Abstract: A skin-permeable peptide, a derivative thereof, or a fragment thereof of the present disclosure effectively delivers skin bioactive molecules deep into the skin tissues through assembly or fusion methods, thereby providing outstanding skin permeability as well as excellent skin residual effect of bioactive materials to maximize bioactive efficacy. Accordingly, the skin-permeable peptide, derivative thereof, or fragment thereof may be widely used as an active ingredient of a pharmaceutical composition for external use and a functional cosmetic composition that target skin tissues including mucous membranes.

Abstract: The tumor tissue-penetrating peptide of the present invention, a derivative thereof, or a fragment thereof effectively delivers a drug deep into tumor or tissues through an assembling or fusion method and exhibits not only excellent penetration activity into biomembranes but also excellent tumor selectivity to maximize anticancer activity, and thus the tumor tissue-penetrating peptide, a derivative thereof, or a fragment thereof can be widely utilized as an active ingredient in pharmaceutical compositions for treatment or prevention of and compositions for diagnosis of cancer or angiogenesis-related diseases, which exhibit improved tumor selectivity and delivery ability to tumor and target cancer tissues or cells including biomembranes.