Patents Assigned to Cedars-Sinai Medical Center
  • CARDIOSPHERE-DERIVED CELLS AND EXOSOMES SECRETED BY SUCH CELLS IN THE TREATMENT OF MUSCULAR DYSTROPHY
    Publication number: 20170290860
    Abstract: Described herein are compositions and techniques related to generation and therapeutic application of cardiosphere-derived cells (CDCs) and CDC-derived exosomes. These cells and their secreted vesicles contain a unique milieu of biological factors, including cytokines, growth factors, transcription factors, nucleic acids including non-coding nucleic acids such as microRNAs, that serve to initiate and promote many therapeutic effects. Exosomes and their “cargo” contents, such as microRNAs can favorably modulate apoptosis, inflammation and fibrosis in the injured heart. Thus, CDC-derived exosomes represent a novel “cell-free” therapeutic candidate for tissue repair.
    Type: Application
    Filed: October 2, 2015
    Publication date: October 12, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventors: Eduardo Marban, Mark Amin Aminzadeh
  • Fungal mycobiome as probiotics, diagnostics and therapeutics
    Patent number: 9782389
    Abstract: The present invention relates to methods of using fungal mycobiome as a means of treating and/or diagnosing diseases in a subject. In one embodiment, the present invention provides a method of diagnosing inflammatory bowel disease based on the composition of fungal strains present in the gut of a subject, and treating the subject by administering a probiotic biotherapy. In another embodiment, the present invention provides a method of diagnosing a severe form of ulcerative colitis by detecting the presence of a deficiency in dectin-1 expression in s. fibuligera in the gut of a subject.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: October 10, 2017
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: David M. Underhill, Iliyan D. Iliev
  • EARLY LUNG CANCER DETECTION BY DNA METHYLATION PHENOTYPING OF SPUTUM-DERIVED CELLS
    Publication number: 20170283881
    Abstract: In certain embodiments, this application discloses methods for detecting lung cancer. The method includes characterization of cells extracted from human sputum, which is a valuable tissue surrogate and source of upper respiratory cells that become cancerous early in 5 the process of lung cancer development. The method includes the staining of extracted cells with fluorescent reporters that produce a specific pattern in the nuclei of labeled cells, which can be made visible by light microscopy. The pattern is relevant to a type of epigenetic coding of DNA known as DNA methylation, which changes in specific cells of the lung during cancer development, in comparison to normal respiratory cells.
    Type: Application
    Filed: August 28, 2015
    Publication date: October 5, 2017
    Applicants: Cedars-Sinai Medical Center, The Regents of the University of California
    Inventors: Jian Tajbakhsh, Fariborz Mortazavi
  • Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors
    Patent number: 9764014
    Abstract: Compositions comprising dendritic cells pulsed with tumor lysate and at least one toll-like receptor (TLR) ligand which may be used for eliciting a specific immune response in a mammal in need thereof for treating diseases including a tumor are disclosed. Also disclose are methods of activating dendritic cells, comprising providing at least one toll-like receptor (TLR) ligand; and pulsing a dendritic cell with the at least one TLR ligand. A method further comprises pulsing the dendritic cell with a tumor lysate.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: September 19, 2017
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Keith L. Black, Dwain Morris-Irvin, Moshe Arditi
  • Treatment of inflammatory conditions with hyaluronan disaccharide
    Patent number: 9763969
    Abstract: The present invention describes compositions and related methods and kits for treating a variety of inflammatory conditions and infections. The therapeutic compositions include certain hyaluronidases capable of generating hyaluronan disaccharides when combined with hyaluronan, and/or the hyaluronan disaccharides themselves, and/or inflammatory hyaluronidase inhibitors. The invention further discloses the use of hyaluronidase inhibitors to treat certain infections in an individual.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: September 19, 2017
    Assignee: Cedars-Sinai Medical Center
    Inventors: George Liu, Pierre Kyme
  • Transcription factor-based generation of pacemaker cells and methods of using same
    Patent number: 9763999
    Abstract: Several embodiments disclosed herein relate generally to methods and compositions for the generation of biological pacemakers. In some embodiments, the methods comprise contacting non-pacemaker cells with one or more transcription factors (in vivo or in vitro) and inducing pacemaker functionality in the cells.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: September 19, 2017
    Assignee: Cedars-Sinai Medical Center
    Inventors: Eduardo Marban, Hee Cheol Cho
  • Methods and apparatus for atrioventricular valve repair
    Patent number: 9763658
