Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
Type:
Grant
Filed:
May 8, 2008
Date of Patent:
July 27, 2010
Assignee:
Cell Matrix, Inc.
Inventors:
Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
Type:
Grant
Filed:
February 15, 2008
Date of Patent:
July 27, 2010
Assignee:
Cell Matrix, Inc.
Inventors:
Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
Type:
Application
Filed:
February 15, 2008
Publication date:
September 25, 2008
Applicant:
Cell Matrix, Inc.
Inventors:
Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
Type:
Grant
Filed:
December 6, 2001
Date of Patent:
June 24, 2008
Assignee:
Cell Matrix, Inc.
Inventors:
Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
Type:
Grant
Filed:
November 26, 2001
Date of Patent:
April 29, 2008
Assignee:
Cell Matrix, Inc.
Inventors:
Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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