Patents Assigned to Cedars-Sinai Medical Center
  • Publication number: 20200370023
    Abstract: Described herein are methods and compositions related to generation of induced pluripotent stem cells (iPSCs). Improved techniques for establishing highly efficient, reproducible reprogramming using non-integrating episomal plasmid vectors. Using the described reprogramming protocol, one is able to consistently reprogram non-T cells with close to 100% success from non-T cell or non-B cell sources. Further advantages include use of a defined reprogramming media E7 and using defined clinically compatible substrate recombinant human L-521. Generation of iPSCs from these blood cell sources allows for recapitulation of the entire genomic repertoire, preservation of genomic fidelity and enhanced genomic stability.
    Type: Application
    Filed: July 2, 2020
    Publication date: November 26, 2020
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Dhruv Sareen, Loren A. Ornelas, Clive Svendsen
  • Patent number: 10844417
    Abstract: Disclosed are methods of diagnosing constipation and constipation-predominant irritable bowel syndrome by screening for the presence of abnormally high levels of methane and/or methanogenic organisms in a subject.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: November 24, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Henry C. Lin
  • Publication number: 20200360468
    Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
    Type: Application
    Filed: May 29, 2020
    Publication date: November 19, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mark PIMENTEL, Ruchi MATHUR, Christopher CHANG
  • Patent number: 10836735
    Abstract: The invention describes compounds that inhibit both HDAC and GSK3? (i.e., HDAC/GSK3? dual inhibitors). The invention further describes compositions containing these HDAC/GSK3? dual inhibitors, as well as methods and kits using these HDAC/GSK3? dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3? to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3?. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: November 17, 2020
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Mouad Edderkaoui, Ramachandran Murali, Stephen Pandol
  • Publication number: 20200345273
    Abstract: A method for monitoring the progress of post-operative ambulation is disclosed. A patient after a surgical procedure such as an operation is provided with an ambulatory routine. The ambulatory routine is monitored using a wearable biosensor device operable to track steps of the patient. The steps of the patient in following the ambulatory routine are recorded. The ambulation data is displayed on a periodic basis to provide feedback to both the patient and health care professionals.
    Type: Application
    Filed: November 6, 2018
    Publication date: November 5, 2020
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Timothy J. Daskivich, Brennan Spiegel
  • Publication number: 20200346032
    Abstract: The disclosed technology relates to a system for delivering UV-A/B light with a catheter to treat infectious or inflammatory disorders in a patient. While UV light in the UV-C range has traditionally been used to treat skin disorders and for focused ablation of plaques in the arteries and other targeted internal uses, it has not been developed for broader infection, inflammation or neoplasia treatment inside the human body. Here, the inventor(s) developed a system for emission of therapeutic doses of UV light via a catheter, capsule, endoscope, tube or port that can be used to manage internal infections and inflammatory conditions inside a patient.
    Type: Application
    Filed: July 15, 2020
    Publication date: November 5, 2020
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed
  • Patent number: 10820989
    Abstract: In various embodiments, provided herein are methods, devices and systems for transcatheter mitral valve replacement in a double-orifice mitral valve. These methods, devices and systems are used to treat patients with mitral valve disease, particularly those who have had failed edge-to-edge leaflet repair, or patients presently considered anatomically unsuitable for edge-to-edge leaflet repair alone.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: November 3, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventor: Hasanian Al-Jilaihawi
  • Patent number: 10823736
    Abstract: A method, system and computer-readable medium for assessing a disease condition of a cancer of a subject, including: receiving a blood sample from the subject; isolating a plurality of circulating tumor cells (CTCs) from the blood sample; measuring at least one of cell or cell nucleus sizes of each of the plurality of CTCs; determining a measured CTC size distribution of the plurality of CTCs based on the measuring; comparing the measured CTC size distribution to a reference CTC size distribution using a computer; and assigning the disease condition of the cancer of the subject based on the comparing.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: November 3, 2020
    Assignees: The Regents of the University of California, Cedars-Sinai Medical Center
    Inventors: Hsian-Rong Tseng, Jiaoti Huang, Edwin M. Posadas, Jiefu Chen, Hao Ho, Zunfu Ke, Ker-Chau Li, Yi-Tsung Lu, Jake Lichterman, Min Song, Leland W. K. Chung
  • Publication number: 20200332316
    Abstract: Described herein are reprogramming techniques allowing for production of mammary-derived iPSCs (“m-iPSCs”). The m-iPSCs described herein exhibit all the hallmarks of stem cell identity including round cluster, bright colony morphology, clonal expansion, and pluripotent marker expression (alkaline phosphatase expression, Oct-4, nanog, etc.) Further refined techniques allow for generation of m-iPSCs under essentially defined conditions.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 22, 2020
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Xiaojiang Cui, Dhruv Sareen, Loren A. Ornelas
  • Publication number: 20200333339
    Abstract: Described herein are compositions and methods for diagnosing late-onset Alzheimer's disease (LOAD), treating LOAD and assessing efficacy of therapeutic agents used to treat LOAD.
