Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.
Type:
Application
Filed:
April 21, 2017
Publication date:
November 9, 2017
Applicants:
CATALENT PHARMA SOLUTIONS INC., UNIVERSITY OF MISSISSIPPI
Inventors:
Sampada Bhaskar UPADHYE, Ronald S. VLADYKA, R.ph, Michael Andrew REPKA, Jun-Bom PARK, Roshan Vijay TIWARI, Hemlata Gunga PATIL, Joseph Thomas MOROTT, JR., Wenli LU
Abstract: The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.
Type:
Grant
Filed:
March 9, 2010
Date of Patent:
January 10, 2017
Assignee:
CATALENT PHARMA SOLUTIONS, INC.
Inventors:
Gregory T. Bleck, Dona York, Ian Collins
Abstract: The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.
Type:
Application
Filed:
March 9, 2010
Publication date:
September 9, 2010
Applicant:
CATALENT PHARMA SOLUTIONS, INC.
Inventors:
Gregory T. Bleck, Dona York, Ian Collins
Abstract: The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.
Type:
Grant
Filed:
July 28, 2004
Date of Patent:
April 13, 2010
Assignee:
Catalent Pharma Solutions, Inc.
Inventors:
Gregory T. Bleck, Dona York, Ian Collins