Patents Assigned to Celularity, Inc.
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Publication number: 20190152676Abstract: Provided herein are devices and methods for thawing frozen biological material.Type: ApplicationFiled: June 18, 2018Publication date: May 23, 2019Applicant: CELULARITY, INC.Inventor: Brian Murphy
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Publication number: 20190117705Abstract: Provided herein are compositions comprising mononuclear cells from human placental perfusate and methods of using such cells, including using the cells together with hematopoietic cells, for example to establish chimerism, reduce the severity or duration of graft versus host disease, treat or ameliorate symptoms of sarcopenia, metabolic disorders and hematologic disorders, such as hematologic malignancies, and treat or ameliorate symptoms of ischemic encephalopathy (e.g., hypoxic ischemic encephalopathy) and other central nervous system injuries.Type: ApplicationFiled: November 23, 2018Publication date: April 25, 2019Applicant: CELULARITY, INC.Inventors: Jodi P. Gurney, Xiaokui Zhang, Stacy Herb, Robert J. Hariri
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Publication number: 20190093081Abstract: Provided provided herein are methods of treating a subject having a brain tumor, e.g., a glioblastoma by administering to the subject an effective amount of a cell population comprising human placenta-derived natural killer cells. Also provided are methods of suppressing the growth of brain tumor cells comprising contacting the glioblastoma cells with an effective amount of a cell population comprising human placenta-derived natural killer cells. Further provided are compositions comprising subject an effective amount of a cell population comprising human placenta-derived natural killer cells for use in the treatment of a brain tumor in a subject or for use in the manufacture of a medicament for treatment of a brain tumor in a subject.Type: ApplicationFiled: September 28, 2018Publication date: March 28, 2019Applicant: CELULARITY, INC.Inventors: Lin KANG, Xiaokui ZHANG, William VAN DER TOUW, Robert J. HARIRI, Shuyang HE
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Publication number: 20190089124Abstract: The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.Type: ApplicationFiled: March 14, 2018Publication date: March 21, 2019Applicant: CELULARITY, INC.Inventors: Mohit B. Bhatia, Chris Lugo, Qian Ye, James W. Edinger
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Patent number: 10179152Abstract: Provided herein are methods of treatment comprising administering to a subject, e.g., a human subject, mononuclear cells from human placental perfusate and hematopoietic cells, and compositions comprising them, and their uses to establish chimerism, engraft tissue (e.g., blood), reduce the severity or duration of graft versus host disease, and treat or ameliorate symptoms of metabolic disorders and hematologic disorders, such as hematologic malignancies.Type: GrantFiled: October 2, 2014Date of Patent: January 15, 2019Assignee: Celularity, Inc.Inventors: Jodi P. Gurney, Xiaokui Zhang, Stacy Herb, Robert J. Hariri
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Publication number: 20180346877Abstract: Provided herein are methods of producing natural killer (NK) cells and/or ILC3 cells using a three-stage expansion and differentiation method with media comprising stem cell mobilizing factors. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein to an individual having the cancer or viral infection.Type: ApplicationFiled: October 14, 2016Publication date: December 6, 2018Applicant: CELULARITY, INC.Inventors: Xiaokui ZHANG, Ivana DJURETIC, Lin KANG, Vanessa VOSKINARIAN-BERSE, Bhavani STOUT, Robert J. HARIRI, Wolfgang HOFGARTNER, James EDINGER, Eric LAW, Vladimir JANKOVIC
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Patent number: 10113146Abstract: A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom.Type: GrantFiled: June 9, 2016Date of Patent: October 30, 2018Assignee: CELULARITY, INC.Inventor: Robert J. Hariri
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Patent number: 10104880Abstract: Provided herein are improved methods for the formulation of compositions comprising placental stem cells, and improved compositions and cell formulations produced thereby.Type: GrantFiled: August 20, 2009Date of Patent: October 23, 2018Assignee: CELULARITY, INC.Inventors: Andy Zeitlin, Gregory Russotti, Shuyang He, Ajai Pal, Hong J. Chen, Thomas Brieva, Ryan Shorr, Brian Murphy
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Patent number: 10105399Abstract: Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.Type: GrantFiled: April 7, 2016Date of Patent: October 23, 2018Assignee: CELULARITY, INC.Inventors: James W. Edinger, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Kristen S. Labazzo, Marian Pereira, Sascha Dawn Abramson
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Publication number: 20180298328Abstract: Provided herein are stimulated placental stem cells and methods of treating individuals having diseases or disorders of the circulatory system using stimulated placental cells. The invention also provides methods of inducing angiogenesis using such stimulated cells or populations of cells comprising such stimulated cells.Type: ApplicationFiled: May 25, 2016Publication date: October 18, 2018Applicant: Celularity, Inc.Inventors: Kathy E. KARASIEWICZ-MENDEZ, Aleksandar FRANCKI, Jeffrey TURNER, Eric LAW, Jennifer PAREDES, Kristen LABAZZO, Hemlata RANA, Wolfgang HOFGARTNER, Robert J. HARIRI
