Abstract: Dosage forms for oral administration of a methylphenidate drug are provided. The dosage forms provide a substantially immediate dose of methylphenidate upon ingestion, followed by one or more additional doses at predetermined times. By providing such a drug release profile, the dosage forms eliminate the need for a patient to carry an additional dose for ingestion during the day. The dosage forms and methods provided are useful in administering methylphenidate and pharmaceutically acceptable salts thereof, which generally require one or more doses throughout the day.
Type:
Grant
Filed:
March 11, 1998
Date of Patent:
October 21, 2003
Assignee:
Celegene Corporation
Inventors:
Atul M. Mehta, Andrew L. Zeitlin, Maghsoud M. Dariani
Abstract: Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
Type:
Grant
Filed:
May 24, 2001
Date of Patent:
August 5, 2003
Assignee:
Celegene Corporation
Inventors:
Maghsoud M. Dariani, Andrew L. Zeitlin, Jerome B. Zeldis
Abstract: Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
Type:
Grant
Filed:
September 29, 1997
Date of Patent:
July 13, 1999
Assignee:
Celegene Corporation
Inventors:
Maghsoud M. Dariani, Andrew L. Zeitlin, Jerome B. Zeldis