Patents Assigned to Cell Design Labs, Inc.
  • Methods and compositions for reducing the immunogenicity of chimeric notch receptors
    Patent number: 11325957
    Abstract: The present invention relates to methods and compositions for reducing the immunogenicity of chimeric Notch receptors, and specifically to transcription factors useful for controlling gene expression delivered to tissues by such chimeric Notch receptors.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: May 10, 2022
    Assignee: Cell Design Labs, Inc.
    Inventors: Amy Gilbert, Vladimir Slepushkin, Peter Emtage, Anselm Levskaya, Spencer Scott
  • Chimeric polypeptides and methods of altering the membrane localization of the same
    Patent number: 11111310
    Abstract: Methods and compositions are provided for reversibly localizing proteins to the exterior part of the cell surface. Compositions provided herein can include nucleic acids that encode polypeptides of interest and the ligand binding domain (LBD) of a nuclear hormone receptor. Medical applications are provided, including controlling the toxicity of CAR T cells.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: September 7, 2021
    Assignee: Cell Design Labs, Inc.
    Inventors: Stephen Santoro, Scott Coyle, Levi Rupp, Peter Emtage