Patents Assigned to CELLMATRIX
  • HUMANIZED COLLAGEN ANTIBODIES AND RELATED METHODS
    Publication number: 20100303726
    Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 2, 2010
    Applicant: CELLMATRIX
    Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
  • HUMANIZED COLLAGEN ANTIBODIES AND RELATED METHODS
    Publication number: 20080260733
    Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
    Type: Application
    Filed: May 8, 2008
    Publication date: October 23, 2008
    Applicant: CELLMATRIX
    Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks