Patents Assigned to CellCentric Limited
  • Patent number: 8658393
    Abstract: Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilizing a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: February 25, 2014
    Assignee: CellCentric Limited
    Inventors: Wolf Reik, Hugh Morgan, Chun-Fung Chan
  • Patent number: 8298529
    Abstract: Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilizing a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: October 30, 2012
    Assignee: CellCentric Limited
    Inventors: Wolf Reik, Hugh Morgan, Chun-Fung Chan
  • Publication number: 20110138491
    Abstract: Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilising a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.
    Type: Application
    Filed: April 10, 2007
    Publication date: June 9, 2011
    Applicant: CellCentric Limited
    Inventors: Wolf Reik, Hugh Morgan, Chun-Fung Chan