Abstract: A homogeneous catalytic reaction method and a catalyst for isomerization and hydroformylation of long-chain internal olefins are disclosed. A rhodium-ruthenium metal complex is used as a catalyst; and the ligands are tetradentate phosphine ligands. By means of the catalytic system, homogeneous internal olefin isomerization aid hydroformylation can be performed under a certain temperature and pressure to obtain aldehyde products having high normal to iso ratios. The present invention is applicable to not only long-chain internal olefins (?C8) but also internal olefins having a carbon number less than 8.
Abstract: An electronic system and a method for efficiently documenting medical findings that consist of both a problem and a location on or in the body. This invention further provides a method for documenting multiple problems in related body locations. This invention further provides a method for efficiently issuing orders associated with medical findings that consist of both a problem and a location on or in the body. The invention is able to enhance efficiency during the Physical exam making the invention an essential component of the physician's practice workflow. This, in turn, will enable the invention to serve as a single point of integration for a vast array of useful electronic tools and information.
Type:
Grant
Filed:
November 23, 2001
Date of Patent:
April 29, 2014
Assignee:
Catalis, Inc.
Inventors:
Michael D. Dahlin, Randolph B Lipscher, Eric Wohl
Abstract: A method of formulating a medical order for a patient includes transmitting a medical order interface to a healthcare provider interface device. The medical order interface includes a plurality of selectable medical order items. The method further includes, in response to receiving a selection of a medical order item of the plurality of selectable medical order items, transmitting an authorization request interface to the healthcare provider interface device. The authorization request interface includes a set of selectable findings controls. Each selectable findings control of the set of selectable findings controls is associated with a set of medical findings associated with the patient. The authorization request interface includes a send control. In addition, the method includes, in response to receiving a selection of a select findings control and receiving selection of the send control, sending an electronic authorization request.
Type:
Grant
Filed:
September 19, 2007
Date of Patent:
October 30, 2012
Assignee:
Catalis, Inc.
Inventors:
Randolph B. Lipscher, Eric Wohl, Michael D. Dahlin
Abstract: The present invention relates to the preparation of compounds of formula (I) derived from arylacetic acid comprising two phenol functions and an amide function, which have free-radical scavenging and antioxidant properties and which are soluble in lipid media. These compounds can be used as cosmetic and pharmaceutical preparations for the prevention of biological degradations caused by free radicals.
Abstract: The present invention relates to the preparation of compounds of formula (I) derived from arylacetic acid comprising two phenol functions and an amide function, which have free-radical scavenging and antioxidant properties and which are soluble in lipid media. These compounds can be used as cosmetic and pharmaceutical preparations for the prevention of biological degradations caused by free radicals.
Abstract: A computer-implemented method for adaptively supporting medical decisions of at least one user includes receiving a first input from a first device, receiving a second input from a second device, determining a suggested medical decision based at least in part on the first input and the second input, and transferring the suggested medical decision to the second device.
Type:
Application
Filed:
October 14, 2005
Publication date:
May 25, 2006
Applicant:
Catalis, Inc.
Inventors:
Risto Miikkulainen, Michael Dahlin, Randolph Lipscher
Abstract: The invention relates to a process for preparing cis-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, or racemic sertraline, corresponding to formula (I)
in salt form, starting with 4-(3,4-dichlorophenyl)tetralone of formula (II)
according to which (a) the 4-(3,4-dichlorophenyl)tetralone of formula (II) is reacted with N-methylformamide in the presence of formic acid, (b) the reaction medium obtained according to (a) is treated with a base, and (c) the racemic sertraline salt is separated out by selective crystallization with an acid. The invention also relates to N-methylformamide-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine and to its use to obtain racemic sertraline.