Abstract: The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.
Type:
Grant
Filed:
February 11, 2008
Date of Patent:
April 23, 2013
Assignees:
celares GmbH, Scil Proteins GmbH
Inventors:
Ralf Kraehmer, Frank Leenders, Erik Fiedler, Thomas Hey, Ulrike Fiedler, Markus Fiedler