Patents Assigned to Catholic University Industry Academic Cooperation Foundation
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Publication number: 20250072917Abstract: A system for removing a thrombus in a blood vessel, includes: a main body part which is movable along the blood vessel and performs a revascularization function within the blood vessel during installation, and sucks and transfers the thrombus during aspiration; a microflow circuit part which is attached to the outer surface of the main body part and extends to the exterior of the body, creates a microflow circuit which acts on the thrombus to move, deform, and fragment the thrombus; and an aspiration part which is provided to the exterior of the body from the inside of the blood vessel, and which during aspiration, after blocking blood flow in the blood vessel, aspirates the thrombus which has been moved, deformed and fragmented by the microflow circuit part and transferred by the main body part and discharges the thrombus to the outside of the body.Type: ApplicationFiled: August 18, 2023Publication date: March 6, 2025Applicant: DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventor: Sung Won YOUN
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Publication number: 20240189482Abstract: Provided are a method for fabricating a human nasal turbinate-derived mesenchymal stem cell-based 3D bioprinted construct, and a use thereof, wherein the human nasal turbinate-derived mesenchymal stem cell-based, 3D bioprinted construct is advantageous over conventional mesenchymal stem cell-based, 3D bioprinted constructs in that the former can survive and proliferate stably in vitro and/or in vivo and shows high osteogenic differentiation ability as well, therefore is expected to make a great contribution to the practical use of cellular therapeutic agents.Type: ApplicationFiled: February 21, 2024Publication date: June 13, 2024Applicant: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Sung Won KIM, Jung Yeon LIM, Sun Hwa PARK, Byeong Gon YOON, Dong-Woo CHO, Jinah JANG, Seok Won KIM
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Publication number: 20240165127Abstract: There is provided a contrast agent for diagnosis of vascular disease containing a gadolinium-based compound as an active ingredient. It has been found that the gadolinium-based compound Gd-DOTA-click-SF of the present disclosure, has a higher molar longitudinal relaxivity (r1) than Dotarem, is stable, and does not affect in vitro cell viability. In addition, it has been found through MRI images that the specific binding of Gd-DOTA-click-SF in an animal model of abdominal aortic aneurysm established using elastase, a serine protease, is remarkable. Also, it has been confirmed that the content of the gadolinium-based compound of the present disclosure that binds to serine protease in the aorta, that is, the content of gadolinium in the aorta, is remarkable. Thus, the Gd-DOTA-click-SF compound according to the present disclosure may be usefully used in MRI and CT imaging diagnosis for vascular disease.Type: ApplicationFiled: October 27, 2023Publication date: May 23, 2024Applicant: DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Sung Won YOUN, Phuong Tu HUYNH, Huy Duc VU, Jung-hwa RYU
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Patent number: 11987496Abstract: A method for producing a bis(fluorosulfonyl)imide lithium salt is disclosed. The method includes the steps of: (a) reacting bis(chlorosulfonyl)imide with NH4F(HF)n (n=0-10) to prepare ammonium bis(fluorosulfonyl)imide; and (b) reacting the ammonium bis(fluorosulfonyl)imide with a lithium base, wherein in at least one of steps (a) and (b), after the reaction, a process of adding an alkoxy trialkyl silane to the reaction solution to remove a fluorine anion is performed.Type: GrantFiled: September 4, 2019Date of Patent: May 21, 2024Assignee: DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Sang Ryul Lee, Kyoung Chol Kim, Ja Young Park, Ji Hyeong Kim, Jeong In Kim, Seok Ju Lee, Jongyun Jang, Seongjeong Lee, Mingi Chu, Dong Wook Kang
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Patent number: 11938247Abstract: Provided are a method for fabricating a human nasal turbinate-derived mesenchymal stem cell-based 3D bioprinted construct, and a use thereof, wherein the human nasal turbinate-derived mesenchymal stem cell-based, 3D bioprinted construct is advantageous over conventional mesenchymal stem cell-based, 3D bioprinted constructs in that the former can survive and proliferate stably in vitro and/or in vivo and shows high osteogenic differentiation ability as well, therefore is expected to make a great contribution to the practical use of cellular therapeutic agents.Type: GrantFiled: May 2, 2018Date of Patent: March 26, 2024Assignee: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Sung Won Kim, Jung Yeon Lim, Sun Hwa Park, Byeong Gon Yoon, Dong-Woo Cho, Jinah Jang, Seok Won Kim
