Patents Assigned to Cebix
  • Method of treating a diabetic subject having a microvascular impairment disorder by a pegylated C-peptide
    Patent number: 8962553
    Abstract: The present invention relates to PEGylated C-peptide derivatives comprising at least one PEG group attached to the N-terminus, which exhibit improved pharmacokinetic and biological activity in vivo.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: February 24, 2015
    Assignee: Cebix AB
    Inventors: John Wahren, Sheri Barrack, James Callaway, Michelle Mazzoni, Howard Foyt, Mark Daniels
  • Sustained release preparation of pro-insulin C-peptide
    Patent number: 8927489
    Abstract: The present invention provides a pharmaceutical composition for the sustained release of C-peptide. The composition is in the form of a gel containing C-peptide. The gel formation is achieved by the adjustment of pH of the composition and/or by addition of divalent metal ions. The composition does not include any other gel-forming agents. Methods for producing the composition, medical uses of the composition and products containing two or more gel compositions as a combined preparation are also encompassed.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: January 6, 2015
    Assignee: Cebix Incorporated
    Inventors: John Wahren, Anders Carlsson
  • Pegylated C-peptide
    Patent number: 8927488
    Abstract: The present invention relates to modified forms of C-peptide, and methods for their use. In one aspect, the modified forms of C-peptide comprise PEGylated C-peptide derivatives comprising at least one PEG group attached to the N-terminus, which exhibit superior pharmacokinetic and biological activity in vivo.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: January 6, 2015
    Assignee: Cebix, Inc.
    Inventors: Sheri Barrack, James Callaway, Michelle Mazzoni
  • METHODS FOR TREATING ERECTILE DYSFUNCTION IN PATIENTS WITH INSULIN-DEPENDENT DIABETES
    Publication number: 20140378394
    Abstract: The present invention relates to the development of improved methods for treating erectile dysfunction associated with diabetes. Significantly, such dosing regimens can be combined with established methods for treating sexual dysfunction, including phosphodiesterase-5 (PDE5) inhibitors such as those sold under the trademark VIAGRA® to provide for significantly improved efficacy compared to the PDE5 inhibitor alone.
    Type: Application
    Filed: June 2, 2014
    Publication date: December 25, 2014
    Applicant: CEBIX AB
    Inventor: John WAHREN
  • Pegylated C-peptide
    Patent number: 8691755
    Abstract: The present invention relates to modified forms of C-peptide, and methods for their use. In one aspect, the modified forms of C-peptide comprise PEGylated C-peptide derivatives comprising at least one PEG group attached to the N-terminus, which exhibit superior pharmacokinetic and biological activity in vivo.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: April 8, 2014
    Assignee: Cebix AB
    Inventors: Sheri Barrack, James Callaway, Michelle Mazzoni
  • METHODS AND KITS FOR PREVENTING HYPOGLYCEMIA
    Publication number: 20130345124
    Abstract: Improved methods and kits for treating the long-term complications of diabetes that reduce the risk of the patient developing hypoglycemia during C-peptide therapy. The use of such methods and kits can also maintain good glycemic control and avoid excessive weight gain that may otherwise be associated with excessive insulin administration or caloric intake during C-peptide therapy.
    Type: Application
    Filed: March 1, 2013
    Publication date: December 26, 2013
    Applicant: Cebix AB
    Inventors: John Wahren, Karin Ekberg, James Callaway
  • EXTENDED RECOMBINANT POLYPEPTIDE-MODIFIED C-PEPTIDE
    Publication number: 20130316946
    Abstract: The present invention relates to modified forms of C-peptide, and methods for their use. In one aspect, the modified forms of C-peptide comprise modified C-peptide derivatives which exhibit superior pharmacokinetic and biological activity in vivo.
    Type: Application
    Filed: May 24, 2013
    Publication date: November 28, 2013
    Applicant: Cebix, Inc.
