Abstract: A process for the manufacture of anatomical models which, from images obtained and the creation of editable and printable files, includes a sub-process for generating main moulds, a sub-process for generating internal elements, a sub-process for positioning the internal elements which when these include soft elements comprises a step of reversible stiffening, a sub-process for integrating the internal elements comprising a step of pouring of parenchyma and an demoulding step and a post-processing sub-process.