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Patent number: 11612620Abstract: The present invention relates to a pharmaceutical composition for preventing or treating rheumatoid arthritis, and a stem cell therapeutic agent for treating rheumatoid arthritis, comprising nasal inferior turbinate-derived mesenchymal stem cells as an active ingredient. Nasal inferior turbinate-derived mesenchymal stem cells of the present invention have the effects of reducing the production of interleukin-17A (IL-17A), tumor necrosis factor-? (TNF-?), immunoglobulin G2 (IgG2a) which is an inflammation-inducing factor, and/or the proliferative ability of lymph node T cells, increasing interleukin-10 (IL-10) and/or regulatory T-cells (Treg, CD4+CD25+foxp3+ cell) that contribute to immune tolerance in spleen cells, and inhibiting the proliferation of human T-cells.Type: GrantFiled: June 21, 2018Date of Patent: March 28, 2023Assignee: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Sung Won Kim, Seung Ki Kwok, Jaeseon Lee, Sun hwa Park, Jung Yeon Lim
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Patent number: 11591305Abstract: The present invention provides a method for producing fisetin or fisetin derivatives, which is capable of mass production. The method for producing fisetin or fisetin derivatives according to the present invention is capable of mass-producing fisetin or fisetin derivatives without a purification process such as a column chromatography process.Type: GrantFiled: January 7, 2022Date of Patent: February 28, 2023Assignee: DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Dong Wook Kang, Min Gi Chu, Seok Ju Lee, Eun Jung Lee
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Publication number: 20210347639Abstract: A method for producing a bis(fluorosulfonyl)imide lithium salt is disclosed. The method includes the steps of: (a) reacting bis(chlorosulfonyl)imide with NH4F(HF)n (n=0-10) to prepare ammonium bis(fluorosulfonyl)imide; and (b) reacting the ammonium bis(fluorosulfonyl)imide with a lithium base, wherein in at least one of steps (a) and (b), after the reaction, a process of adding an alkoxy trialkyl silane to the reaction solution to remove a fluorine anion is performed.Type: ApplicationFiled: September 4, 2019Publication date: November 11, 2021Applicant: DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Sang Ryul LEE, Kyoung Chol KIM, Ja Young PARK, Ji Hyeong KIM, Jeong In KIM, Seok Ju LEE, Jongyun JANG, Seongjeong LEE, Mingi CHU, Dong Wook KANG
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Publication number: 20210315957Abstract: A pharmaceutical composition and a health functional food composition for preventing, treating, or improving muscular diseases have licorice extract or a fraction thereof, or a compound isolated therefrom or a pharmaceutically acceptable salt thereof, as an active ingredient. The licorice extract or a fraction thereof, the compound or salt thereof induce the myoblasts proliferation and promote the differentiation into myotubes, and since the licorice extract or a fraction thereof, the compound or salt thereof has an excellent effect on regenerating damaged muscles, various muscle diseases are effectively prevented, improved or treated using the composition.Type: ApplicationFiled: June 17, 2020Publication date: October 14, 2021Applicants: RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY, KOREA INSTITUTE OF ORIENTAL MEDICINE, DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Inho CHOI, Eun Ju LEE, So-young PARK, Yong-Ho LEE, Jin Yeul MA, Won-Kyung CHO, Hye Jin YANG
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Patent number: 11123402Abstract: An anticancer composition includes cervical cancer-derived autocrine motility factor (AMF) as an effective component. The cervical cancer-derived AMF has an excellent effect of inhibiting the proliferation of liver cancer, pancreatic cancer, breast cancer, lung cancer, prostate cancer, and colon cancer, and inducing cell death. The composition can be used as an anticancer therapeutic agent.Type: GrantFiled: June 4, 2018Date of Patent: September 21, 2021Assignee: DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventor: Hee Sung Park
