Abstract: Phenylalanine derivatives of formula (1) are described:
wherein
R is a carboxylic acid or a derivative thereof;
L1 is a linker atom or group;
and R5 is a group —L2(CH2)tR6 in which L2 is a —N(R7)CO— or —N(R7)CS— group.
The compounds are able to inhibit the binding &agr;4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
Type:
Grant
Filed:
May 20, 1999
Date of Patent:
March 26, 2002
Assignee:
Celltech Therapeutics, Ltd
Inventors:
John Clifford Head, Sarah Catherine Archibald, Graham John Warrellow, John Robert Porter