Abstract: Biomarkers are used in compositions, combinations, systems, and methods for diagnosing, staging, and monitoring and/or treatment of osteoarthritis. The biomarkers discriminate osteoarthritis from rheumatoid arthritis, crystalline arthritis, septic arthritis, and/or traumatic injury, and can be used in a differential diagnosis of joint pain and/or joint inflammation.
Type:
Grant
Filed:
October 29, 2020
Date of Patent:
June 16, 2026
Assignee:
CD DIAGNOSTICS, INC.
Inventors:
Krista Toler, James W. Stave, Michael Brown, Carolina Sepulveda, Tony Joaquim
Abstract: The invention provides methods and systems for detecting a biomarker in a synovial fluid wherein the system also includes a control to ensure that the test sample is indeed synovial fluid. The biomarkers and the control for synovial fluid can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.
Type:
Grant
Filed:
October 7, 2022
Date of Patent:
August 12, 2025
Assignee:
CD Diagnostics, Inc.
Inventors:
Carl Deirmengian, Richard C. Birkmeyer, Keith Kardos, Patrick Kilmartin, Alexander Cameron, Kevin Schiller, Eun Kyung Chung
Abstract: The invention provides methods and systems for detecting a biomarker in a synovial fluid wherein the system also includes a control to ensure that the test sample is indeed synovial fluid. The biomarkers and the control for synovial fluid can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.
Type:
Grant
Filed:
September 26, 2018
Date of Patent:
November 15, 2022
Assignee:
CD Diagnostics, Inc.
Inventors:
Carl Deirmengian, Richard C. Birkmeyer, Keith Kardos, Patrick Kilmartin, Alexander Cameron, Kevin Schiller, Eun Kyung Chung
Abstract: Various embodiments disclosed relate to a buffered aqueous solution. The buffered aqueous solution includes a buffer. The buffer includes a citrate component having a concentration in the solution in a range of from about 0.1 mM to about 600 mM. The buffer further includes a metal component having a concentration in the solution in a range of from about 0.01 mM to about 100 mM. The buffered aqueous solution has a pH in a range of from about 5 to about 9.
Type:
Grant
Filed:
September 24, 2018
Date of Patent:
September 14, 2021
Assignee:
CD DIAGNOSTICS, INC.
Inventors:
John Leon Miamidian, Martin Raymond Gould, Michael Brown
Abstract: The invention provides methods and systems for detecting a biomarker in a synovial fluid wherein the system also includes a control to ensure that the test sample is indeed synovial fluid. The biomarkers and the control for synovial fluid can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.
Type:
Grant
Filed:
October 22, 2012
Date of Patent:
November 27, 2018
Assignee:
CD Diagnostics, Inc.
Inventors:
Carl Deirmengian, Richard C. Birkmeyer, Keith Kardos, Patrick Kilmartin, Alexander Cameron, Kevin Schiller, Eun Kyung Chung
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