Patents Assigned to Celula, Inc.
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Patent number: 9051602Abstract: Disclosed are methods and genotyping panels for detecting alleles, genomes, and transcriptomes in admixtures of two individuals.Type: GrantFiled: December 22, 2009Date of Patent: June 9, 2015Assignee: Celula, Inc.Inventors: Arnold R. Oliphant, Kurt A. Krummel, Haichuan Zhang, Andrew S. Katz
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Publication number: 20150064695Abstract: The present invention relates to methods and systems useful for screening and/or diagnosing genetic conditions in a fetus.Type: ApplicationFiled: December 16, 2011Publication date: March 5, 2015Applicant: Celula Inc.Inventors: Andrew S Katz, Andrew E Senyei
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Publication number: 20140371083Abstract: Systems, apparatus and methods are provided for biochemical analysis of a sample (e.g., a cell or nucleic acids). Samples are analyzed for molecular information and remain accessible for subsequent analysis or testing. The systems, apparatus and methods and systems provided are useful for performing quantitative and highly parallel biochemical reactions on biological samples in a high-throughput manner.Type: ApplicationFiled: July 13, 2012Publication date: December 18, 2014Applicant: CELULA, INC.Inventors: Keunho Ahn, Benjamin Lai, Andree J. Pyfer, Yi Zhang, Haichuan Zhang
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Publication number: 20140295419Abstract: Disclosed are methods and compositions for amplification of genetic material, including isothermal WGA of single cells.Type: ApplicationFiled: May 4, 2012Publication date: October 2, 2014Applicant: CELULA, INC.Inventors: Haichuan Zhang, Zuxu Yao, Kerry Gunning
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Patent number: 8691164Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. Optical and/or fluidic switching forces are used alone or in combination to effect switching.Type: GrantFiled: July 23, 2007Date of Patent: April 8, 2014Assignee: Celula, Inc.Inventors: William Frank Butler, Haichuan Zhang, Philippe Marchand, Keunho Ahn, Yi Zhang, John Francis, Benjamin Lai, Eugene Tu
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Patent number: 8426209Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.Type: GrantFiled: June 28, 2010Date of Patent: April 23, 2013Assignee: Celula, Inc.Inventors: William Frank Butler, Mirianas Chachisvilis, Robert Dees, Norbert Hagen, Philippe Marchand, Daniel E. Raymond, Eugene Tu, Mark M. Wang, Joon Mo Yang, Rong Yang, Haichuan Zhang
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Publication number: 20120077191Abstract: Described herein are compositions and methods useful for the detection of nucleic acid variations. Ligation within a probe or between probes is used to distinguish between probes perfectly complementary to a target and those containing a mismatch. Nucleotide fill-in/extension steps are optionally applied according to the type of assay performed. A circularization and relinearization step can be applied to create a template for further amplification and detection. In certain aspects, portions of a target sequence or its complement are not amplified.Type: ApplicationFiled: August 11, 2011Publication date: March 29, 2012Applicant: CELULA, INC.Inventors: KERRY GUNNING, KURT A. KRUMMEL, RUSSEL BALDOCCHI, YI ZHANG, RAMA GHATTI, HAICHUAN ZHANG, EUGENE TU, ANDREW S. KATZ
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Publication number: 20110086769Abstract: Disclosed are methods and genotyping panels for detecting alleles, genomes, and transcriptomes in admixtures of two individuals.Type: ApplicationFiled: December 22, 2009Publication date: April 14, 2011Applicant: Celula, Inc.Inventors: Arnold R. Oliphant, Kurt A. Krummel, Haichuan Zhang, Andrew S. Katz
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Publication number: 20110039258Abstract: Disclosed is a method and compositions for the differential expansion of fetal cells over maternal cells. In the method, cells from a sample of maternal blood containing CD34+ cells of both maternal and fetal origin are incubated in the presence of Stem Cell Factor in serum free media. It has been discovered that incubation of fetal cells in the presence of SCF will preferentially expand the fetal cells relative to adult cells. Fetal cells can also be identified, enriched or obtained by differential expansion of the fetal cells during colony formation. It has been discovered that differential expansion of fetal cells can result in colonies of fetal cells that are larger than colonies of adult cells. The fetal CD34+ cells can be expanded without generation of significant clonal genetic artifacts during expansion. Also disclosed is a method and compositions for producing differentiated fetal cells.Type: ApplicationFiled: October 15, 2007Publication date: February 17, 2011Applicant: CELULA INC.Inventors: Patricia McNeeley, Philippe Marchand, Jonathan Diver
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Patent number: 7745221Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.Type: GrantFiled: August 27, 2004Date of Patent: June 29, 2010Assignee: Celula, Inc.Inventors: William Frank Butler, Mirianas Chachisvilis, Robert Dees, Norbert Hagen, Philippe Marchand, Daniel E. Raymond, Eugene Tu, Mark M. Wang, Joon Mo Yang, Rong Yang, Haichuan Zhang