Patents Assigned to Celltrion, Inc.
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Patent number: 11951207Abstract: The present invention provides a stable liquid pharmaceutical formulation containing: an antibody or its antigen-binding fragment; a surfactant; a sugar or its derivative; and a buffer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity while containing a high content of the antibody, has excellent long-term storage stability based on excellent stability under accelerated conditions and severe conditions, and may be administered subcutaneously.Type: GrantFiled: June 28, 2017Date of Patent: April 9, 2024Assignee: Celltrion Inc.Inventors: Joon Won Lee, Won Yong Han, Su Jung Kim, Jun Seok Oh, So Young Kim, Su Hyeon Hong, Yeon Kyeong Shin
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Publication number: 20240066110Abstract: The present invention relates to an immunogenic composition including multivalent pneumococcal polysaccharide-protein conjugates. Each conjugate includes capsular polysaccharides of different pneumococcus serotypes conjugated to a carrier protein. More concretely, the present invention is a multivalent immunogenic composition including polysaccharide-protein conjugates. Each of the polysaccharide-protein conjugates includes Streptococcus pneumoniae-derived capsular polysaccharides of different serotypes conjugated to a carrier protein. The capsular polysaccharides include a) capsular polysaccharides of one or more serotypes selected from the group consisting of serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F, and b) capsular polysaccharides of one or more serotypes selected from the group consisting of serotypes 10A, 11A, 12F, 15B, 22F, 23A, and 35B.Type: ApplicationFiled: January 13, 2022Publication date: February 29, 2024Applicant: CELLTRION INC.Inventors: Kyung Min Jo, Pan Kyeom Kim, Wan Geun La, Soo Young Lee, Jun Won Chwa, Ji Hyoun Cha
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Patent number: 11730698Abstract: A stable liquid pharmaceutical formulation according to the present invention includes an antibody or antigen-binding fragment thereof, a surfactant, a sugar or a sugar derivative, a buffer, and a stabilizer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity not only when antibody content is low but also when antibody content is high, and exhibits superior long-term storage stability based on superior stability observed under accelerated conditions and harsh conditions.Type: GrantFiled: July 18, 2019Date of Patent: August 22, 2023Assignee: CELLTRION INC.Inventors: So Young Kim, Yeon Kyeong Shin, Hye Young Kang, Kwang Woo Kim, Jun Seok Oh, Su Jung Kim, Joon Won Lee, Won Yong Han, Jae Bin Lee, Ji Won Roh, Ji Min Kwak
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Patent number: 11712407Abstract: The present invention relates to a hybrid-type multi-lamellar nanostructure of an epidermal growth factor and a liposome and a method for manufacturing same. The new type of hybrid-type multi-lamellar nanostructure not only has a high epidermal growth factor encapsulating efficiency, but also can be manufactured through a simple process, such that the same can be easily delivered into a living body or a cell while maintaining a high physiological activity of the epidermal growth factor.Type: GrantFiled: December 30, 2015Date of Patent: August 1, 2023Assignees: CELLTRION, INC., Korea Advanced institute of Science and TechnologyInventors: Yoon Sung Nam, Sung Duk Jo, Bon Il Koo
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Publication number: 20230088511Abstract: The present invention relates to a crystalline form of (?)-cibenzoline succinate. The present invention also provides a process for preparing (?)-cibenzoline succinate and a crystalline form thereof. The crystalline form of (?)-cibenzoline succinate according to the present invention has low hygroscopicity, and excellent stability under accelerated conditions and long-term storage conditions, and may be stably maintained without a change in content thereof for a long period of time.Type: ApplicationFiled: March 26, 2021Publication date: March 23, 2023Applicant: CELLTRION INC.Inventor: Sander Brugman
