Patents Assigned to Cedars-Sinai Medical Center
  • Internal ultraviolet therapy
    Patent number: 11179575
    Abstract: A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: November 23, 2021
    Assignee: Cedars-Sinai Medical Center
    Inventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed, Ruchi Mathur, Gabriela Guimaraes Sousa Leite
  • Method of enriching a target nucleic acid at a TNFRSF1B gene locus in a sample from a subject with inflammatory bowel disease
    Patent number: 11180565
    Abstract: The aspects disclosed herein describe methods of identifying a subject that is non-responsive to anti-TNF therapy. The aspects disclosed herein further provide for a method of selecting a therapy for a subject with Inflammatory Bowel Disease (IBD), and treating the subject with the therapy.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: November 23, 2021
    Assignee: Cedars-Sinai Medical Center
    Inventors: Dermot McGovern, Stephan Targan, Dalin Li
  • HYDRAULIC SYRINGE
    Publication number: 20210353868
    Abstract: A positive pressure hydraulic aspiration syringe is provided. The syringe includes a syringe barrel having a proximal end, a distal end and an inner surface extending there between, a terminal orifice having an inner surface extending from the inner surface of the syringe barrel, a plunger having a proximal end, a distal end, and a sidewall extending there between. The plunger is slidably inserted in the syringe barrel such that the sidewall of the plunger forms a moveable seal against the inner surface of the syringe barrel. The syringe also includes a first piston configured to be displaced as the plunger is slidably inserted in the syringe barrel, a second piston mechanically linked to the first piston. Displacement of the first piston causes displacement of the second piston in an opposite direction of the plunger, which creates a negative pressure vacuum at the terminal orifice.
    Type: Application
    Filed: September 9, 2019
    Publication date: November 18, 2021
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventor: Abdul Ali Qaderi
  • Microfluidic model of the blood brain barrier
    Patent number: 11174462
    Abstract: The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: November 16, 2021
    Assignees: EMULATE, Inc., Cedars-Sinai Medical Center
    Inventors: S. Jordan Kerns, Norman Wen, Carolina Lucchesi, Christopher David Hinojosa, Jacob Fraser, Geraldine Hamilton, Gad Vatine, Samuel Sanees, Clive Svendsen, Daniel Levner, Dhruv Sareen
  • Method of classifying and diagnosing cancer
    Patent number: 11174518
    Abstract: The invention provides various methods for classifying prostate cancers into subtypes. The classification methods may be used to diagnose or prognose prostate cancers. In one embodiment, the subtypes are PCS1, PCS2, or PCS3. In one embodiment, the PCS1 subtype is most likely to progress to metastatic disease or prostate cancer specific mortality when compared to the PCS2 subtype or PCS3 subtype. In one embodiment, the PCS1 subtype is resistant to enzalutamide.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: November 16, 2021
    Assignee: Cedars-Sinai Medical Center
    Inventors: Sungyong You, Michael Freeman, Jayoung Kim, Beatrice Knudsen
  • SYSTEM AND METHOD FOR INTEGRATED TIME-RESOLVED 4D FUNCTIONAL AND ANATOMICAL MRI
    Publication number: 20210349167
    Abstract: A magnetic resonance imaging method is includes collecting spatially encoded data from a subject using an MRI system, and directly extracting a number of temporal basis functions using at least a first portion of the spatially encoded data. The method further includes, after directly extracting the number of temporal basis functions, iteratively calculating a number of coefficient images using the number of temporal basis functions and at least a second portion of the spatially encoded data. Finally, the method includes generating a 4D image based on the number of temporal basis functions and the number of coefficient images.