    Inventor: Sheri BARRACK
  • PEGYLATED C-PEPTIDE
    Publication number: 20130130973
    Abstract: The present invention relates to PEGylated C-peptide derivatives comprising at least one PEG group attached to the N-terminus, which exhibit improved pharmacokinetic and biological activity in vivo.
    Type: Application
    Filed: November 19, 2012
    Publication date: May 23, 2013
    Applicant: CEBIX AB
    Inventor: CEBIX AB
  • Methods and kits for preventing hypoglycemia
    Patent number: 8410049
    Abstract: Improved methods and kits for treating the long-term complication of diabetes that reduce the risk of the patient developing hypoglycemia during C-peptide therapy. The use of such methods and kits, can also maintain good glycemic control, and avoid excessive weight gain that may otherwise be associated with excessive insulin administration or caloric intake during C-peptide therapy.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: April 2, 2013
    Assignee: Cebix
    Inventors: John Wahren, Karin Ekberg, James Callaway
  • PEGYLATED C-PEPTIDE
    Publication number: 20120220542
    Abstract: The present invention relates to modified forms of C-peptide, and methods for their use. In one aspect, the modified forms of C-peptide comprise PEGylated C-peptide derivatives comprising at least one PEG group attached to the N-terminus, which exhibit superior pharmacokinetic and biological activity in vivo.
    Type: Application
    Filed: May 4, 2012
    Publication date: August 30, 2012
    Applicant: CEBIX, INC.
    Inventors: Sheri Barrack, James Callaway, Michelle Mazzoni
  • PEGYLATED C-PEPTIDE
    Publication number: 20120178676
    Abstract: The present invention relates to modified forms of C-peptide, and methods for their use. In one aspect, the modified forms of C-peptide comprise PEGylated C-peptide derivatives comprising at least one PEG group attached to the N-terminus, which exhibit superior pharmacokinetic and biological activity in vivo.
    Type: Application
    Filed: May 17, 2011
    Publication date: July 12, 2012
    Applicant: CEBIX, INC.
    Inventors: Sheri Barrack, James Callaway, Michelle Mazzoni
  • METHODS FOR TREATING ERECTILE DYSFUNCTION IN PATIENTS WITH INSULIN-DEPENDENT DIABETES
    Publication number: 20110190192
    Abstract: The present invention relates to the development of improved methods for treating erectile dysfunction associated with diabetes. Significantly, such dosing regimens can be combined with established methods for treating sexual dysfunction, including PDE5 inhibitors such as those sold under the trademark VIAGRA® to provide for significantly improved efficacy compared to the PDE5 inhibitor alone.
    Type: Application
    Filed: December 14, 2010
    Publication date: August 4, 2011
    Applicant: Cebix Inc.
    Inventor: John Wahren
  • METHODS AND KITS FOR PREVENTING HYPOGLYCEMIA
    Publication number: 20110098220
    Abstract: The present invention provides improved methods and kits for treating the long-term complication of diabetes that reduce the risk of the patient developing hypoglycemia during C-peptide therapy. The use of such methods and kits, can also maintain good glycemic control, and avoid excessive weight gain that may otherwise be associated with excessive insulin administration or caloric intake during C-peptide therapy.
    Type: Application
    Filed: March 4, 2010
    Publication date: April 28, 2011
    Applicant: CEBIX AB
    Inventors: John Wahren, Karin Ekberg, James Callaway
  • Methods and kits for preventing hypoglycemia
    Patent number: 7855177
    Abstract: Improved methods and kits for treating the long-term complication of diabetes that reduce the risk of the patient developing hypoglycemia during C-peptide therapy. The use of such methods and kits, can also maintain good glycemic control, and avoid excessive weight gain that may otherwise be associated with excessive insulin administration or caloric intake during C-peptide therapy.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: December 21, 2010
    Assignee: Cebix Inc.
    Inventors: John Wahren, Karin Ekberg, James Callaway