Abstract: Described are methods of reducing pulmonary exacerbations and methods of treating cystic fibrosis, including methods of reducing pulmonary inflammation, comprising administration of an LTA4h inhibitor.
Type:
Grant
Filed:
January 11, 2021
Date of Patent:
February 6, 2024
Assignee:
Celltaxis, LLC
Inventors:
Sanjeev Ahuja, Ralph Grosswald, Gregory S. Duncan, Eric B. Springman
Abstract: The present invention is directed to methods of inhibiting LTA4-h in a human patient and method of treating a condition ameliorated by the inhibition of leukotriene A4 hydrolase activity in a human patient comprising administering to said human patient the compound, 4-{5-[4-(4-Oxazol-2-yl-phenoxy)-benzyl]-2,5-diaza-bicyclo[2.2.1]hept-2-ylmethyl}-benzoic acid.
Type:
Grant
Filed:
June 17, 2019
Date of Patent:
January 26, 2021
Assignee:
CELLTAXIS, LLC
Inventors:
Eric B. Springman, Margaret McCrann Pugh, Lopa Bhatt, Ralph Grosswald
Abstract: Described are methods of reducing pulmonary exacerbations and methods of treating cystic fibrosis, including methods of reducing pulmonary inflammation, comprising administration of an LTA4h inhibitor.
Type:
Grant
Filed:
May 31, 2019
Date of Patent:
January 26, 2021
Assignee:
CELLTAXIS, LLC
Inventors:
Sanjeev Ahuja, Ralph Grosswald, Gregory S. Duncan, Eric B. Springman