Abstract: The present invention relates to novel octapeptide compounds of general formula (I), R-AA1-cyclo(AA2-Tyr3-D-Trp4-AA5-Val6-Cys7)-Thr8-NH2??(I) As these products have a good affinity for certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) of the somatostatin receptors is (are) involved. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.

Abstract: The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal1-cyclo(Cys2-Tyr3-AA4-Lys5-Val6-Cys7)-Thr8-NH2. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.

Abstract: An initial layout of an integrated circuit device is separated into a set of definitions for use in a multiple exposure fabrication process. The separation begins with reading a portion of the initial layout and identifying one or more target features within the initial layout. Further, a first revised layout definition is created for a first mask and a second revised layout definition is created for a second mask. The first revised layout definition includes the target features inside the dark-field content. In addition, in one embodiment, the first revised layout definition includes clear areas around each target feature. The second layout definition includes one or more dark features inside the bright-field content. These dark features, when used in the multiple exposure fabrication process, will overlap the target features. The first and second masks may be binary masks, attenuated phase-shifting masks (PSMs) or a combination of a binary mask and an attenuated PSM.

Abstract: The invention relates to the isolation and cloning of the VE-cadherin promoter. It also relates to transformed cells and transgenic animals containing the VE-cadherin promoter. The VE-cadherin promoter of the invention is particularly useful for the tissue-specific expression of a gene of interest in the vascular endothelium.

Abstract: Genes coding for chimeric proteins activating polymerase III transcription, the chimeric proteins and the use thereof for detecting and analysing protein-protein interactions are described. The chimeric proteins are obtained by fusing a polypeptide which is a polymerase PolIII transcription promoter with a polypeptide which is a first member of a protein-protein interaction pair.

Abstract: An amplifier sequence and a silencer sequence of the GPIIb promoter are disclosed. The amplifier sequence includes sequence domains (I) and (II), and the silencer sequence includes sequence domain (III). The use of these sequences in genetic engineering is also described.

Abstract: Housing (1, 20) for lodging conventional flat keys or keys of a special kind (2, 2a, 2b'-2b", 2c, 2d), in a safe but removable way. The laminar housing (1, 20) is realized by elastically flexible plastic material s of a type and form like a rectangular "credit card", and it is provided with a central opening (5, 21) whose peripheral edge (10, 22) defines a space for lodging a key or more superimposed keys. At the site of the opening (5, 21), elastic seizing elements (7--7) may project out of the housing (1, 20) acting on the lateral fins of the heads (3, 3a, 3b, 3c) or on the stems (4, 4a, 4c, 4d) of the keys.

Abstract: The probe comprises two inductance windings mounted in opposition and conted to an a.c. generator, a measurement winding placed at right angles between the two inductance windings and a measurement voltage detector. A compensation winding is placed coaxially and symmetrically with the measurement winding in relation to the axis of the inductance windings, thus permitting enhanced sensitivity of the probe and a directional effect. Potential applications include continuous recording of magnetic susceptibility along a vertical borehole wall and ore sorting on a conveyor belt.

Abstract: A process for the re-utilization of the sulphate residues from the electrolytic treatment of zinc.The residues are digested hot with concentrated HCl in the presence of CaCl.sub.2. PbCl.sub.2 crystallizes on cooling. FeCl.sub.3 is extracted with TBP circulating in the direction of a series of columns and FeCl.sub.3 is extracted in a first column, washed in a second column and re-extracted a third column. The solution which issues is treated with NH.sub.3, resulting in precipitation of the majority of the hydroxides of the metals contained therein, which are subsequently separated, while Ag, Zn and Cu are complexed. Ag is precipitated with (NH.sub.4).sub.2 S.NH.sub.3 is recovered by means of lime. CaCl.sub.2 is re-cycled to the start of the process and Cu and Zn are leached together with the mineral.Application of the process to the recovery of the metals contained in the residues from the digestion of blends.