Patents Assigned to CE Pharm Co., LTD.
  • Preparation for natural product trabectedin
    Patent number: 11339179
    Abstract: The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: May 24, 2022
    Assignee: CE Pharm Co., Ltd.
    Inventors: Dawei Ma, Weiming He, Zhigao Zhang
  • PREPARATION FOR NATURAL PRODUCT TRABECTEDIN
    Publication number: 20210163500
    Abstract: The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.
    Type: Application
    Filed: December 11, 2018
    Publication date: June 3, 2021
    Applicant: CE Pharm Co., Ltd.
    Inventors: Dawei Ma, Weiming He, Zhigao Zhang
  • Heterocyclic carboxylic acid amide ligand and applications thereof in copper catalyzed coupling reaction of aryl halogeno substitute
    Patent number: 10759765
    Abstract: Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 1, 2020
    Assignee: CE Pharm Co., Ltd.
    Inventors: Dawei Ma, Wei Zhou, Mengyang Fan, Haibo Wu, Junli Yin, Xi Jiang, Yuntong Zhai, Songtao Niu
  • Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides
    Patent number: 10500577
    Abstract: The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: December 10, 2019
    Assignee: CE Pharm CO., LTD
    Inventors: Dawei Ma, Wei Zhou, Mengyang Fan, Haibo Wu, Junli Yin, Shanghua Xia
  • HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE
    Publication number: 20190127337
    Abstract: Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.
    Type: Application
    Filed: April 14, 2017
    Publication date: May 2, 2019
    Applicant: CE Pharm Co., LTD.
    Inventors: Dawei MA, Wei ZHOU, Mengyang FAN, Haibo WU, Junli YIN, Xi JIANG, Yuntong ZHAI, Songtao NIU