Abstract: The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
Type:
Grant
Filed:
August 30, 2007
Date of Patent:
November 11, 2014
Assignee:
Cellzome Ltd.
Inventors:
Francis Wilson, Nigel Ramsden, Kathryn Bell, Andrew Cansfield, Svenja Burckhardt, Jess Taylor, Mihiro Sunose, David Middlemiss
Abstract: The invention relates to compounds of formula (I) wherein X, T1 and R1 to R3 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of PI3K, for the treatment or prophylaxis of immunological, inflammatory, autoimmune, or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
Type:
Grant
Filed:
November 21, 2008
Date of Patent:
October 21, 2014
Assignee:
Cellzome Ltd.
Inventors:
Nigel Ramsden, Kathryn Bell, Andrew David Cansfield, Jess Taylor, Mihiro Sunose, David Middlemiss, Gitte Neubauer