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Patent number: 10894945Abstract: Provided are methods for improving the proliferation and stemness of limbal stem cells (LSCs) by adding a Wnt inhibitor to a medium for limbal explant cultures. When human limbal explants are cultured according to the methods, Wnt/?-catenin signaling is inhibited, resulting in improvement of LSC proliferation, and improvement in the stemness of LSCs, and thus the LSCs may be obtained in high yield.Type: GrantFiled: March 20, 2017Date of Patent: January 19, 2021Assignee: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: So-Hyang Chung, Hyun Jung Lee
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Patent number: 10792309Abstract: The present invention relates to a cell therapy composition for preventing or treating immune disease comprising mesenchymal stem cells and immunoregulatory T-cells as an active ingredient. By infusing mesenchymal stem cells and immunoregulatory T-cells, which are the cellular therapeutic agent of the present invention, into bone marrow transplant animals, rejection to the host is suppressed after the engraftment of the transplanted bone-marrow to thus obtain the effect of reducing graft-versus-host disease and immune disease. Moreover, the effect of such GVHD reduction is much greater than the one obtained when only mesenchymal stem cells are infused. Accordingly, the cell therapy composition of the present invention having the above-mentioned effects can be useful in the prevention or treatment of immune disease.Type: GrantFiled: August 13, 2013Date of Patent: October 6, 2020Assignee: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Mi La Cho, Seok-Goo Cho, Jung-Yeon Lim, Hyun-Sil Park, Min-Jung Park
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Publication number: 20200197570Abstract: Provided are a method for fabricating a human nasal turbinate-derived mesenchymal stem cell-based 3D bioprinted construct, and a use thereof, wherein the human nasal turbinate-derived mesenchymal stem cell-based, 3D bioprinted construct is advantageous over conventional mesenchymal stem cell-based, 3D bioprinted constructs in that the former can survive and proliferate stably in vitro and/or in vivo and shows high osteogenic differentiation ability as well, therefore is expected to make a great contribution to the practical use of cellular therapeutic agents.Type: ApplicationFiled: May 2, 2018Publication date: June 25, 2020Applicant: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Sung Won KIM, Jung Yeon LIM, Sun Hwa PARK, Byeong Gon YOON, Dong-Woo CHO, Jinah JANG, Seok Won KIM
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Patent number: 10602956Abstract: The present invention relates to a radiation amount estimating method, and more particularly, to a radiation amount estimating method of an MRI based composite image using a lookup table. To this end, the object of the present invention is to provide a radiation dose estimating method of an MRI based composite image using a lookup table including: generating a lookup table representing a linear attenuation coefficient of a region of interest from a CT image (S100); photographing at least two of a T1 image, a T2 image, and a PETRA image of a patient from MRI equipment (S120); generating a composite image by superimposing the photographed images (S140); representing a border line of the region of interest in the composite image to distinguish the region of interest (S160); designating the linear attenuation coefficient of the lookup table in the distinguished region of interest (S180); and estimating a radiation dose based on the composite image to which the linear attenuation coefficient is designated (S200).Type: GrantFiled: March 23, 2017Date of Patent: March 31, 2020Assignee: Catholic University Industry-Academic Cooperation FoundationInventors: Young-Nam Kang, Shin-Wook Kim, Jina Kim, Hun-joo Shin, Hyeong-Wook Park, Chul-Seung Kay, Ki-jun Kim, Jin-Sol Shin
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Patent number: 10550432Abstract: The present invention relates to a method of predicting the risk of developing ankylosing spondylitis using DNA copy number variation. It was verified that the risk of developing ankylosing spondylitis can be effectively predicted using primers for detecting DNA copy number variation, of the present invention, and the sensitivity and specificity of prediction can be improved by grafting the results of single nucleotide polymorphism (SNP) measurements, and thus more fundamental approaches for preventing and treating ankylosing spondylitis are expected.Type: GrantFiled: September 30, 2014Date of Patent: February 4, 2020Assignee: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Yeun-Jun Chung, Tae-Hwan Kim, Seung Cheol Shim, Seung-Hyun Jung
