Patents Assigned to CeloNova BioSciences, Inc.
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Patent number: 10881540Abstract: An implantable stent includes multiple circumferential segments that surround a bore and are connected in series along a length to form a tubular wall. Multiple adjacent alternating opposite facing crowns arranged along each segment's circumference are bridged by struts. The struts include a series of staggered arcuate edges with limited flats to provide a limited region of maximum width between significantly extended reducing diameter tapers at either end where they transition into the crowns. Connections between adjacent segments are wider and stiffer than the struts and strut-crown transitions in the segments. The crowns include inner and outer radii with off-set centers along a common axis to provide medial crown peaks along the axis that are wider than the narrowed crown shoulders on either side of the axis and from which the tapered struts extend. Material strain and flexure along the stent during lateral bending is distributed mainly within the segments, e.g.Type: GrantFiled: May 3, 2019Date of Patent: January 5, 2021Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Michael J. Lee, Stuart Earl Kari, Riley King
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Publication number: 20190254847Abstract: An implantable stent includes multiple circumferential segments that surround a bore and are connected in series along a length to form a tubular wall. Multiple adjacent alternating opposite facing crowns arranged along each segment's circumference are bridged by struts. The struts include a series of staggered arcuate edges with limited flats to provide a limited region of maximum width between significantly extended reducing diameter tapers at either end where they transition into the crowns. Connections between adjacent segments are wider and stiffer than the struts and strut-crown transitions in the segments. The crowns include inner and outer radii with off-set centers along a common axis to provide medial crown peaks along the axis that are wider than the narrowed crown shoulders on either side of the axis and from which the tapered struts extend. Material strain and flexure along the stent during lateral bending is distributed mainly within the segments, e.g.Type: ApplicationFiled: May 3, 2019Publication date: August 22, 2019Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Michael J. LEE, Stuart Earl KARI, Riley KING
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Patent number: 10327926Abstract: There is disclosed an implantable medical stent system, including: a radially expandable stent comprising a filamental structure in a pattern surrounding a bore to form a substantially tubular wall along a length relative to a longitudinal axis; in which the filamental structure includes at least one arcuate crown with a crown peak having a radius of curvature located along a reference axis, and first and second arcuate crown shoulders on first and second sides, respectively, of the reference axis; in which the filamental structure also includes at least one pair of first and second elongated struts extending from the first and second crown shoulders, respectively; the first and second elongated struts have a region of constant maximum width at an intermediate portion and tapering toward the first and second crown shoulders.Type: GrantFiled: August 11, 2016Date of Patent: June 25, 2019Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Michael J. Lee, Stuart Earl Karl, Riley King
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Patent number: 10285968Abstract: The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which elute once deployed in a patient and can have anti-proliferative, anti-inflammation, or anti-thrombotic effects. Sol gel technology can be used to coat the devices.Type: GrantFiled: March 13, 2018Date of Patent: May 14, 2019Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Richard Klein, John Birtles, John Koos, Michael J. Lee
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Publication number: 20180200222Abstract: The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which elute once deployed in a patient and can have anti-proliferative, anti-inflammation, or anti-thrombotic effects. Sol gel technology can be used to coat the devices.Type: ApplicationFiled: March 13, 2018Publication date: July 19, 2018Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Richard KLEIN, John BIRTLES, John KOOS, Michael J. LEE
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Patent number: 9949944Abstract: The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which elute once deployed in a patient and can have anti-proliferative, anti-inflammation, or anti-thrombotic effects. Sol gel technology can be used to coat the devices.Type: GrantFiled: July 17, 2015Date of Patent: April 24, 2018Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Richard Klein, John Birtles, John Koos, Michael J. Lee
