Patents Assigned to Cellular Engineering Technologies, Inc.
  • METHODS FOR CREATING INTEGRATION-FREE, VIRUS-FREE, EXOGENOUS ONCOGENE-FREE IPS CELLS AND COMPOSITIONS FOR USE IN SUCH METHODS
    Publication number: 20220235330
    Abstract: Methods are disclosed for reprogramming a somatic cell, including an adherent cell and a cell in suspension, into an induced pluripotent stem comprising expressing exogenous Sox-2, exogenous Klf-4, exogenous Oct3/4 from DNA that has not integrated into the genome of the somatic cell, suppressing p53 activity within the somatic cell, and exposing the somatic cell to reprogramming-assistance factors comprising an exogenous Alk-5 inhibitor, an exogenous histone deacetylase inhibitor, and an exogenous activator of glycolysis. Compositions and kits for use in such methods are also disclosed as are cells made by such a method.
    Type: Application
    Filed: February 2, 2022
    Publication date: July 28, 2022
    Applicant: Cellular Engineering Technologies, Inc.
    Inventors: Alan B. MOY, Anant KAMATH
  • Methods for creating integration-free, virus-free, exogenous oncogene-free IPS cells and compositions for use in such methods
    Patent number: 11268070
    Abstract: Methods are disclosed for reprogramming a somatic cell, including an adherent cell and a cell in suspension, into an induced pluripotent stem comprising expressing exogenous Sox-2, exogenous Klf-4, exogenous Oct3/4 from DNA that has not integrated into the genome of the somatic cell, suppressing p53 activity within the somatic cell, and exposing the somatic cell to reprogramming-assistance factors comprising an exogenous Alk-5 inhibitor, an exogenous histone deacetylase inhibitor, and an exogenous activator of glycolysis. Compositions and kits for use in such methods are also disclosed as are cells made by such a method.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: March 8, 2022
    Assignee: CELLULAR ENGINEERING TECHNOLOGIES, INC.
    Inventors: Alan B. Moy, Anant Kamath
  • METHODS FOR CREATING INTEGRATION-FREE, VIRUS-FREE, EXOGENOUS ONCOGENE-FREE IPS CELLS AND COMPOSITIONS FOR USE IN SUCH METHODS
    Publication number: 20190316095
    Abstract: Methods are disclosed for reprogramming a somatic cell, including an adherent cell and a cell in suspension, into an induced pluripotent stem comprising expressing exogenous Sox-2, exogenous Klf-4, exogenous Oct3/4 from DNA that has not integrated into the genome of the somatic cell, suppressing p53 activity within the somatic cell, and exposing the somatic cell to reprogramming-assistance factors comprising an exogenous Alk-5 inhibitor, an exogenous histone deacetylase inhibitor, and an exogenous activator of glycolysis. Compositions and kits for use in such methods are also disclosed as are cells made by such a method.
    Type: Application
    Filed: April 16, 2018
    Publication date: October 17, 2019
    Applicant: Cellular Engineering Technologies, Inc.
    Inventors: Alan B. MOY, Anant KAMATH