Patents Assigned to Catholic University Industry Academy Cooperation Foundation
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Patent number: 9572786Abstract: The present invention relates to a new use of capsiate or dihydrocapsiate, more particularly to a composition for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease or for suppressing immunity comprising capsiate, dihydrocapsiate or a pharmaceutically acceptable salt thereof as an effective ingredient. The composition and immunosuppressant of the present invention may be used for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease, and for suppressing immunity.Type: GrantFiled: May 8, 2013Date of Patent: February 21, 2017Assignee: Catholic University Industry Academy Cooperation FoundationInventors: Dong Heun Shin, Young Geun Kwon, Bo Jeong Pyun, Tae-Yoon Kim
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Patent number: 9381168Abstract: The present invention relates to a new use of capsiate or dihydrocapsiate, more particularly to a composition for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease or for suppressing immunity comprising capsiate, dihydrocapsiate or a pharmaceutically acceptable salt thereof as an effective ingredient. The composition and immunosuppressant of the present invention may be used for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease, and for suppressing immunity.Type: GrantFiled: May 27, 2008Date of Patent: July 5, 2016Assignee: Catholic University Industry Academy Cooperation FoundationInventors: Dong Heun Shin, Young Guen Kwon, Bo Jeong Pyun, Tae-Yoon Kim
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Publication number: 20140336135Abstract: The present invention relates to a novel use of rhododendrin, and more particularly to a composition for antioxidant purposes or for the prevention or treatment of hyperproliferative skin disorders, which comprises rhododendrin as an active ingredient; and a method for inhibiting reactive oxygen species or for preventing and treating a hyperproliferative skin disorder, which comprises administering an effective amount of rhododendrin to a subject in need thereof. Rhododendrin is not cytotoxic and has an excellent effect of eliminating a large amount of reactive oxygen species (ROS) generated by TNF-?/IFN-? or UV light, and thus is effectively used to prepare an antioxidant cosmetic composition or an antioxidant food composition. In addition, rhododendrin has the effect of inhibiting skin cell hyperproliferation and has an excellent effect of inhibiting a hyperproliferative skin disorder or skin hyperkeratinization mediated by Toll-like receptors (TLRs) in various skin diseases, particularly psoriasis.Type: ApplicationFiled: March 21, 2014Publication date: November 13, 2014Applicant: Catholic University Industry Academy Cooperation FoundationInventors: Tae-Yoon Kim, Yoon Jea Jeon
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Patent number: 8609718Abstract: Disclosed is a novel use of phytosphingosine. More particularly, disclosed are a composition for preventing or treating hyper-proliferative skin diseases comprising pachastrissamine as an active ingredient, a use of pachastrissamine or a pharmaceutically acceptable salt thereof for preparing a preventing/therapeutic agent of hyper-proliferative skin diseases, and a method for treating hyper-proliferative skin diseases administering an effective amount of pachastrissamine or a pharmaceutically acceptable salt thereof to a subject in need thereof. The pachastrissamine inhibits the degradation of FoxO3a protein and increases the expression of FoxO3a protein. Thus, the inventive pharmaceutical composition has a preventing of treating effect on hyper-proliferative diseases by inducing apoptosis of hyper-proliferative cells and inhibiting the cell cycle.Type: GrantFiled: September 19, 2011Date of Patent: December 17, 2013Assignee: Catholic University Industry Academy Cooperation FoundationInventors: Dong Heon Shin, Tae Yoon Kim
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Patent number: 8552065Abstract: The present invention relates to a novel biarylamide derivative and a pharmaceutical composition or a cosmetic composition comprising the same as an active ingredient. More particularly, the present invention relates to a novel biarylamide derivative, a pharmaceutical composition or a cosmetic composition for preventing or treating a pigmentation disorder caused by an abnormal excess of melanin or a disease caused by melanocyte hyperplasia comprising the same as an active ingredient. The biarylamide derivative of the present invention inhibits melanin production and thus inhibits melanocyte hyperplasia. Therefore, a cosmetic composition comprising the biarylamide is excellent in a whitening effect, and a pharmaceutical composition comprising the biarylamide is effective in the prevention or treatment of pigmentation disorders of skin such as lentigo, melasma, freckle, etc. and malignant melanoma.Type: GrantFiled: July 25, 2012Date of Patent: October 8, 2013Assignee: Catholic University Industry Academy Cooperation FoundationInventor: Dong Heon Shin
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Publication number: 20130245117Abstract: The present invention relates to a new use of capsiate or dihydrocapsiate, more particularly to a composition for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease or for suppressing immunity comprising capsiate, dihydrocapsiate or a pharmaceutically acceptable salt thereof as an effective ingredient. The composition and immunosuppressant of the present invention may be used for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease, and for suppressing immunity.Type: ApplicationFiled: May 8, 2013Publication date: September 19, 2013Applicant: Catholic University Industry Academy Cooperation FoundationInventors: Dong Heun Shin, Young Geun Kim, Bo Jeong Pyun, Tae-Yoon Kim