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Patent number: 9717608Abstract: An expandable, bistable open cell design incorporates the following features: a first relatively stiff portion (152) having first and second ends and a first relatively flexible portion (154) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a first open area (156) of the stent structure; a second relatively stiff portion (158) having first and second ends and a second relatively flexible portion (160) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a second open area (162) of the stent structure; and an opening (110) formed through the first relatively stiff portion and the second relatively flexible portion such that the opening connects the first and second open areas, thereby creating first and second intermediate ends (152a, 152b) of the first rType: GrantFiled: May 2, 2016Date of Patent: August 1, 2017Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Andy Edward Denison, Mark C. Bates, Kent C. B. Stalker
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Patent number: 9445927Abstract: An implantable medical stent system, including a radially expandable stent including a filamental structure in a pattern surrounding a bore to form a substantially tubular wall along a length relative to a longitudinal axis; wherein the filamental structure includes at least one actuate crown with a crown peak having a radius of curvature located along a reference axis, and first and second arcuate crown shoulders on first and second sides, respectively, of the reference axis; and wherein the filamental structure also includes at least one pair of adjacent first and second elongated struts extending from the first and second crown shoulders, respectively.Type: GrantFiled: September 6, 2011Date of Patent: September 20, 2016Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Michael J. Lee, Stuart Earl Kari, Riley King
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Publication number: 20160250046Abstract: An expandable, bistable open cell design incorporates the following features: a first relatively stiff portion (152) having first and second ends and a first relatively flexible portion (154) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a first open area (156) of the stent structure; a second relatively stiff portion (158) having first and second ends and a second relatively flexible portion (160) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a second open area (162) of the stent structure; and an opening (110) formed through the first relatively stiff portion and the second relatively flexible portion such that the opening connects the first and second open areas, thereby creating first and second intermediate ends (152a, 152b) of the first rType: ApplicationFiled: May 2, 2016Publication date: September 1, 2016Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Andy Edward DENISON, Mark C. BATES, Kent C.B. STALKER
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Patent number: 9358139Abstract: An expandable, bistable open cell design incorporates the following features: a first relatively stiff portion (152) having first and second ends and a first relatively flexible portion (154) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a first open area (156) of the stent structure; a second relatively stiff portion (158) having first and second ends and a second relatively flexible portion (160) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a second open area (162) of the stent structure; and an opening (110) formed through the first relatively stiff portion and the second relatively flexible portion such that the opening connects the first and second open areas, thereby creating first and second intermediate ends (152a, 152b) of the first rType: GrantFiled: August 30, 2011Date of Patent: June 7, 2016Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Andy Edward Denison, Kent C. B. Stalker, Mark Bates
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Patent number: 9114125Abstract: The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which elute once deployed in a patient and can have anti-proliferative, anti-inflammation, or anti-thrombotic effects. Sol gel technology can be used to coat the devices.Type: GrantFiled: April 11, 2008Date of Patent: August 25, 2015Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Richard Klein, John Birtles, John Koos, Michael J. Lee
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Patent number: 9114162Abstract: Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Microspheres of the present invention may further be provided with physical and/or chemical enhancements within the particles' cores to enhance visualization of the embolized tissue using a variety of medical imaging modalities, including conventional radiography, fluoroscopy, tomography, computerized tomography, ultrasound, scintillation, magnetic resonance, or other imaging technologies.Type: GrantFiled: October 24, 2007Date of Patent: August 25, 2015Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Jacques Blümmel, Alexander Küller, Gretchen B. Wojcik
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Patent number: 9107850Abstract: Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.Type: GrantFiled: October 26, 2007Date of Patent: August 18, 2015Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Jacques Blümmel, Alexander Küller, Gretchen B. Wojcik