    Type: Application
    Filed: August 31, 2016
    Publication date: October 22, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventor: Christopher Wheeler
  • Patent number: 10810904
    Abstract: Described herein are kits and methods for identifying the likelihood of having a food sensitivity or intolerance, and determining dietary modifications accordingly. For example, the likelihood of having sensitivities, intolerances or allergies to gluten, lactose, FODMAPs and others tested and calculated. Additionally, diet modifications can be determined according to the likelihood of particular sensitivities, and the effectiveness of diet modifications can be evaluated by monitoring of meals and subsequent symptoms, and evaluating the monitoring information. Through application of the methods herein, dietary intake and symptom data may be collected and aggregated to evaluate the effect or desirability of particular foods on a population of interest.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: October 20, 2020
    Assignees: CEDARS-SINAI MEDICAL CENTER, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Brennan Spiegel, William D. Chey
  • Publication number: 20200323781
    Abstract: The present invention relates to, in part, methods and compositions for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS). Particularly, modified-release formulations comprising at least one antimethanogenic statin are provided which release the antimethanogenic statin in the intestines.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 15, 2020
    Applicants: Cedars-Sinai Medical Center, Synthetic Biologics, Inc.
    Inventors: Mark Pimentel, Ruchi Mathur, Steve Kanzer, Vince Wacher
  • Patent number: 10801073
    Abstract: Modules, devices, systems and methods for measuring or detecting cysteine and/or methionine metabolite levels in a sample from a subject are disclosed. Various embodiments of the present invention concern modules, devices, systems and methods for prognosing or diagnosing cancer, for example, prostate, colon, ovarian or breast cancer; predicting the risk or probability of cancer recurrence; and/or for predicting, detecting and/or monitoring cystinuria or cystine stone disease.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: October 13, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Neil A. Bhowmick, Diptiman Choudhury, Michael J. Baker, Mark Sasha Drlik, Bjarne Hansen, Ayon Bhowmick
  • Patent number: 10803578
    Abstract: The invention provides systems and methods for imaging a sample. In various embodiments, the invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a visible light source, a notch beam splitter, a notch filter, a synchronization module, an image processing unit, an image displaying unit, and light-conducting channels. In various embodiments, the present invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a laser clean-up filter, a notch filter, a white light source, an image processing unit, an image displaying unit, and light-conducting channels. In accordance with the present invention, the image sensor can detect both visible light and infrared light.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: October 13, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Pramod Butte, Adam Mamelak
  • Patent number: 10799359
    Abstract: Catheter apparatuses and methods are provided for repairing heart valves, particularly mitral valves. The method includes providing a catheter having an elongate, flexible body, with a proximal end and a distal end. The distal end can be transluminally advanced from the left atrium through the mitral valve. A distal anchor zone or portion coupled with the proximal end can extend and along the left ventricular outflow tract into the ascending aorta. A valve repair device is deployed to permanently connect leaflets at a mid-section of a mitral valve while permitting medial and lateral portions of the natural leaflets to open and close. The catheter apparatuses may be positionable using a steering device. The valve repair device detachably connects the distal and proximal ends of the catheter. The valve repair device can be detached using low profile devices actuatable from the proximal or distal ends, e.g., at a venous or arterial access site.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: October 13, 2020
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Robert James Siegel, Lawrence E. Ong
  • Publication number: 20200315456
    Abstract: The invention is directed to methods for diagnosing reperfusion/non-reperfusion hemorrhage and predicting cardiac arrhythmias and sudden cardiac death in subjects comprising using imaging techniques to detect regional iron oxide deposition. The invention also provides treatment methods for subject at increased risk of sudden cardiac death.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 8, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Rohan Dharmakumar, Ivan Cokic
  • Publication number: 20200315522
    Abstract: In various embodiments, the invention teaches systems and methods for magnetic resonance imaging. In some embodiments, the invention teaches systems and methods for determining the source of pain in intervertebral discs by measuring one or more physiological biomarkers associated with disc pain and/or disc degeneration.
    Type: Application
    Filed: June 8, 2017
    Publication date: October 8, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Dan GAZIT, Debiao LI, Gadi PELLED, Zulma GAZIT, Zhengwei ZHOU
  • Publication number: 20200318162
    Abstract: The present invention describes methods of identifying subjects susceptible to fibrosis by targeting bacteria found in intestine-related adipose tissue such as creeping fat, ileal mucosa or related tissue. Based on subject's susceptibility to developing fibrosis, different intervention or treatment options can be used.
    Type: Application
    Filed: March 27, 2020
    Publication date: October 8, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Suzanne Devkota, Wing Yan Ha
  • Publication number: 20200315468
    Abstract: The invention provides various methods of identifying myocardial infarction (MI) patients who have microvascular obstruction (MO), persistent microvascular obstruction (PMO), reperfusion hemorrhage, iron deposition, chronic iron deposition, and/or fat infiltration/accumulation. The invention provides various methods of identifying myocardial infarction (MI) patients who are at risk of prolonged inflammation burden in heart, adverse cardiac remodeling, electrical abnormality, mechanical abnormality, malignant cardiac arrhythmia, ischemic heart failure, and/or sudden cardiac death. The invention also provides various methods of treating these MI patients with chelation drugs, anti-inflammatory drugs, fat-lowering drugs, cooling therapies, or device therapies, or their combinations.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 8, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Rohan Dharmakumar, Ivan Cokic
  • Patent number: 10793853
    Abstract: The present invention relates a targeted delivery system for siRNA or antisense technology. In one embodiment, the invention provides for a method of treating cancer by administering a therapeutically effective dosage of HerPBK10 combined with siRNA, resulting in the inhibition of Her2 expression and cell death. In another embodiment, a plurality of HerPBK10 combined with siRNA form a nanoparticle.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: October 6, 2020
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventor: Lali K. Medina-Kauwe