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Publication number: 20230040902Abstract: A pharmaceutical formulation including an immediate release layer and an extended release layer according to the present disclosure has a biphasic dissolution profile, such that it is possible to quickly reach an effective plasma concentration of cibenzoline at the early stage, and the effective plasma concentration may be continuously maintained at the late stage. Therefore, the medicinal effect of cibenzoline may be maintained only by an administration of a single formulation once a day.Type: ApplicationFiled: December 17, 2020Publication date: February 9, 2023Applicant: CELLTRION INC.Inventors: Kyung Suk Cho, GuK Bin Park, Jae Hun Song, Byung Kwan Moon, Hoon Namkoong, Ha Young Choi, Bon Joong Kim, Woo Hyong Cho, Da Wo Jeong, Soo Bin Jang
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Publication number: 20220177552Abstract: The present invention relates to a binding molecule having neutralizing activity against Middle East Respiratory Syndrome-Coronavirus (MERS-CoV). More particularly, the present invention relates to a binding molecule having strong ability to bind to an S protein of MERS-CoV and neutralizing activity against MERS-CoV and thus being very useful in the prevention, treatment or diagnosis of MERS-CoV infection.Type: ApplicationFiled: November 30, 2018Publication date: June 9, 2022Applicant: CELLTRION INC.Inventors: Soo Young Lee, Kye Sook Yi, Cheol Min Kim, Kyung Min Song, Yeon Jin Bae, Woo Joo Kim, Hee Jin Cheong, Joon Young Song, Man Seong Park, Ji Yun Noh
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Patent number: 11236146Abstract: Disclosed is a stable pharmaceutical formulation, comprising a fusion protein in which the extracellular ligand-binding domain of a human p75 tumor necrosis factor receptor is fused to the Fc domain of human IgG and a succinate buffering agent, without comprising a stabilizer. The stable pharmaceutical formulation enables the long-term storage of the TNFR-Fc fusion protein formulation and can exhibit superior storage stability without the need for demanding storage conditions, and is a simple formulation because no stabilizer is comprised therein and is thus more economical than other stabilizer-comprising formulations.Type: GrantFiled: October 26, 2017Date of Patent: February 1, 2022Assignee: Celltrion Inc.Inventors: Joon Won Lee, Won Yong Han, Su Jung Kim, Jun Seok Oh, So Young Kim, Kwang Woo Kim, Yeon Kyeong Shin
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Patent number: 11202751Abstract: The present invention relates to a cosmetic composition for whitening comprising a Caragana sinica root extract, and more specifically relates to a cosmetic composition having an outstanding skin-whitening effect, the composition comprising a Caragana sinica root extract, a fraction thereof or ?-viniferin isolated therefrom. In the present invention, the Caragana sinica root extract, fraction thereof or ?-viniferin isolated therefrom inhibits tyrosinase activity and suppresses melanin production and is therefore effective in skin whitening.Type: GrantFiled: June 29, 2016Date of Patent: December 21, 2021Assignees: CELLTRION INC., COSEEDBIOPHARM CO., LTD.Inventors: Sung Min Park, Jung No Lee, Hyo Min Kim, Jae Mun Kim, Kwang Jun Yoon, Seung Ki Lee, Jae Hun Kim, Yeon Sook Kim, Joo Hyuck Lim, Heyong Mi Kim, Sung Ho Moon
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Publication number: 20210315813Abstract: A stable liquid pharmaceutical formulation according to the present invention includes an antibody or antigen-binding fragment thereof, a surfactant, a sugar or a sugar derivative, a buffer, and a stabilizer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity not only when antibody content is low but also when antibody content is high, and exhibits superior long-term storage stability based on superior stability observed under accelerated conditions and harsh conditions.Type: ApplicationFiled: July 18, 2019Publication date: October 14, 2021Applicant: CELLTRION INC.Inventors: So Young Kim, Yeon Kyeong Shin, Hye Young Kang, Kwang Woo Kim, Jun Seok Oh, Su Jung Kim, Joon Won Lee, Won Yong Han, Jae Bin Lee, Ji Won Roh, Ji Min Kwak