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Publication number: 20120289595Abstract: The present invention relates to a novel biarylamide derivative and a pharmaceutical composition or a cosmetic composition comprising the same as an active ingredient. More particularly, the present invention relates to a novel biarylamide derivative, a pharmaceutical composition or a cosmetic composition for preventing or treating a pigmentation disorder caused by an abnormal excess of melanin or a disease caused by melanocyte hyperplasia comprising the same as an active ingredient. The biarylamide derivative of the present invention inhibits melanin production and thus inhibits melanocyte hyperplasia. Therefore, a cosmetic composition comprising the biarylamide is excellent in a whitening effect, and a pharmaceutical composition comprising the biarylamide is effective in the prevention or treatment of pigmentation disorders of skin such as lentigo, melasma, freckle, etc. and malignant melanoma.Type: ApplicationFiled: July 25, 2012Publication date: November 15, 2012Applicant: Catholic University Industry Academy Cooperation FoundationInventor: Dong Heon Shin
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Publication number: 20120088226Abstract: The present invention relates to a nucleic acid extracting apparatus, and the nucleic acid extracting apparatus can include a pipe-shaped tube having an open outlet at one side thereof, and a hydrogel column that is provided inside the tube and filters impurities excluding an extraction target material.Type: ApplicationFiled: June 22, 2009Publication date: April 12, 2012Applicants: CATHOLIC UNIVERSITY INDUSTRY-ACADEMY COOPERATION FOUNDATION, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Geun-Bae Lim, Ji-Min Kahng, Tae-Hee Kang, Jin-Hwa Jung
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Publication number: 20120071424Abstract: Disclosed is a novel use of phytosphingosine. More particularly, disclosed are a composition for preventing or treating hyper-proliferative skin diseases comprising pachastrissamine as an active ingredient, a use of pachastrissamine or a pharmaceutically acceptable salt thereof for preparing a preventing/therapeutic agent of hyper-proliferative skin diseases, and a method for treating hyper-proliferative skin diseases administering an effective amount of pachastrissamine or a pharmaceutically acceptable salt thereof to a subject in need thereof. The pachastrissamine inhibits the degradation of FoxO3a protein and increases the expression of FoxO3a protein. Thus, the inventive pharmaceutical composition has a preventing of treating effect on hyper-proliferative diseases by inducing apoptosis of hyper-proliferative cells and inhibiting the cell cycle.Type: ApplicationFiled: September 19, 2011Publication date: March 22, 2012Applicant: Catholic University Industry Academy Cooperation FoundationInventors: Dong Heon Shin, Tae Yoon Kim
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Publication number: 20110207807Abstract: The present disclosure relates to a new use of homoisoflavanone or a salt thereof. More particularly, it relates to a pharmaceutical composition for the prevention and treatment of inflammatory diseases or allergic diseases comprising homoisoflavanone represented by Chemical Formula 1 or a salt thereof, a use of homoisoflavanone or a salt thereof in the manufacture of an agent for the preventing and treating of inflammatory diseases or allergic diseases, and a method for treating inflammatory diseases or allergic diseases including administering an effective dose of homoisoflavanone or a salt thereof to a subject in need thereof.Type: ApplicationFiled: September 2, 2009Publication date: August 25, 2011Applicant: Catholic University Industry Academy Cooperation FoundationInventors: Tae Yoon Kim, Dong Heon Shin
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Patent number: 7939255Abstract: The present application discloses a diagnostic method and a kit for prognosis assessment of colorectal cancer (CRC) and a novel tumor suppressor gene to be used for diagnosis of colorectal cancer (CRC), the method comprising the steps of: (a) identifying recurrently altered regions (RAR) on a chromosome; and (b) detecting genomic alterations in the RAR. The present method makes it possible to perform early diagnosis as well as prognosis assessment for various cancers and tumors including colorectal cancer (CRC).Type: GrantFiled: July 3, 2007Date of Patent: May 10, 2011Assignee: Catholic University Industry Academy Cooperation FoundationInventor: Yeun-Jun Chung
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Publication number: 20090181394Abstract: The invention provides diagnostic methods for determining the prognosis of hepatocellular carcinoma (HCC) comprising the steps of (a) observing recurrently altered genomic region on a chromosome; (b) measuring variation of one or more of RAR expression variations selected from the RAR variation group consists of gains of RAR-G1 to RAR-G14 and losses of RAR-L1 to RAR-L18 as defined in table 1, a diagnostic kit, and genes for useful in diagnosis or prognosis of liver cancer.Type: ApplicationFiled: January 14, 2009Publication date: July 16, 2009Applicant: Catholic University Industry Academy Cooperation FoundationInventor: Yeun-Jun Chung
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Publication number: 20080183156Abstract: The present invention relates to a closed suction drainage apparatus with a drainage tube having anti-clogging and irrigating functions. The closed suction drainage apparatus of the present invention have a double tube structure of the drainage tube and its connection unit. One tube of the drainage tube is used for drain blood and exudates from a dead space and the other tube is used for applying positive pressure to remove clotted substance in the drainage tube or irrigating a wound with liquid. The closed suction drainage apparatus according to the present invention can easily clear the clogged drainage tube or irrigate dead space when needed, even in the state that it is inserted in the body.Type: ApplicationFiled: July 31, 2007Publication date: July 31, 2008Applicant: Catholic University Industry Academy Cooperation FoundationInventor: Gyeol Yoo
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Publication number: 20080096205Abstract: The present application discloses a diagnostic method and a kit for prognosis assessment of colorectal cancer (CRC) and a novel tumor suppressor gene to be used for diagnosis of colorectal cancer (CRC), the method comprising the steps of: (a) identifying recurrently altered regions (RAR) on a chromosome; and (b) detecting genomic alterations in the RAR. The present method makes it possible to perform early diagnosis as well as prognosis assessment for various cancers and tumors including colorectal cancer (CRC).Type: ApplicationFiled: July 3, 2007Publication date: April 24, 2008Applicant: Catholic University Industry Academy Cooperation FoundationInventor: Yeun-Jun Chung