Patents Assigned to Catalyst Biosciences, Inc.
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Patent number: 11491212Abstract: Methods for prophylactic treatment of hemophilia B are provided in which modified FIX polypeptides, particularly FIXa, are subcutaneously administered daily or less frequently, such as every other day, or every 2, 3 or 4 days. The treatment results in normal coagulation pharmacokinetics and normal levels of FIX, or mild hemophilia B.Type: GrantFiled: September 27, 2018Date of Patent: November 8, 2022Assignee: Catalyst Biosciences, Inc.Inventor: Howard Levy
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Patent number: 11401513Abstract: Provided are MTSP-1 polypeptides modified to have altered activity and/or specificity so that they cleave a complement protein, such as complement protein C3, to inhibit its activity and thereby inhibit complement activation. The modified MTSP-1 polypeptides that inhibit complement activation can be used for treatment of diseases and conditions in which complement activation plays a role. Such diseases and conditions include inflammatory diseases and diseases with an inflammatory component. Exemplary of these disorders are ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, ophthalmic disorders, such as diabetic retinopathies and macular degeneration, including age-related macular degeneration (AMD), and transplanted organ rejection, such as renal delayed graft function (DGF).Type: GrantFiled: October 8, 2020Date of Patent: August 2, 2022Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Vanessa Soros, Mikhail Popkov
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Patent number: 11266724Abstract: Provided herein are modified FVII polypetides, and modified FVIIa polypeptides, and methods of treatment of acute and episodic bleeding with modified FactorVIIa polypeptides. To effect treatment and use, in some embodiments, the modified polypeptides are subcutaneously administered to provide on-demand treatment. In some embodiments, the on-demand treatment is provided in a multiple dosing regimen over a twenty-four hour period. The subcutaneous administration of the modified polypeptides of the disclosure exhibit increased coagulant activity, potency, bioavailablilty and prolonged duration.Type: GrantFiled: February 19, 2021Date of Patent: March 8, 2022Assignee: CATALYST BIOSCIENCES, INC.Inventors: Grant E. Blouse, Tom Knudsen, Howard Levy
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Patent number: 11203749Abstract: Nucleic acids encoding modified factor VII polypeptides, vectors and cells containing the nucleic acids, uses of the nucleic acids, methods of making the encoded polypeptides, and methods of treatment are provided. The encoded modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among the encoded modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities.Type: GrantFiled: November 2, 2018Date of Patent: December 21, 2021Assignee: CATALYST BIOSCIENCES, INC.Inventors: Edwin L. Madison, Christopher Thanos
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Patent number: 10982203Abstract: Nucleic acid molecules encoding modified factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.Type: GrantFiled: March 29, 2016Date of Patent: April 20, 2021Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Christopher Thanos, Grant Ellsworth Blouse
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Patent number: 10954501Abstract: Provided are MTSP-1 polypeptides modified to have altered activity and/or specificity so that they cleave a complement protein, such as complement protein C3, to inhibit its activity and thereby inhibit complement activation. The modified MTSP-1 polypeptides that inhibit complement activation can be used for treatment of diseases and conditions in which complement activation plays a role. Such diseases and conditions include inflammatory diseases and diseases with an inflammatory component. Exemplary of these disorders are ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, ophthalmic disorders, such as diabetic retinopathies and macular degeneration, including age-related macular degeneration (AMD), and transplanted organ rejection, such as renal delayed graft function (DGF).Type: GrantFiled: June 2, 2020Date of Patent: March 23, 2021Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Vanessa Soros, Mikhail Popkov
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Patent number: 10781435Abstract: Provided are MTSP-1 polypeptides modified to have altered activity and/or specificity so that they cleave a complement protein, such as complement protein C3, to inhibit its activity and thereby inhibit complement activation. The modified MTSP-1 polypeptides that inhibit complement activation can be used for treatment of diseases and conditions in which complement activation plays a role. Such diseases and conditions include inflammatory diseases and diseases with an inflammatory component. Exemplary of these disorders are ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, ophthalmic disorders, such as diabetic retinopathies and macular degeneration, including age-related macular degeneration (AMD), and transplanted organ rejection, such as renal delayed graft function (DGF).Type: GrantFiled: June 21, 2018Date of Patent: September 22, 2020Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Vanessa Soros, Mikhail Popkov
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Patent number: 10716770Abstract: The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for use, and their pharmaceutical compositions.Type: GrantFiled: April 15, 2019Date of Patent: July 21, 2020Assignee: Catalyst Biosciences, Inc.Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Ronald Joseph Heemstra, Jason Speake, Daniel Yohannes, Matt S. Melvin, Yunde Xiao
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Patent number: 10258582Abstract: The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.Type: GrantFiled: January 23, 2018Date of Patent: April 16, 2019Assignee: Catalyst BioSciences, Inc.Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Ronald Joseph Heemstra, Jason Speake, Daniel Yohannes, Matt S. Melvin, Yunde Xiao
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Patent number: 10160961Abstract: Nucleic acid encoding modified factor VII polypeptides, vectors and cells containing the nucleic acid, uses of the nucleic acids, methods of making the encoded polypeptides, and methods of treatment are provided. The encoded modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among the encoded modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities.Type: GrantFiled: September 7, 2016Date of Patent: December 25, 2018Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Christopher Thanos
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Patent number: 9856467Abstract: Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided.Type: GrantFiled: April 3, 2014Date of Patent: January 2, 2018Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Christopher Thanos
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Patent number: 9795655Abstract: Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders.Type: GrantFiled: May 12, 2014Date of Patent: October 24, 2017Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Jack Nguyen, Sandra Waugh Ruggles, Christopher Thanos
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Patent number: 9476037Abstract: Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.Type: GrantFiled: July 30, 2013Date of Patent: October 25, 2016Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Christopher Thanos
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Patent number: 9359598Abstract: MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.Type: GrantFiled: May 20, 2013Date of Patent: June 7, 2016Assignee: Catalyst Biosciences, Inc.Inventors: Sandra Waugh Ruggles, Jack Nguyen
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Patent number: 9328339Abstract: Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.Type: GrantFiled: May 1, 2014Date of Patent: May 3, 2016Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Christopher Thanos, Grant Ellsworth Blouse
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Patent number: 9290757Abstract: Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.Type: GrantFiled: May 18, 2012Date of Patent: March 22, 2016Assignee: Catalyst Biosciences, Inc.Inventor: Edwin L. Madison
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Patent number: 9145552Abstract: Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided.Type: GrantFiled: March 15, 2013Date of Patent: September 29, 2015Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Christopher Thanos
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Publication number: 20140242062Abstract: Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders.Type: ApplicationFiled: May 12, 2014Publication date: August 28, 2014Applicant: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Jack Nguyen, Sandra Waugh Ruggles, Christopher Thanos
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Patent number: 8778870Abstract: Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.Type: GrantFiled: November 3, 2011Date of Patent: July 15, 2014Assignee: Catalyst Biosciences, Inc.Inventors: Edwin L. Madison, Christopher Thanos, Grant Ellsworth Blouse
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Patent number: 8663633Abstract: Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.Type: GrantFiled: July 2, 2012Date of Patent: March 4, 2014Assignees: Torrey Pines Institute for Molecular Studies, Catalyst Biosciences, Inc.Inventor: Edwin L. Madison