21 (mb IL-21) or membrane-bound IL-15 (mbIL-15) in the presence of cytokine support. The present disclosure also relates to a population of acute myeloid leukemia cells engineered to express one or more of membrane-bound IL-21 (mbIL-21) or membrane-bound IL-15 (mbIL-15). The present disclosure also relates to methods of treating cancer employing the step of expanding natural killer cells using feeder cells engineered to express one or more of membrane-bound IL-21 (mbIL-21) or membrane-bound IL-15 (mbIL-15).Type: GrantFiled: May 21, 2018Date of Patent: August 13, 2024Assignee: Case Western Reserve UniversityInventor: David N. Wald
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Patent number: RE50286Abstract: Embodiments classify lung nodules by accessing a 3D radiological image of a region of tissue, the 3D image including a plurality of voxels and slices, a slice having a thickness; segmenting the nodule represented in the 3D image across contiguous slices, the nodule having a 3D volume and 3D interface, where the 3D interface includes an interface voxel; partitioning the 3D interface into a plurality of nested shells, a nested shell including a plurality of 2D slices, a 2D slice including a boundary pixel; extracting a set of intra-perinodular textural transition (Ipris) features from the 2D slices based on a normal of a boundary pixel of the 2D slices; providing the Ipris features to a machine learning classifier which computes a probability that the nodule is malignant, based, at least in part, on the set of Ipris features; and generating a classification of the nodule based on the probability.Type: GrantFiled: June 22, 2022Date of Patent: January 28, 2025Assignee: Case Western Reserve UniversityInventors: Anant Madabhushi, Mehdi Alilou
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Patent number: RE50416Abstract: Embodiments include accessing a set of digital pathology (DP) images having an imaging parameter; applying a low-computational cost histology quality control (HistoQC) pipeline to the DP images, where the low-computational cost HistoQC pipeline computes a first set of image metrics associated with a DP image, and assigns the DP image to a first or a second, different cohort based on the imaging parameter and the first set of image metrics; applying a first, higher-computational-cost HistoQC pipeline to a member of the first cohort; applying a second, different higher-computation-cost HistoQC pipeline to a member of the second cohort; where the first or second, higher-computational-cost HistoQC pipeline determines an artifact-free region of the member of the first or second cohort, respectively, and classifies the member of the first or second cohort, respectively, as suitable or unsuitable for downstream computation or diagnostic analysis based, at least in part, on the artifact free region.Type: GrantFiled: December 7, 2022Date of Patent: May 6, 2025Assignee: Case Western Reserve UniversityInventors: Anant Madabhushi, Andrew Janowczyk