Patents Assigned to Cellzome Limited
  • TRIAZOLOPYRIDINES AS TYK2 INHIBITORS
    Publication number: 20130143915
    Abstract: The present invention relates to compounds of Formula (I), wherein R1 to R6 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immuno logically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.
    Type: Application
    Filed: June 28, 2011
    Publication date: June 6, 2013
    Applicant: CELLZOME LIMITED
    Inventors: Katie Ellard, Nigel Ramsden
  • Piperidinyl and piperazinyl modulators of ?-secretase
    Patent number: 8252935
    Abstract: The present invention relates to compounds of Formula I as shown below, wherein the definitions of Het, R0, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with ?-secretase activity, including Alzheimer's disease.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: August 28, 2012
    Assignees: Janssen Pharmaceutica N.V., Cellzome Limited
    Inventors: Chih Yung Ho, Yan Zhang, Umar S. M. Maharoof, Jeremy Major, John Harrison
  • Amine linked modulators of ?-secretase
    Patent number: 8247610
    Abstract: The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, Y, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with ?-secretase activity, including Alzheimer's disease.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: August 21, 2012
    Assignees: Janssen Pharmaceutica N.V., Cellzome Limited
    Inventors: Chih Yung Ho, Yan Zhang, Umar S. M. Maharoof, John Harrison, Jeremy Major, Svenja Burckhardt, Alison Jones
  • SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS
    Publication number: 20120165332
    Abstract: The invention relates to compounds of formula (I) wherein R1 to R6 and T0 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: June 17, 2010
    Publication date: June 28, 2012
    Applicant: Cellzome Limited
    Inventors: Jeremy Major, Nelly Piton
  • (Biphenyl) carboxylic acids and derivatives thereof
    Patent number: 7825160
    Abstract: The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of ?-secretase activity.
    Type: Grant
    Filed: October 21, 2005
    Date of Patent: November 2, 2010
    Assignee: Cellzome Limited
    Inventors: Francis Wilson, Alison Reid, Valerie Reader, Richard John Harrison, Mihiro Sunose, Remedios Hernandez-Perni, Jeremy Major, Cyrille Boussard, Kathryn Smelt, Jess Taylor, Adeline Leformal, Andrew Cansfield, Svenja Burckhardt
  • TRIAZOLE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20100227800
    Abstract: The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
    Type: Application
    Filed: August 30, 2007
    Publication date: September 9, 2010
    Applicant: CELLZOME LIMITED
    Inventors: Francis Wilson, Nigel Ramsden, Kathryn Bell, Andrew Cansfield, Svenja Burckhardt, Jess Taylor, Mihiro Sunose, David Middlemiss