Abstract: Aspects of the present application provide methods for analyzing tissue samples. The methods may include disposing a tissue sample on a surface. The tissue sample may be imaged. In certain aspects, nucleic acids from the tissue sample may also be analyzed. In some such aspects, the surface can include a plurality of capture sites that contain single-stranded oligonucleotides, and nucleic acids from the tissue sample may be captured using at least a subset of the single-stranded oligonucleotides.

Abstract: Described herein are systems and methods for analyzing biological samples (e.g., cells), including a method comprising (a) introducing a first cell into a fluidic device, (b) introducing a second cell into the fluidic device, (c) introducing a polymer precursor into the fluidic device, (d) using a virtual photomask to selectively apply light to the fluidic device to polymerize the polymer precursor, thereby selectively enclosing the first cell and the second cell in the fluidic device.

Abstract: Systems for analyzing biological components are provided. The systems may include a fluidic device and an energy source in communication with the fluidic device. The energy source may supply energy to the fluidic device to form a polymer matrix on or adjacent to a biological component within the fluidic device. Methods of using the systems to analyze biological components are also provided.

Abstract: Described herein are systems and methods for analyzing biological samples. The methods can include forming a compartment that at least partially encloses a cell. The methods can further include imaging the cell. The methods can also include analyzing a nucleic acid from the cell, for example by capturing the nucleic acid using a capture element, wherein the capture element is coupled to a surface of a fluidic device.

Abstract: Described herein are systems and methods for analyzing biological samples. The methods can include polymerizing a polymer precursor in the fluidic device, thereby forming a compartment comprising a polymer matrix wall. The compartment may enclose a cell within the fluidic device. The method may further include incubating the cell while the cell is within the compartment. The method may also include performing an assay within the compartment.

Abstract: Described herein are systems and methods for analyzing biological samples. The methods can include forming a plurality of compartments, wherein a compartment of the plurality of compartments may enclose a cell inside of a fluidic device. The methods can further include detecting an interaction between the cell and an additional cell within the fluidic device.

Abstract: Described herein are systems and methods for analyzing biological samples. Including a method for processing an analyte, comprising providing a fluidic device comprising the analyte and one or more polymer precursors; selecting a discrete area within said fluidic device; providing an energy source in optical communication with fluidic device; and selectively supplying a unit of energy generated from the energy source to the fluidic device to generate a polymer matrix within the fluidic device, wherein the polymer matrix is within the discrete area or adjacent to the discrete area.

Abstract: Described herein are systems and methods for analyzing biological samples. Including a method for processing an analyte, comprising providing a fluidic device comprising the analyte and one or more polymer precursors; selecting a discrete area within said fluidic device; providing an energy source in optical communication with fluidic device; and selectively supplying a unit of energy generated from the energy source to the fluidic device to generate a polymer matrix within the fluidic device, wherein the polymer matrix is within the discrete area or adjacent to the discrete area.

Abstract: Described herein are systems and methods for analyzing biological samples. Including a method for processing an analyte, comprising providing a fluidic device comprising the analyte and one or more polymer precursors; selecting a discrete area within said fluidic device; providing an energy source in optical communication with fluidic device; and selectively supplying a unit of energy generated from the energy source to the fluidic device to generate a polymer matrix within the fluidic device, wherein the polymer matrix is within the discrete area or adjacent to the discrete area.