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Publication number: 20190269346Abstract: The present invention relates to a radiation amount estimating method, and more particularly, to a radiation amount estimating method of an MRI based composite image using a lookup table. To this end, the object of the present invention is to provide a radiation dose estimating method of an MRI based composite image using a lookup table including: generating a lookup table representing a linear attenuation coefficient of a region of interest from a CT image (S100); photographing at least two of a T1 image, a T2 image, and a PETRA image of a patient from MRI equipment (S120); generating a composite image by superimposing the photographed images (S140); representing a border line of the region of interest in the composite image to distinguish the region of interest (S160); designating the linear attenuation coefficient of the lookup table in the distinguished region of interest (S180); and estimating a radiation dose based on the composite image to which the linear attenuation coefficient is designated (S200).Type: ApplicationFiled: March 23, 2017Publication date: September 5, 2019Applicant: CATHOLIC UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Young-Nam Kang, Shin-Wook Kim, Jina Kim, Hun-joo Shin, Hyeong-Wook Park, Chul-Seung Kay, Ki-jun Kim, Jin-Sol Shin
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Patent number: 10279046Abstract: The present invention relates to a composition for treating an ocular inflammatory disease, comprising hydrophilic sulfasalazine and hyaluronic acid, and a preparation method therefor. Furthermore, the present invention relates to a method for treating an ocular inflammatory disease, which comprises administering, to an individual, a therapeutically effective amount of hydrophilic sulfasalazine and hyaluronic acid.Type: GrantFiled: March 6, 2014Date of Patent: May 7, 2019Assignee: CATHOLIC UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Choun-Ki Joo, Jun-Sub Choi
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Patent number: 10258662Abstract: Provided is a method for preventing or treating hepatitis C by administrating a composition including, as an active ingredient, a Vitidis Vinferae Radix extract or a fraction thereof and, more specifically, to a Vitidis Vinferae Radix extract which is extracted with water and alcohol or a mixed solvent thereof, or a fraction thereof, which have remarkably low hepatotoxicity and exhibit an excellent effect of selectively inhibiting genome replication of a hepatitis C virus, and thus can be useful for preventing or treating hepatitis C.Type: GrantFiled: April 29, 2014Date of Patent: April 16, 2019Assignees: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Choongho Lee, Tae Hwe Heo, Kee Dong Yoon
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Patent number: 10172596Abstract: The present invention relates to a biological tissue biopsy device including a body extending in a longitudinal direction, an outer needle installed to be connected to one side of the body and be extended in a longitudinal direction and including a first tube having a hollow portion formed therein and a second tube disposed in a direction parallel to the first tube to guide a hemostatic substance, an inner needle provided inside the first tube and extending in a longitudinal direction, and a sliding means provided in the body and installed to be connected to one end of the inner needle so as to enable the inner needle to move forward and backward. Here, the sliding means causes the inner needle to move a predetermined distance from the hollow portion of the first tube and be inserted into a target site.Type: GrantFiled: January 3, 2014Date of Patent: January 8, 2019Assignees: Dongguk University Industry-Academic Cooperation Foundation, Catholic University Industry Academic Cooperation FoundationInventors: Sung Min Kim, In Chul Yang, In Sung Moon, Ji Il Kim, Sun Cheol Park, Jeong Kye Hwang
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Patent number: 10130802Abstract: A capsule endoscope for photodynamic and sonodynamic therapy is disclosed. The capsule includes: an endoscope body; a light and ultrasonic wave irradiation portion provided on the outer surface of the endoscope body and irradiating light of different wavelengths and ultrasonic waves; and a photodynamic and sonodynamic therapy portion connected to the outer surface of the endoscope body and comprising a material for photodynamic and sonodynamic therapy, wherein the photodynamic and sonodynamic therapy portion can be activated by the light and ultrasonic waves irradiated from the light and ultrasonic wave irradiation portion.Type: GrantFiled: October 31, 2013Date of Patent: November 20, 2018Assignee: Catholic University Industry Academic Cooperation FoundationInventor: Hiun Suk Chae