Abstract: The present disclosure relates to a catechol group- or pyrogallol group-functionalized biocompatible polymer hydrogel patch having excellent biocompatibility and tissue adhesion, and uses for drug delivery, cell transplantation and tissue regeneration using the same. The biocompatible polymer hydrogel patch functionalized with the catechol group or pyrogallol group of the present disclosure has remarkably excellent mechanical properties and tissue adhesion compared with a solution-based bulk hydrogel. Therefore, it can load cells and a drug in vivo for a long time and also safely and efficiently deliver the cells and the drug to a target site.

Abstract: The present disclosure provides a microfluidic device for simulating a blood-brain barrier and a blood-brain barrier simulation system including the same, and the microfluidic device includes: a first channel; a second channel which is adjacently connected to the first channel through one or more microholes and configured to culture neural stem cells; and a chamber which is connected to both ends of the first channel and contains a culture medium.

Abstract: A scaffold composition that includes an organ extracellular matrix, wherein the organ is selected from the group consisting of intestine, stomach, liver, and lung. Preparing a scaffold composition may include decellularizing an isolated organ tissue to prepare a decellularized organ tissue; drying the decellularized organ tissue to prepare an organ extracellular matrix; and gelating the dried organ extracellular matrix. Culturing an organoid includes culturing an organoid in the scaffold composition.

Abstract: The present invention provides an organoid culture device, comprising at least one first chamber for storing a culture medium; at least one second chamber for culturing an organoid; and a channel that interconnects adjacent chambers.