Patents Assigned to Cell Cure Neurosciences Ltd.
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Patent number: 12203097Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.Type: GrantFiled: June 22, 2021Date of Patent: January 21, 2025Assignee: CELL CURE NEUROSCIENCES LTD.Inventors: Osnat Bohana-Kashtan, Ofer Wiser
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Patent number: 12188047Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.Type: GrantFiled: October 26, 2016Date of Patent: January 7, 2025Assignees: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD., CELL CURE NEUROSCIENCES LTD.Inventors: Benjamin Eithan Reubinoff, Orna Singer, Osnat Bohana-Kashtan, Ofer Wiser
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Patent number: 11987810Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.Type: GrantFiled: December 8, 2021Date of Patent: May 21, 2024Assignee: CELL CURE NEUROSCIENCES LTD.Inventors: Osnat Bohana-Kashtan, Lior Ann Rosenberg Belmaker, Ofer Wiser
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Patent number: 11891622Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.Type: GrantFiled: December 30, 2015Date of Patent: February 6, 2024Assignee: CELL CURE NEUROSCIENCES LTD.Inventors: Osnat Bohana-Kashtan, Lior Ann Rosenberg Belmaker, Ofer Wiser
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Patent number: 11090337Abstract: A method of generating photoreceptors is disclosed. Cell populations comprising photoreceptors and uses thereof are also disclosed.Type: GrantFiled: August 4, 2016Date of Patent: August 17, 2021Assignee: CELL CURE NEUROSCIENCES LTDInventor: Osnat Bohana-Kashtan
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Patent number: 11066642Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.Type: GrantFiled: August 4, 2016Date of Patent: July 20, 2021Assignee: Cell Cure Neurosciences LTDInventors: Osnat Bohana-Kashtan, Ofer Wiser
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Patent number: 11035857Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.Type: GrantFiled: March 28, 2017Date of Patent: June 15, 2021Assignees: Hadasit Medical Research Services and Development Ltd., Cell Cure Neurosciences Ltd.Inventors: Benjamin Eithan Reubinoff, Nurit Yachimovich-Cohen, Limor Matzrafi
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Publication number: 20210000102Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.Type: ApplicationFiled: December 28, 2018Publication date: January 7, 2021Applicant: Cell Cure Neurosciences Ltd.Inventors: Nir NETZER, Ofer WISER, Bat SHAHAF, Orit GAMBURG, Lior ROSENBERG BELMAKER, Dana HAYOUN NEEMAN, Osnat BOHANA KASHTAN
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Publication number: 20190137482Abstract: A method of determining whether an agent is a neuroeffector is disclosed. The method comprises: (a) labeling dopaminergic neurons which are comprised in a mixed population of cells with a fluorescent dopamine analog; (b) measuring a level of fluorescence in the mixed population of cells; (c) exposing the mixed population of cells to the agent; (d) remeasuring a level of fluorescence in the mixed population of cells, wherein a change in the level of fluorescence is indicative of the substance being a neuroeffector.Type: ApplicationFiled: January 8, 2019Publication date: May 9, 2019Applicants: Cell Cure Neurosciences Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Talya MORDECHAI DANIEL, Ofer WISER, Benjamin Eithan REUBINOFF
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Publication number: 20180312805Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.Type: ApplicationFiled: October 26, 2016Publication date: November 1, 2018Applicants: CELL CURE NEUROSCIENCES LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.Inventors: Benjamin Eithan REUBINOFF, Orna SINGER, Osnat BOHANA-KASHTAN, Ofer WISER
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Publication number: 20180228846Abstract: A method of generating photoreceptors is disclosed. Cell populations comprising photoreceptors and uses thereof are also disclosed.Type: ApplicationFiled: August 4, 2016Publication date: August 16, 2018Applicant: CELL CURE NEUROSCIENCES LTDInventor: Osnat BOHANA-KASHTAN
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Publication number: 20180230426Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.Type: ApplicationFiled: August 4, 2016Publication date: August 16, 2018Applicant: CELL CURE NEUROSCIENCES LTD.Inventors: Osnat Bohana-Kashtan, Ofer Wiser
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Publication number: 20170199190Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.Type: ApplicationFiled: March 28, 2017Publication date: July 13, 2017Applicants: Cell Cure Neurosciences Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Benjamin Eithan REUBINOFF, Nurit YACHIMOVICH-COHEN, Limor MATZRAFI
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Patent number: 9658216Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.Type: GrantFiled: January 29, 2013Date of Patent: May 23, 2017Assignees: Cell Cure Neurosciences Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Benjamin Eithan Reubinoff, Nurit Yachimovich-Cohen, Limor Matzrafi