Abstract: Single enantiomer-threo-methylphenidate is useful in the therapy of a convulsant state, e.g. epilepsy, a bipolar disorder or narcolepsy. It may be administered topically.
Abstract: A process of treating a subject that is undergoing methylphenidate therapy and concomitant therapy with another drug undergoes or interferes with P450 metabolism, wherein the methylphenidate is d-threo-methylphenidate.
Type:
Grant
Filed:
October 21, 2002
Date of Patent:
September 11, 2007
Assignee:
Celltech Pharma Europe Limited
Inventors:
Andrew John McGlashan Richards, Nicholas Robert Pope
Abstract: The present invention pertains to a process for obtaining a single enantiomer, d or l, of threo-methylphenidate, comprising resolution of a mixture of the enantiomers; racemisation of the unwanted enantiomer, to give a mixture of all four stereoisomers; and separation of the erythro stereoisomers, to leave the same mixture of enantiomers for resolution.
Abstract: The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations were initially identified as being useful in vaccines from a bank of randomly inserted, transposon mutants in which attenuation was determined as a reduction in virulence of the organism in the mouse model of infection. Site directed mutation of the gene results in a strain which shows at least 4 logs of attenuation when delivered both orally and intravenously. Animals vaccinated with such a strain are protected against subsequent challenge with the parent wild type strain. Finally, heterologous antigens such as the non-toxic and protective, binding domain from tetanus toxin, fragment C, can be delivered via the mucosal immune system using such strains of bacteria. This results in the induction of a fully protective immune response to subsequent challenge with native tetanus toxin.
Type:
Grant
Filed:
June 9, 2000
Date of Patent:
June 14, 2005
Assignee:
Celltech Pharma Europe Limited
Inventors:
Steven Neville Chatfield, Gordon Dougan, Mark Sydenham