Patents Assigned to Celexion, LLC
  • Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
    Patent number: 9102961
    Abstract: Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: August 11, 2015
    Assignee: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia, Shaun M. Lippow
  • Biological synthesis of difunctional alkanes from carbohydrate feedstocks
    Patent number: 9062314
    Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: June 23, 2015
    Assignee: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia
  • ENGINEERED NUCLEASES AND THEIR USES FOR NUCLEIC ACID ASSEMBLY
    Publication number: 20150024464
    Abstract: Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the recognition site. Engineered endonucleases of the invention are useful for manipulating long pieces of DNA.
    Type: Application
    Filed: May 5, 2014
    Publication date: January 22, 2015
    Applicant: Celexion, LLC
    Inventors: Shaun M. Lippow, Dasa Lipovsek, Patricia M. Aha
  • BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL HEXANES AND PENTANES FROM CARBOHYDRATE FEEDSTOCKS
    Publication number: 20140212934
    Abstract: Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
    Type: Application
    Filed: April 9, 2014
    Publication date: July 31, 2014
    Applicant: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia, Shaun M. Lippow
  • BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL ALKANES FROM CARBOHYDRATE FEEDSTOCKS
    Publication number: 20140206069
    Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
    Type: Application
    Filed: March 20, 2014
    Publication date: July 24, 2014
    Applicant: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia
  • Biological synthesis of difunctional alkanes from carbohydrate feedstocks
    Patent number: 8778642
    Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: July 15, 2014
    Assignee: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia
  • Engineered nucleases and their uses for nucleic acid assembly
    Patent number: 8748146
    Abstract: Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the recognition site. Engineered endonucleases of the invention are useful for manipulating long pieces of DNA.
    Type: Grant
    Filed: April 19, 2008
    Date of Patent: June 10, 2014
    Assignee: Celexion, LLC
    Inventors: Shaun Lippow, Dasa Lipovsek, Patricia M. Aha
  • Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
    Patent number: 8722385
    Abstract: Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 13, 2014
    Assignee: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia, Shaun Lippow
  • Cell surface display, screening and production of proteins of interest
    Patent number: 8722586
    Abstract: Aspects of the invention provide compositions and methods for displaying engineered polypeptides on a cell surface. According to aspects of the invention, immobilized polypeptides can be screened to identify one or more variants having one or more functional or structural properties of interest. Aspects of the invention provide composition and methods for producing engineered protein or protein variants having a functional or a structural property of interest.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: May 13, 2014
    Assignee: Celexion, LLC
    Inventors: James A. Rakestraw, Stan I. Letovsky, Shaun Lippow
  • Cell surface display, screening and production of proteins of interest
    Patent number: 8709980
    Abstract: Aspects of the invention provide compositions and methods for displaying engineered polypeptides on a cell surface. According to aspects of the invention, immobilized polypeptides can be screened to identify one or more variants having one or more functional or structural properties of interest. Aspects of the invention provide composition and methods for producing engineered protein or protein variants having a functional or a structural property of interest.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: April 29, 2014
    Assignee: Celexion, LLC
    Inventors: James A. Rakestraw, Stan I. Letovsky, Shaun Lippow
  • Biological synthesis of 6-aminocaproic acid from carbohydrate feedstocks
    Patent number: 8404465
    Abstract: Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: March 26, 2013
    Assignee: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia, Shaun M. Lippow
  • Biological Synthesis of Difunctional Hexanes and Pentanes from Carbohydrate Feedstocks
    Publication number: 20130017593
    Abstract: Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Applicant: Celexion, LLC
    Inventors: Brain M. Baynes, John Michael Geremia, Shaun M. Lippow
  • BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL ALKANES FROM CARBOHYDRATE FEEDSTOCKS
    Publication number: 20120258504
    Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
    Type: Application
    Filed: June 4, 2012
    Publication date: October 11, 2012
    Applicant: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia
  • BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL ALKANES FROM CARBOHYDRATE FEEDSTOCKS
    Publication number: 20120164702
    Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
    Type: Application
    Filed: March 5, 2012
    Publication date: June 28, 2012
    Applicant: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia
  • Biological synthesis of difunctional alkanes from carbohydrate feedstocks
    Patent number: 8192976
    Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: June 5, 2012
    Assignee: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia
  • Biological synthesis of difunctional alkanes from carbohydrate feedstocks
    Patent number: 8133704
    Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: March 13, 2012
    Assignee: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia
  • Biological Synthesis of Difunctional Alkanes from Carbohydrate Feedstocks
    Publication number: 20110171696
    Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
    Type: Application
    Filed: March 18, 2011
    Publication date: July 14, 2011
    Applicant: Celexion, LLC
    Inventors: Brian M. Baynes, John Michael Geremia