Abstract: The present invention is directed to somatostatin receptor antagonist compounds having the structure of Formula I, compositions comprising the same, and methods of using such compounds and compositions. The compounds may be useful in the prevention or treatment of hypoglycemia.
Type:
Grant
Filed:
February 9, 2017
Date of Patent:
March 22, 2022
Assignee:
CDRD VENTURES INC.
Inventors:
Stephen Paul Arns, James Brian Jaquith, Davy Jérémy Baudelet, Eric Roy Simonson, Richard Tom Liggins, Nag Sharwan Kumar, Tom Han Hsiao Hsieh
Abstract: Provided are humanized anti-HLA-A2 antibodies. In certain aspects, the humanized anti-HLA-A2 antibodies are capable of constituting an antigen binding domain of a chimeric antigen receptor (CAR), where the CAR is capable of being expressed in a human cell such that the CAR specifically binds to HLA-A2. Also provided are CARs that include the humanized anti-HLA-A2 antibodies. Modified cells including the antibodies and CARs, as well as methods of using such modified cells are also provided.
Type:
Application
Filed:
September 19, 2018
Publication date:
September 10, 2020
Applicants:
THE UNIVERSITY OF BRITISH COLUMBIA, CDRD VENTURES INC.
Inventors:
Megan LEVINGS, Paul ORBAN, Nicholas DAWSON, Caroline LAMARCHE, Jan Peter BERGQVIST