    Abstract: Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: September 19, 2017
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Neal L. Eigler, Matthew J. Price, Robert J. Siegel
  • Targeting corroles for tumor toxicity and MRI
    Patent number: 9757386
    Abstract: Disclosed herein are compositions comprising a targeted corrole nanoparticle; and an acceptable excipient. Also disclosed are compositions comprising a targeted corrole nanoparticle; and an acceptable carrier. Further, disclosed herein are methods of imaging a condition in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; administering an effective amount of the targeted corrole nanoparticle to the subject; and imaging the condition in the subject. In addition, disclosed herein are methods of treating cancer in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; and administering a therapeutically effective dosage of the targeted corrole nanoparticle to the subject.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 12, 2017
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventor: Lali K. Medina-Kauwe
  • Targeting microRNA miR-409-3P to treat prostate cancer
    Patent number: 9745578
    Abstract: The present invention describes methods of treating cancer, cancer metastasis, and drug resistant cancers using miRNA inhibitors; for example, inhibitors of miR-409-5p, miR-409-3p, miR-154*. Also described are methods of using the miRNA as biomarkers; for example, to predict responsiveness to a cancer drug, to detect a disease state of cancer.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: August 29, 2017
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Leland W. K. Chung, Sajni Josson, Murali Gururajan, Anjali Jain
  • Methods of diagnosis, selection, and treatment of diseases and conditions caused by or associated with methanogens
    Patent number: 9744208
    Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 29, 2017
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Mark Pimentel, Ruchi Mathur, Christopher Chang
  • METHODS FOR PROGNOSING HEART TRANSPLANT
    Publication number: 20170240965
    Abstract: Provided herein is a method, comprising: obtaining a sample from the subject; assaying the sample to detect the risk alleles at one or more SNPs; calculating a genetic risk score (GRS) of the subject based on the detected risk alleles at the one or more SNPs; determining that the subject has an increased likelihood of poor prognosis if the GRS of the subject is above the mean or median GRS of the sample population or determining that the subject has an increased likelihood of good prognosis if the GRS of the subject is the same as or above the mean or median GRS of the sample population; and selecting a therapy if poor prognosis is determined.
    Type: Application
    Filed: February 22, 2017
    Publication date: August 24, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventors: Bernice Coleman, Mark O. Goodarzi, Jon Kobashigawa
  • SYSTEMS AND METHODS FOR MAGNETIC RESONANCE BLACK-BLOOD THROMBUS IMAGING IN DETECTION OF CEREBRAL VENOUS THROMBOSIS
    Publication number: 20170224217
    Abstract: In various embodiments, the present invention teaches systems and methods for using T1-weighted black-blood MR imaging, with which a CVT can be well isolated from the surrounding tissues due to the signal suppression of flowing blood. In some embodiments, the invention teaches using black-blood imaging (3D variable-flip-angle turbo spin-echo acquisition) to directly visualize thrombi. In certain embodiments, the invention teaches using T1 weighted image contrast and isotropic sub-millimeter spatial resolution for accurate detection and staging of thrombi. In various embodiments, the invention allows for the detection of chronic thrombosis recanalization.
    Type: Application
    Filed: February 4, 2016
    Publication date: August 10, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventors: Qi Yang, Zhaoyang Fan, Debiao Li, Xunming Ji
  • Methods for detecting the presence of irritable bowel syndrome and system for diagnosing same
    Patent number: 9702884
    Abstract: Described herein are methods and systems for the detection of anti-vinculin antibodies, for determining a presence or likely presence of a gastrointestinal motility disorder, bladder motility disorder, or fibromyalgia. Further provided are methods of selecting and/or administering a therapy based on the presence or absence of anti-vinculin antibodies.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: July 11, 2017
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Christopher Chang
  • ANTIFUNGAL THERAPY FOR THE TREATMENT OF HIRSCHSPRUNG-ASSOCIATED ENTEROCOLITIS
    Publication number: 20170189474
    Abstract: The present invention provides for methods and systems for the treatment and diagnosis of Hirschsprung-associated enterocolitis. Treatment of Hirschsprung-associated enterocolitis can include providing and administering an antifungal agent or a combination of an antifungal agent and an antibiotic. Diagnosis of Hirschsprung-associated enterocolitis can include the detection of fungal species by way of qPCR.