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Publication number: 20210205454Abstract: Disclosed is a stable liquid formulation, comprising an antibody or antigen-binding portion thereof, an acetate buffer, glycine, and a surfactant, wherein the stable liquid formulation does not comprise at least one of sugar, a sugar alcohol and a metal salt, and the stable liquid formulation is still stable even upon high antibody content, and is superior in osmolality and viscosity, and subcutaneous administration thereof is possible.Type: ApplicationFiled: March 16, 2021Publication date: July 8, 2021Applicant: CELLTRION INC.Inventors: Joon Won LEE, Yeon Kyeong SHIN, Hye Young KANG, Kwang Woo KIM, So Young KIM, Su Jung KIM, Jun Seok OH, Won Yong HAN
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Patent number: 11007136Abstract: The present invention relates to a cosmetic composition for wrinkle reduction comprising, as an active ingredient, a Gynostemma pentaphyllum gypenoside fraction and, more specifically, to a cosmetic composition for wrinkle reduction, wherein the Gynostemma pentaphyllum gypenoside fraction includes at least one gypenoside selected from the group consisting of gypenoside UL1, gypenoside UL2, gypenoside UL3, gypenoside UL4, gypenoside UL5, gypenoside UL6, and gypenoside UL7.Type: GrantFiled: June 10, 2016Date of Patent: May 18, 2021Assignee: CELLTRION, INC.Inventors: Young Jun Park, Kee Won Yu, Jae Hun Kim, Yeon Sook Kim, Seung Ki Lee, Joo Hyuck Lim, Jong Mook Kim, Chi Ho Choi, Ju Yeon Kim, Jung Yun Kim, Sung Ho Moon
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Patent number: 10980881Abstract: Disclosed is a stable liquid formulation, comprising an antibody or antigen-binding portion thereof, an acetate buffer, glycine, and a surfactant, wherein the stable liquid formulation does not comprise at least one of sugar, a sugar alcohol and a metal salt, and the stable liquid formulation is still stable even upon high antibody content, and is superior in osmolality and viscosity, and subcutaneous administration thereof is possible.Type: GrantFiled: January 10, 2018Date of Patent: April 20, 2021Assignee: CELLTRION INC.Inventors: Joon Won Lee, Yeon Kyeong Shin, Hye Young Kang, Kwang Woo Kim, So Young Kim, Su Jung Kim, Jun Seok Oh, Won Yong Han
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Patent number: 10947497Abstract: The present invention relates to Nelumbo nucifera callus having an increased content of gallic acid or an extract thereof and to a method for preparing the same. The Nelumbo nucifera callus extract according to the present invention has an excellent whitening effect by containing a large amount of gallic acid, and thus can be advantageously used as a cosmetic composition.Type: GrantFiled: March 30, 2017Date of Patent: March 16, 2021Assignees: Celltrion Inc., BIO-FD&C Co., Ltd.Inventors: Yeon Sook Kim, Jung Yeon Kim, Jae Hun Kim, Hyeong Mi Kim, Jung Soo Bae, Jung Yun Kim, Ju Yeon Kim, Joo Hyuck Lim, Seung Ki Lee, Sung Ho Moon, Shin Jae Chang, Sang Hyun Moh, Jeong Hun Lee, Hyo Hyun Seo, Ji Hong Moh, Soo Yun Kim, Jeong Gon Park
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Publication number: 20200299721Abstract: The present invention relates to an expression cassette for a target protein, comprising a promoter, a polynucleotide coding for the target protein, an intron sequence, and a poly A sequence, an expression vector, and a transformant. The expression cassette for a target protein according to the present invention can simultaneously perform the expression of the intron sequence and the target protein through one transduction and exhibits the effect of inducing the high expression and high functionality of the target protein by regulating the expression of an endogenous gene.Type: ApplicationFiled: October 11, 2018Publication date: September 24, 2020Applicant: CELLTRION INC.Inventors: Man Su Kim, Min Soo Kim, Jong Moon Cho, Shin Jae Chang
