Abstract: A biological computing platform may include a multielectrode array (MEA) connected to a computing device. The MEA may include a 2D grid of excitation sites, biological neurons disposed on the MEA, a processing device to apply a plurality of impulses at excitation sites having coordinates on the 2D grid, and one or more sensors to measure electrical signals output by one or more of the biological neurons at coordinates of the 2D grid, wherein the processing device is to receive the electrical signals from the one or more sensors and generate a representation of the electrical signals. The computing device may be programmed to receive a digital input signal, convert the digital input signal into instructions for the plurality of impulses, send the instructions to the MEA, receive the representation of the electrical signals from the MEA, and process the representation of the electrical signals.

Abstract: A closed-loop perfusion system may include a sealed biological culture container configured to house a biological cell culture, and a filtering unit that permits passage of waste products from an output of the sealed biological cell culture container, permits passage of nutrients from a nutrient media solution, and blocks passage of beneficial molecules from the output of the sealed biological cell culture container. The system may further include a first fluid path between an output of the sealed biological cell culture container and an input of the filtering unit, a second fluid path between an output of the filtering unit and an input of the sealed biological cell culture, and a pump to control the flow of media through the first fluid path and the second fluid path.

Abstract: A biological computing platform may include a multielectrode array (MEA) connected to a computing device. The MEA may include a 2D grid of excitation sites, biological neurons disposed on the MEA, a processing device to apply a plurality of impulses at excitation sites having coordinates on the 2D grid, and one or more sensors to measure electrical signals output by one or more of the biological neurons at coordinates of the 2D grid, wherein the processing device is to receive the electrical signals from the one or more sensors and generate a representation of the electrical signals. The computing device may be programmed to receive a digital input signal, convert the digital input signal into instructions for the plurality of impulses, send the instructions to the MEA, receive the representation of the electrical signals from the MEA, and process the representation of the electrical signals.