Abstract: The present invention relates to preparation and use of nanocellulose fibrils or crystals such as disintegrated bacterial nanocellulose, tunicate-derived nanocellulose, or plant-derived nanocellulose, together with carbon nanotubes, as a biocompatible and conductive ink for 3D printing of electrically conductive patterns. Biocompatible conductive bioinks described in this invention were printed in the form of connected lines onto wet or dried nanocellulose films, bacterial cellulose membrane, or tunicate decellularized tissue. The devices were biocompatible and showed excellent mechanical properties and good electrical conductivity through printed lines (3.8·10?1 S cm?1). Such scaffolds were used to culture neural cells. Neural cells attached selectively on the printed pattern and formed connective networks.

Abstract: The present innovation relates to preparation and application of a robust, porous, three dimensional device for extra-hepatic delivery of human islets of Langerhans together with autologous stromal vascular fraction cells for treatment of patients with type 1 diabetes, and to a process of producing patient-specific devices using 3D Bioprinting with biocompatible hydrogel inks. More particularly, the present innovation uses 3D Bioprinting technology to produce a 3D device in which a patient's own adipose-derived stem cells will be able to improve the viability and efficacy of transplanted islets of Langerhans. Mesenchymal stem cells derived from the adipose tissue secrete components which provide a microenvironment for the islets that prevent cellular stress and result in improved viability of the islets.