Abstract: In a method of creating a modified tissue graft, at least one exterior surface of a graft is modified by compressing, cutting and/or removing one or more portions thereof to create designed surface features which cause the tissue graft to have characteristics for a specific anatomical area. Medicants are associated with the surface features of the tissue graft, or with a second graft or layer which is associated with a base tissue graft. The tissue graft may be modified by pressing a specially configured template or die having blades thereon into the tissue graft to create a pattern of partial depth cuts.