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Patent number: 10722571Abstract: This invention relates to a rabies virus G protein epitope and a rabies-virus-neutralizing binding molecule that binds specifically thereto, wherein different epitope sites of rabies virus G protein are identified and binding molecules that bind thereto and a cocktail thereof can be found to retain neutralizing activity against various rabies viruses.Type: GrantFiled: June 9, 2016Date of Patent: July 28, 2020Assignee: Celltrion Inc.Inventors: Shin Jae Chang, Soo Young Lee, Pan Kyeom Kim, Jung Sun Ahn, Min Joo Choo
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Patent number: 10703802Abstract: The present invention provides a composition comprising at least two influenza A virus-neutralizing binding molecules that bind to an epitope in the stem region of influenza A virus hemagglutinin (HA) protein, the method comprising: i) a first binding molecule capable of neutralizing at least one influenza A virus subtype selected from the group consisting of H1, H2, H5 and H9; ii) a second binding molecule capable of neutralizing at least one influenza A virus subtype selected from the group consisting of H1, H3, H5, H7 and H9. The mixed composition of the present invention can effectively neutralize the multiple influenza subtypes of both phylogenetic group 1 and phylogenetic group 2 and can be used in combination with a chemical compound. Thus, the composition of the present invention is very useful for the prevention and treatment of a disease by influenza virus.Type: GrantFiled: March 28, 2014Date of Patent: July 7, 2020Assignee: CELLTRION, INC.Inventors: Seung Suh Hong, Shin Jae Chang, Ki Sung Kwon, Kye Sook Yi, Sung Hwan Kim, Eun Beom Lee, Jae Won Lee, So Jung Lee, Ji Young Shin, Myung Sam Cho
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Patent number: 10610587Abstract: This invention relates to an adjuvant composition containing at least one binding molecule for neutralizing influenza virus and a vaccine composition containing the same. The composition containing at least one binding molecule for neutralizing influenza virus is capable of increasing the effects of a vaccine, and can thus be used as an adjuvant, which increases an immune response upon vaccine administration, and is very useful in the prevention of diseases caused by viruses.Type: GrantFiled: September 13, 2018Date of Patent: April 7, 2020Assignee: CELLTRION INC.Inventors: Shin Jae Chang, Soo Young Lee, Byung Pil Lim, Pan Kyeom Kim, Sang Tae Park, Jung Sun Ahn, Eun Bee Park, Sun Ju Keum, Man Ki Song, Jung Ah Choi
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Patent number: 10507240Abstract: The present invention relates to an epitope specific to hepatitis B virus surface antigen and a binding molecule binding to the same for neutralizing hepatitis B virus. Since the epitope provided by the present invention is produced by forming a three-dimensional structure and does not comprise a determinant, by which escape mutation is induced against an administration of existing vaccines or HBIg, a composition comprising an antibody biding to the epitope or a vaccine composition comprising the epitope has a very low possibility of causing a decrease in efficacy due to escape mutation. Therefore, such an antibody or vaccine composition can be very effectively used in prevention and/or treatment of HBV.Type: GrantFiled: November 27, 2015Date of Patent: December 17, 2019Assignee: CELLTRION, Inc.Inventors: Joon Sun Yoon, Hwa Jin Lee, Kye Sook Yi, Cheol Min Kim, Byung Pil Lim, Shin Jae Chang, Seung Suh Hong
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Publication number: 20190343956Abstract: Disclosed is a stable liquid formulation, comprising an antibody or antigen-binding portion thereof, an acetate buffer, glycine, and a surfactant, wherein the stable liquid formulation does not comprise at least one of sugar, a sugar alcohol and a metal salt, and the stable liquid formulation is still stable even upon high antibody content, and is superior in osmolality and viscosity, and subcutaneous administration thereof is possible.Type: ApplicationFiled: January 10, 2018Publication date: November 14, 2019Applicant: CELLTRION INC.Inventors: Joon Won LEE, Yeon Kyeong SHIN, Hye Young KANG, Kwang Woo KIM, So Young KIM, Su Jung KIM, Jun Seok OH, Won Yong HAN