    Type: Application
    Filed: March 16, 2017
    Publication date: July 6, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventor: Philip K. FRYKMAN
  • COMPOSITIONS AND METHODS FOR TREATING FIBROSIS
    Publication number: 20170189471
    Abstract: The invention provides methods for treating fibrosis and/or cancer in a subject in need thereof. The methods include providing a composition comprising an inhibitor of IL-4/IL-13 receptor function and administering an effective amount of the composition to the subject to treat fibrosis and/or cancer.
    Type: Application
    Filed: March 15, 2017
    Publication date: July 6, 2017
    Applicants: Cedars-Sinai Medical Center, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ramachandran Murali, Aida Habtezion, Stephen J. Pandol
  • CANCER VACCINES AND VACCINATION METHODS
    Publication number: 20170173130
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Application
    Filed: August 3, 2016
    Publication date: June 22, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Gentao Liu, Keith L. Black
  • METHOD FOR TREATING ANTIBODY-MEDIATED REJECTION POST-TRANSPLANTATION
    Publication number: 20170174760
    Abstract: Described herein are methods for treating antibody mediated rejection of transplanted organs using inhibitors of IL-6. In one embodiment, the IL-6 inhibitor is Tocilizumab and is administered simultaneously or sequentially with intravenous immunoglobulin (IVIG).
    Type: Application
    Filed: March 2, 2017
    Publication date: June 22, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventors: Stanley C. Jordan, Ashley Vo, Jua Choi
  • METHODS OF USING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE TL1A GENE TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE
    Publication number: 20170166967
    Abstract: This invention provides methods of diagnosing or predicting susceptibility to Inflammatory Bowel Disease by determining the presence or absence of genetic variants in the TL1A gene. In one embodiment, a method of the invention is practiced by determining the presence or absence of TL1A production following Fc-gamma-R activation. In another embodiment, the invention provides methods of treatment of inflammatory bowel disease by inhibition of TL1A.
    Type: Application
    Filed: August 24, 2016
    Publication date: June 15, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventors: Jerome I. Rotter, Kent D. Taylor, Marla Dubinsky, Stephan R. Targan
  • METHODS AND KITS FOR IDENTIFYING FOOD SENSITIVITIES AND INTOLERANCES
    Publication number: 20170148349
    Abstract: Described herein are kits and methods for identifying the likelihood of having a food sensitivity or intolerance, and determining dietary modifications accordingly. For example, the likelihood of having sensitivities, intolerances or allergies to gluten, lactose, FODMAPs and others tested and calculated. Additionally, diet modifications can be determined according to the likelihood of particular sensitivities, and the effectiveness of diet modifications can be evaluated by monitoring of meals and subsequent symptoms, and evaluating the monitoring information. Through application of the methods herein, dietary intake and symptom data may be collected and aggregated to evaluate the effect or desirability of particular foods on a population of interest.
    Type: Application
    Filed: July 9, 2015
    Publication date: May 25, 2017
    Applicants: Cedars-Sinai Medical Center, The Regents of the University of Michigan
    Inventors: Brennan Spiegel, William D. Chey
  • Method and system for “push-button” comprehensive cardiac MR examination using continuous self-gated 3D radial imaging
    Patent number: 9655522
    Abstract: The present invention teaches systems and methods for a simple cardiac MRI approach that (1) continuously acquires data; (2) covers the entire heart with high isotropic resolution within a few minutes; and (3) requires no physiological gating and minimal user intervention. Applications of the inventive systems and methods include, but are in no way limited to cardiac cine, myocardial perfusion, coronary MRA, delayed enhancement imaging, myocardial T1-weighted imaging for fibrosis imaging, and myocardial T2-weighted imaging for edema imaging.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: May 23, 2017
    Assignee: Cedars-Sinai Medical Center
    Inventors: Debiao Li, Behzad Sharif, Daniel S. Berman, Jianing Pang