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Publication number: 20180284142Abstract: Provided herein are methods for assessing cell potency.Type: ApplicationFiled: September 28, 2016Publication date: October 4, 2018Applicant: CELULARITY, INC.Inventors: Gregory RUSSOTTI, Jaymes FULLER, Christopher WIWI
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Publication number: 20180273903Abstract: Provided herein are genetically modified (GM) natural killer (NK) cells and methods of producing populations of GM NK cells. Further provided herein are methods of using the GM NK cells described herein, to, e.g., suppress the proliferation of tumor cells, or to inhibit pathogen infection, e.g., viral infection. In certain alternatives, GM NK cells provided herein lack expression of CBLB, NKG2A and/or TGFBR2 and/or function or show reduced expression and/or function of CBLB, NKG2A and/or TGFBR2. In certain alternatives, GM NK cells provided herein comprise modified CD16.Type: ApplicationFiled: December 28, 2017Publication date: September 27, 2018Applicant: Celularity, Inc.Inventors: Xiaokui Zhang, Qian Ye, Tianjian Li, Chuan Wang, Mini Bharathan, Uri Herzberg
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Publication number: 20180264048Abstract: Provided herein are methods of using CD10+, CD34?, CD105+, CD200+ tissue culture plastic-adherent placental cells, e.g. placental stem cells, in the treatment of diabetic peripheral neuropathy (DPN).Type: ApplicationFiled: September 14, 2016Publication date: September 20, 2018Applicant: CELULARITY, INC.Inventors: Steven A. FISCHKOFF, Denesh CHITKARA
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Publication number: 20180237744Abstract: The present invention provides methods for culturing, expanding and differentiating stem cells, particularly human embryonic stem cells. The methods comprise culturing the stem cells for a period of time on a collagen biofabric, particularly a collagen biofabric derived from the amniotic membrane, chorion, or both, from mammalian placenta.Type: ApplicationFiled: September 27, 2017Publication date: August 23, 2018Applicant: CELULARITY INC.Inventor: Mohammad Heidaran
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Publication number: 20180233218Abstract: Methods, computer systems, and computer program products for maintaining a stem cell registry comprising information about a plurality of stem cell units. A donor is enrolled in the stem cell registry. A stem cell unit from the donor is characterized. Information about the stem cell unit, obtained by the characterizing, is recorded in the stem cell registry. Computer readable media comprising a plurality of data records. One or more respective data records in the plurality of data records comprises (i) a collection identifier number that uniquely corresponds to a stem cell donation, (ii) a cord blood cell count associated with the stem cell donation, and (iii) a placenta blood cell count associated with the stem cell donation. Additional computer readable media comprising a plurality of data records.Type: ApplicationFiled: April 17, 2018Publication date: August 16, 2018Applicant: CELULARITY, INC.Inventors: Joseph K. KAMINSKI, Mark H. DEIBERT, Chris B. GOODMAN, Barnett FEINGOLD
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Patent number: 10041043Abstract: Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perforate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrate erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place.Type: GrantFiled: December 22, 2015Date of Patent: August 7, 2018Assignee: CELULARITY, INC.Inventors: Stewart Abbot, Lin Kang, Vanessa Voskinarian-Berse, Xiaokui Zhang
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Patent number: 9974840Abstract: The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.Type: GrantFiled: September 11, 2013Date of Patent: May 22, 2018Assignee: Celularity, Inc.Inventors: Mohit Bhatia, Chris Lugo, Qian Ye, James W. Edinger
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Patent number: 9925221Abstract: Provided herein are methods of treatment of an individual having amyotrophic lateral sclerosis, comprising administering to the individual a therapeutically effective amount of placental stem cells, e.g., tissue culture surface-adherent placental stem cells (PDACs). In one aspect, provided herein is a method of treating amyotrophic lateral sclerosis (ALS) comprising administering to an individual having ALS a therapeutically effective amount of placental stem cells. In certain embodiments, “therapeutically effective” means an amount effective to reduce or ameliorate one or more symptoms of ALS.Type: GrantFiled: September 10, 2012Date of Patent: March 27, 2018Assignee: Celularity, Inc.Inventors: Robert J. Hariri, Jodi P. Gurney
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Publication number: 20180071343Abstract: Provided herein are methods of treating individuals having diseases or disorders of the circulatory system, using placental cells, e.g., the placental stem cells and placental multipotent cells (PDACs) described herein, and populations of such placental cells. The invention also provides methods of angiogenesis using such cells or populations of cells comprising such cells.Type: ApplicationFiled: November 16, 2017Publication date: March 15, 2018Applicant: Celularity, Inc.Inventors: Stewart Abbot, James Edinger, Aleksander Francki, Robert J. Hariri, Vladimir Jankovic, Aleksandr Kaplunovsky, Kristen Labazzo, Eric Law, Neerav Padliya, Jennifer Paredes, Jia-Lun Wang
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Patent number: 9775886Abstract: The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.Type: GrantFiled: September 11, 2012Date of Patent: October 3, 2017Assignee: Celularity, Inc.Inventors: Mohit Bhatia, Chris Lugo, Qian Ye, James W. Edinger