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Patent number: 9080146Abstract: This disclosure relates to substrates containing at least one polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The disclosure also relates to a method for producing such substrates and substrates containing polyphosphazene with a micro-structured surface.Type: GrantFiled: September 25, 2008Date of Patent: July 14, 2015Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Michael Grunze, Ulf Fritz
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Publication number: 20140012364Abstract: An expandable, bistable open cell design incorporates the following features: a first relatively stiff portion (152) having first and second ends and a first relatively flexible portion (154) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a first open area (156) of the stent structure; a second relatively stiff portion (158) having first and second ends and a second relatively flexible portion (160) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a second open area (162) of the stent structure; and an opening (1 10) formed through the first relatively stiff portion and the second relatively flexible portion such that the opening connects the first and second open areas, thereby creating first and second intermediate ends (152a, 152b) of the firstType: ApplicationFiled: August 30, 2011Publication date: January 9, 2014Applicant: CeloNova BioSciences, IncInventors: Andy Edward Denison, Kent Stalker, Mark Bates
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Publication number: 20130309290Abstract: A stent is provided in combination with delivery of a tocopherol agent, and in particular a des-methyl tocopherol agent, and further beneficially a gamma-tocopherol agent, so as to reduce restenosis along the vessel or other lumenal wall where the stent is implanted. In particular applications, the stent is an endolumenal stent, and more specific beneficial applications is an endovascular stent, and the gamma-tocopherol elutes from a coating or carrier coupled with the stent. Certain combinations are provided with the des-methyl-tocopherol or phytyl substituted chromanol, e.g. gamma-tocopherol, combined with an additional agent such as an anti-restenosis agent, e.g. sirolimus, tacrolimus, everolimus, or paclitaxel, in order to provide synergistic benefit to tissues along the stented or recanalized regions. Other forms of tocopherol or tocotrienol, or other phytyl substituted chromanols, and other compounds such as palm oil, are ailso contemplated. for use to treat restenosis.Type: ApplicationFiled: July 29, 2013Publication date: November 21, 2013Applicant: CeloNova BioSciences, Inc.Inventors: James W. Larrick, James C. Peacock, III
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Patent number: 8541014Abstract: The present invention is directed to a drug eluting stent system, including: a stent; a tocopherol agent coupled to the stent; wherein the stent is adapted to elute the tocopherol agent into a surrounding lumenal wall tissue when implanted along the lumen within a body of a patient.Type: GrantFiled: January 24, 2012Date of Patent: September 24, 2013Assignee: CeloNova BioSciences, Inc.Inventors: James W. Larrick, James C. Peacock, III
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Publication number: 20120323310Abstract: The present invention is directed to a drug eluting stent system, including: a stent; a tocopherol agent coupled to the stent; wherein the stent is adapted to elute the tocopherol agent into a surrounding lumenal wall tissue when implanted along the lumen within a body of a patient.Type: ApplicationFiled: January 24, 2012Publication date: December 20, 2012Applicant: CELONOVA BIOSCIENCES, INC.Inventors: James W. Larrick, James C. Peacock, III
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Publication number: 20120183782Abstract: The present disclosure relates to implants with a biocompatible coating having antithrombogenic properties and which also contains a pharmacologically active agent, as well as a process for their production.Type: ApplicationFiled: August 17, 2011Publication date: July 19, 2012Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Olaf Fritz, Ulf Fritz, Stefan Nagel, Michael Boxberger
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Patent number: 8101199Abstract: A stent is provided in combination with delivery of a tocopherol agent, and in particular a des-methyl tocopherol agent, and further beneficially a gamma-tocopherol agent, so as to reduce restenosis along the vessel or other lumenal wall where the stent is implanted. In particular applications, the stent is an endolumenal stent, and more specific beneficial applications is an endovascular stent, and the gamma-tocopherol elutes from a coating or carrier coupled with the stent. Certain combinations are provided with the des-methyl-tocopherol or phytyl substituted chromanol, e.g. gamma-tocopherol, combined with an additional agent such as an anti-restenosis agent, e.g. sirolimus, tacrolimus, everolimus, or paclitaxel, in order to provide synergistic benefit to tissues along the stented or recanalized regions. Other forms of tocopherol or tocotrienol, or other phytyl substituted chromanols, and other compounds such as palm oil, are also contemplated, for use to treat restenosis.Type: GrantFiled: October 21, 2004Date of Patent: January 24, 2012Assignee: Celonova Biosciences, Inc.Inventors: James W. Larrick, James C. Peacock, III