Abstract: The invention relates to the use of extract of selenium-enriched yeast (Se-YE) as a supplement to the serum-free cell culture media formulations. The cell culture media comprising this supplement are particularly suitable for cultivating mammalian cells and for production of recombinant proteins and monoclonal antibodies.

Abstract: Soluble recombinant CD44 hyaluronic acid binding domain (CD44HABD) inhibits angiogenesis in vivo in chick and mouse and thereby inhibits human tumor growth of various origins. The anti-angiogenic effect of CD44-HABD is independent of hyaluronic acid (HA) binding, since non-HA-binding mutants of CD44HABD still maintain anti-angiogenic properties. The invention discloses soluble non glycosylated CD44 recombinant proteins as a novel class of angiogenesis inhibitors based on targeting of vascular cell surface receptor. A method of block of angiogenesis and treatment of human tumors using recombinant CD44 proteins as well as their analogues is disclosed. As a further embodiment of the invention, methods for screening for new drug targets using CD44 recombinant proteins and their analogues are presented.

Abstract: The present invention relates to a method of treatment of malignant neoplasms and to a complex preparation having antineoplastic activity for use in such treatment. The complex preparation comprises alpha-fetoprotein (AFP), a polyene antibiotic, mainly amphotericin B or nystatin, and a saccharide filler, mainly glucose or dextran 40, dextran 70 and dextran 100, wherein a mass ratio of the AFP to the polyene antibiotic to the saccharide filler is 1:(60-100):(50-70). The method of treatment comprises parenteral injection to a patient in need of such treatment with the said complex preparation in a course of 10 injections once in three days.