Patents Assigned to CELL2IN, INC.
  • Method for improving quality of therapeutic cell through real-time glutathione measurement
    Patent number: 11841369
    Abstract: The present invention relates to a method of improving the quality of therapeutic cells by real-time glutathione monitoring.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: December 12, 2023
    Assignee: Cell2In, Inc.
    Inventors: Heun Soo Kang, Hye Mi Kim, Ji Eun Song, Gwang Mo Yang, Ji Woong Shin, Hye Won Kang, Yong Hwan Kim, Myung Jin Kim
  • Method for measuring quality of therapeutic cell through real-time glutathione measurement
    Patent number: 11499978
    Abstract: The present invention provides a method of measuring the quality of therapeutic cells through real-time glutathione monitoring.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: November 15, 2022
    Assignee: CELL2IN, INC.
    Inventors: Heun Soo Kang, Hye Mi Kim, Ji Eun Song, Gwang Mo Yang, Ji Woong Shin, Hye Won Kang, Yong Hwan Kim, Myung Jin Kim
  • Real-time fluorescence imaging sensor for measuring glutathione in organelle and preparation method therefor
    Patent number: 11472825
    Abstract: The present invention relates to a real-time fluorescence imaging sensor for measuring glutathione in cell organelles and a method for fabricating the same. More specifically, the present invention relates to a novel compound for measuring glutathione in cell organelles, a method for preparing the novel compound, a real-time fluorescence imaging sensor for measuring glutathione in cell organelles, which comprises the novel compound, a method for fabricating the imaging sensor, and a method of measuring glutathione in cell organelles by use of the imaging sensor. When the composition comprising the compound according to the present invention is used, it can measure the antioxidant activity of the organelle mitochondria or Golgi apparatus in living cells, particularly stem cells, and can screen highly active stem cells based on the results obtained by measuring the antioxidant activity of the cell organelle.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: October 18, 2022
    Assignee: CELL2IN, INC.
    Inventors: Heun Soo Kang, Hye Mi Kim, Ji Eun Song, Myoung Jin Kim, Ki Hang Choi
  • Real-time imaging sensor for measuring cellular thiol level
    Patent number: 10620215
    Abstract: The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: April 14, 2020
    Assignees: Cell2In, Inc., Korea University Reserach and Business Foundation, SNU R&DB Foundation
    Inventors: In-Gyu Kim, Ki Hang Choi, Eui Man Jeong, Heun Soo Kang
  • Real-time imaging sensor for measuring cellular thiol level
    Patent number: 10215757
    Abstract: The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: February 26, 2019
    Assignees: CELL2IN, INC., SNU R&DB FOUNDATION, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: In-Gyu Kim, Ki Hang Choi, Eui Man Jeong, Heun Soo Kang