Abstract: Described are recombinant immunoreceptors composed of an extracellular antigen binding domain (scFv) and a transmembrane region derived from the CD3?-chain and/or the Fc?RI?-chain linked to an intracellular signaling domain with cell activation properties. Moreover, nucleic acid sequences encoding said immunoreceptor, immune cells expressing said immunoreceptor as well as therapeutic uses of said immunoreceptor, e.g. adoptive immunotherapy, are described.
Type:
Application
Filed:
June 17, 2004
Publication date:
June 2, 2005
Applicant:
Cell Center Cologne GmbH
Inventors:
Andreas Hombach, Hinrich Abken, Claudia Heuser