Abstract: Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
Type:
Grant
Filed:
May 5, 2009
Date of Patent:
January 29, 2013
Assignee:
Celldex Therapeutics Inc.
Inventors:
Tibor Keler, Lizhen He, Venky Ramakrishna, Laura A. Vitale
Abstract: The present invention provides isolated antibodies (e.g., humanized or human antibodies) that bind to the membrane-proximal domain (MP) of human Melanoma-Associated Chondroitin Sulphate Proteoglycan (MCSP), and are capable of mediating cytolysis of a cell expressing MCSP in the presence of human effector cells or complement. Methods of using such antibodies to induce cytolysis (e.g., ADCC or CDCC) of cells expressing MP-MCSP are also provided.
Type:
Grant
Filed:
September 10, 2007
Date of Patent:
November 27, 2012
Assignee:
Celldex Therapeutics Inc.
Inventors:
Tibor Keler, Laura A. Vitale, Lizhen He
Abstract: Oral immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing Escherichia coli (ETEC) and Vibrio cholerae based on the delivery of recombinant cholera toxin B antigen by attenuated, live bacterial vectors derived from Vibrio cholerae are disclosed. The compositions exhibit dual immunogenicity and retain the ability to colonize gastrointestinal mucosa-associated lymphoid tissues.
Type:
Grant
Filed:
April 24, 2008
Date of Patent:
October 16, 2012
Assignee:
Celldex Therapeutics, Inc.
Inventors:
Kevin P. Killeen, Kenneth L. Roland, Lawrence J. Thomas
Abstract: Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
Type:
Application
Filed:
October 19, 2011
Publication date:
August 23, 2012
Applicant:
CELLDEX THERAPEUTICS INC.
Inventors:
Tibor KELER, Henry C. MARSH, Lizhen HE, Laura A. VITALE, Lawrence J. THOMAS
Abstract: Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
Type:
Grant
Filed:
November 7, 2008
Date of Patent:
August 7, 2012
Assignee:
Celldex Therapeutics Inc.
Inventors:
Tibor Keler, Lizhen He, Venky Ramakrishna, Laura A. Vitale
Abstract: Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
Type:
Application
Filed:
April 13, 2011
Publication date:
November 10, 2011
Applicant:
CELLDEX THERAPEUTICS INC.
Inventors:
Tibor KELER, Henry C. MARSH, Lizhen HE, Laura A. VITALE, Lawrence J. THOMAS
Abstract: Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to Flt3-ligand as an isolated protein, the DNA encoding the Flt3-ligand, host cells transfected with cDNAs encoding Flt3-ligand, compositions comprising Flt3-ligand and methods of using Flt3-ligand in hematopoietic cell transplantation.
Abstract: The present invention provides isolated antibodies (e.g., humanized or human antibodies) that bind to the membrane-proximal domain (MP) of human Melanoma-Associated Chondroitin Sulphate Proteoglycan (MCSP), and are capable of mediating cytolysis of a cell expressing MCSP in the presence of human effector cells or complement. Methods of using such antibodies to induce cytolysis (e.g., ADCC or CDCC) of cells expressing MP-MCSP are also provided.
Type:
Application
Filed:
September 10, 2007
Publication date:
December 2, 2010
Applicant:
CELLDEX THERAPEUTICS INC.
Inventors:
Tibor Keler, Laura A. Vitale, Lizhen He
Abstract: Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
Type:
Application
Filed:
May 5, 2009
Publication date:
April 22, 2010
Applicant:
Celldex Therapeutics Inc.
Inventors:
Tibor Keler, Lizhen He, Venky Ramakrishna, Laura A. Vitale
Abstract: Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to dendritic cells are disclosed. Also disclosed are bispecifics, immunotoxins and antigen conjugates which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Type:
Grant
Filed:
May 8, 2001
Date of Patent:
July 21, 2009
Assignee:
CellDex Therapeutics, Inc.
Inventors:
Yashwant M. Deo, Tibor Keler, John Treml
Abstract: Cells transformed to express on their surface a component which binds to an Fc receptor of an effector cell are disclosed. Also disclosed are expression vectors used to transform the cells. Once transformed, the cells bind to effector cells via the Fc receptor of the effector cell to stimulate an effector cell mediated immune response.
Type:
Grant
Filed:
January 23, 2004
Date of Patent:
January 8, 2008
Assignee:
Celldex Therapeutics, Inc.
Inventors:
Tibor Keler, Joel Goldstein, Robert Graziano, Yashwant M. Deo
Abstract: The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (?hCG) antigen linked to an anti-mannose receptor (MR) antibody.
Type:
Application
Filed:
July 30, 2004
Publication date:
August 18, 2005
Applicant:
CELLDEX Therapeutics, Inc.
Inventors:
Tibor Keler, Michael Endres, Lizhen He, Venky Ramakrishna