    Type: Application
    Filed: April 30, 2021
    Publication date: November 11, 2021
    Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, CEDARS-SINAI MEDICAL CENTER
    Inventors: YIJEN LIN WU, ANTHONY CHRISTODOULOU
  • Methods for treating nephrotic syndrome
    Patent number: 11149091
    Abstract: Described herein are methods for treating nephrotic syndrome using an anti-CD20 antibody. In one embodiment, that anti-CD20 antibody is Obinutuzumab.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: October 19, 2021
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Stanley Jordan, Ashley Vo, Jua Choi
  • Methods of treating gastrointestinal malignancies
    Patent number: 11149300
    Abstract: The present invention provides for the treatment of gastrointestinal malignancies such as pancreatic cancer. The treatment includes a combination of Poly (ADP-ribose) polymerase (PARP) inhibitor, radiation therapy, and chemotherapy. The invention also provides methods of identifying patients with DNA pathway repair gene defects who will benefit from the treatment methods described.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: October 19, 2021
    Assignee: Cedars-Sinai Medical Center
    Inventor: Richard Tuli
  • Methods of treating Crohn's disease or ulcerative colitis by administering inhibitors of tumor necrosis factor-like cytokine 1A (TL1A)
    Patent number: 11136386
    Abstract: Provided are methods, systems, and kits for selecting a patient for treatment with a therapeutic agent based on a presence of a genotype associated with a positive therapeutic response to the therapeutic agent. The therapeutic agent, in some embodiments, is an inhibitor of TL1A activity or expression, such as for example, an anti-TL1A antibody.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: October 5, 2021
    Assignees: PROMETHEUS BIOSCIENCES, INC., CEDARS-SINAI MEDICAL CENTER
    Inventors: Laurens Kruidenier, Mahyar Sabripour, Janine Bilsborough, Dermot P. McGovern, Dalin Li
  • Assessment of coronary heart disease with carbon dioxide
    Patent number: 11129911
    Abstract: There are provided methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. There are also provided methods for increasing sensitivity and specificity of BOLD MRI.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: September 28, 2021
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Rohan Dharmakumar, Debiao Li, Sotirios A. Tsaftaris
  • PEPTIDE COMPOSITIONS FOR IMMUNO-ONCOLOGY MOLECULAR IMAGING AND TARGETED DRUG DELIVERY
    Publication number: 20210284689
    Abstract: Described herein is a peptide, a multimodal peptide ligand imaging agent and methods for use in tumor targeting, tumor visualization, drug delivery and as an imaging ligand. The invention further provides for a theranostic peptide agent and methods for use in the treatment of cancer and/or inflammation in a subject.
    Type: Application
    Filed: June 7, 2018
    Publication date: September 16, 2021
    Applicant: Cedars-Sinai Medical Center
    Inventors: Yong YUE, Yi ZHANG
  • COMPACT MECHANICAL SYRINGE EXTRUDER FOR 3D BIOPRINTING OF CELL LADEN GELS
    Publication number: 20210269776
    Abstract: Bioprinting is the layer-by-layer construction of synthetic tissues or scaffolds. Described herein is a motorized extruder which can precisely extrude and retract extrudate such as bioinks in a compact and rapidly-loadable form-factor. This includes a compact bioprinter using a stepper motor coupled with a threaded shaft to directly move the plunger of an extruder. This pneumatic-mechanical system obviates the needs for pneumatic tubing, rods, or other complex elements of existing designs. The direct drive design further allows for a lighter, smaller gantry that is capable of more precise fabrication of bioprinted constructions. This includes delicate vasculature systems that are beyond limits of existing bioprinting technologies.
    Type: Application
    Filed: June 26, 2019
    Publication date: September 2, 2021
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Andrew R. Gross, Dhruv Sareen
  • Role of citrullination in diagnosing diseases
    Patent number: 11105817
    Abstract: Provided herein are methods and markers for diagnosing cardiovascular disease and/or neurodegenearative diseases in a subject. The methods include obtaining a biological sample from a subject in need of diagnosis and detecting the amount of a citrullinated protein or a citrullinated peptide in the biological sample obtained from said subject.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: August 31, 2021
    Assignee: Cedars-Sinai Medical Center
    Inventors: Jennifer Van Eyk, Justyna Fert-Bober, Erin Crowgey, Ronald Holewinski, Benjamin Phillip Berman
  • COMPOSITIONS AND METHODS TARGETING GLUTAMINE AND ITS METABOLISM FOR DIAGNOSING AND TREATING CANCER AND THERAPY-ASSOCIATED SIDE EFFECTS
    Publication number: 20210260057
    Abstract: The present disclosure provides compositions, markers, and methods for diagnosing and treating cancer and other conditions. The method includes administering at least one androgen deprivation therapy to the subject; and administering a therapeutically effective amount of at least one inhibitor to the subject, wherein the at least one inhibitor is selected from the group including: at least one macropinocytosis inhibitor, at least one glutamine metabolism inhibitor, at least one glutaminase inhibitor, and any combinations thereof.
    Type: Application
    Filed: July 12, 2019
    Publication date: August 26, 2021
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Neil Bhowmick, Rajeev Mishra, Bethany Smith
  • TRANSCRIPTION FACTOR-BASED GENERATION OF PACEMAKER CELLS AND METHODS OF USING SAME
    Publication number: 20210260158
    Abstract: Several embodiments disclosed herein relate generally to methods and compositions for the generation of biological pacemakers. In some embodiments, the methods comprise contacting non-pacemaker cells with one or more transcription factors (in vivo or in vitro) and inducing pacemaker functionality in the cells.
