Abstract: The present disclosure relates to a pharmaceutical composition for inducing an exercise mimetic effect, which contains an ?1-adrenergic receptor agonist as an active ingredient, and a method for screening a drug for inducing an exercise mimetic effect using the ?1-adrenergic receptor agonist. The ?1-adrenergic receptor agonist of the present disclosure increases the expression of p-AMPK, PPAR? and PGC-1?, which play key roles in maintaining and regulating energy metabolic activity in vivo, thereby increasing glucose uptake into skeletal muscle cells, suppressing adipocyte differentiation and lipid accumulation, reducing abdominal fat and body weight as well as regulating mitochondrial metabolic disorders and suppressing inflammatory responses. Accordingly, the ?1-adrenergic receptor agonist can be usefully used to prevent and treat diseases requiring AMPK activation (metabolic diseases, cardiovascular diseases, inflammatory disease, etc.).

Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating diabetes and/or hyperlipidemia, which contains midodrine or a pharmaceutically acceptable salt thereof as an active ingredient, and to a use thereof.

Abstract: The present disclosure relates to a pharmaceutical composition for inducing an exercise mimetic effect, which contains an ?1-adrenergic receptor agonist as an active ingredient, and a method for screening a drug for inducing an exercise mimetic effect using the ?1-adrenergic receptor agonist. The ?1-adrenergic receptor agonist of the present disclosure increases the expression of p-AMPK, PPAR? and PGC-1?, which play key roles in maintaining and regulating energy metabolic activity in vivo, thereby increasing glucose uptake into skeletal muscle cells, suppressing adipocyte differentiation and lipid accumulation, reducing abdominal fat and body weight as well as regulating mitochondrial metabolic disorders and suppressing inflammatory responses. Accordingly, the ?1-adrenergic receptor agonist can be usefully used to prevent and treat diseases requiring AMPK activation (metabolic diseases, cardiovascular diseases, inflammatory disease, etc.).