    Type: Application
    Filed: March 8, 2021
    Publication date: August 26, 2021
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Eduardo Marban, Hee Cheol Cho
  • INTERLEUKIN-1 INHIBITION FOR COMBINATION TREATMENT OF PANCREATIC CANCER CACHEXIA
    Publication number: 20210230268
    Abstract: A composition for IL-1 inhibition in combination with cancer therapies (e.g., chemotherapeutics including chemotherapy protective drugs) is provided for use in treating pancreatic cancer cachexia in patients, so as to reduce weight loss and improve the quality of life and survival of the patients. In one embodiment, the IL-1 inhibitor is an antibody, such as bermekimab, anakinra, canakinumab, gevokizumab, or rilonacept, administered simultaneously or sequentially with iritenocan, 5-fluorouracil and folinic acid to a pancreatic cancer patient.
    Type: Application
    Filed: March 19, 2021
    Publication date: July 29, 2021
    Applicant: Cedars-Sinai Medical Center
    Inventor: Andrew Hendifar
  • Methods of treating or preventing alzheimer's disease and associated conditions
    Patent number: 11058720
    Abstract: The present invention describes a method of treating, preventing, reducing the likelihood of or alleviating a symptom of Alzheimer's disease and associated conditions by increasing OPN expression. The invention further provides for a method of improving cognitive function in a subject in need thereof.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: July 13, 2021
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Maya Koronyo, Altanchimeg Rentsendorj, Yosef Koronyo, Keith Black
  • METHODS FOR OPTIMIZING THE TIMING OF FOOD INGESTION THROUGH MONITORING OF ACOUSTICAL ACTIVITY OF THE ABDOMINAL REGION
    Publication number: 20210186415
    Abstract: Described herein are methods and systems for monitoring acoustical activity from the abdominal region to guide the optimal timing of food ingestion. According to one embodiment of the method, the rate of intestinal digestion events, as well as the change in the rate across specific time periods, is analyzed to guide ingestion behavior in a way that improves health. The result of guidance may be to reduce weight in people who are obese, to improve performance in athletes seeking to balance energy availability and energy expenditure, or to increase caloric intake in people who are undernourished. The method can be applied using a smartphone application to provide contextually appropriate and specific user guidance about whether, when, and how much to eat in a manner that aligns with the physiologic patterns of intestinal activity.
    Type: Application
    Filed: May 2, 2018
    Publication date: June 24, 2021
    Applicant: Cedars-Sinai Medical Center
    Inventors: Brennan Spiegel, Christopher Almario
  • Biomarkers of myocardial injury
    Patent number: 11041865
    Abstract: The present invention relates to the field of myocardial injury. More specifically, the present invention provides methods and compositions useful in the diagnosis, prognosis and/or assessment of myocardial injury. In a specific embodiment, a method comprises the steps of (a) diagnosing a subject as having myocardial injury based on the statistically significant over expression of one or more markers described herein compared to a baseline value, wherein the markers are measured in a biological sample obtained from the subject; and (b) treating the subject with one or more of an anti-thrombolysis agent, coronary bypass surgery or angioplasty.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: June 22, 2021
    Assignees: THE JOHNS HOPKINS UNIVERSITY, CEDARS-SINAI MEDICAL CENTER
    Inventors: Qin Fu, Jennifer Eileen Van Eyk, Vidya Venkatraman
  • Methods and compositions for cryopreservation of endothelial cells
    Patent number: 11039610
    Abstract: Brain microvascular endothelial cells (BMECS) can be generated from pluripotent stem cells, and possess membrane barrier functions along with capability for maturation into other developing tissues. This cell type has not been successfully frozen with loss of significant viability and/or BMEC functional properties. For example, BMECs can be used to model barrier function in blood brain barrier, by calculating the trans-endothelial resistance (TEER). However, thawed primary BMECs lose TEER resistance. By optimizing cell preparation, freezing media selection, and the controlled freezing, the Inventors have achieved complete recovery of frozen cells, achieving proper tight junction protein expression and physiologically relevant TEER. The freezing methods and compositions described herein, thereby allow for BMECs to be manufactured, frozen and distributed at scale.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: June 22, 2021
    Assignee: Cedars-Sinai Medical Center
    Inventors: Samuel Sances, Gad Vatine, Brandon Shelley