Patents Assigned to Cenetron Diagnostics LLC
  • METHODS AND COMPOSITIONS COMPRISING NUCLEIC ACID POLYMERIZATION ENHANCERS
    Publication number: 20110282043
    Abstract: Embodiments of the invention are directed to compositions and methods that use non-extendable oligonucleotides to enhance or improve synthesis or amplification of nucleic acids.
    Type: Application
    Filed: March 11, 2011
    Publication date: November 17, 2011
    Applicant: Cenetron Diagnostics LLC
    Inventor: Dwight Dubois
  • Ribonuclease resistant RNA preparation and utilization
    Patent number: 7033749
    Abstract: The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: April 25, 2006
    Assignees: Ambion, Inc., Cenetron Diagnostics LLC
    Inventors: Brittan L. Pasloske, Dwight B. DuBois, David M. Brown, Matthew M. Winkler
  • Methods of quantifying viral load in an animal with a ribonuclease resistant RNA preparation
    Patent number: 6399307
    Abstract: The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: June 4, 2002
    Assignees: Ambion, Inc., Cenetron Diagnostics, LLC
    Inventors: Brittan L. Pasloske, Dwight B. DuBois, David M. Brown, Matthew M. Winkler
  • Method for monitoring nucleic acid assays using synthetic internal controls with reversed nucleotide sequences
    Patent number: 6395470
    Abstract: The present invention relates to methods and compositions that provide a positive control to identify inhibition during a signal amplification reaction. The methods and compositions of the present invention are designed to run in the same tube or assay environment as the experimental or target sample and contain a copy of the target sequence in an inverted form.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: May 28, 2002
    Assignee: Cenetron Diagnostics, LLC
    Inventors: Cindy R. WalkerPeach, Dwight B. Dubois
  • Ribonuclease resistant RNA preparation and utilization
    Patent number: 5939262
    Abstract: The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: August 17, 1999
    Assignees: Ambion, Inc., Cenetron Diagnostics, LLC
    Inventors: Brittan L. Pasloske, Dwight DuBois, David Brown, Matthew Winkler
  • Ribonuclease resistant viral RNA standards
    Patent number: 5919625
    Abstract: The present invention is directed to the process of creating a recombinant nucleic acid standard which is resistant to ribonuclease digestion and is non-infectious. A single strand of recombinant nucleic acid is encapsidated by bacteriophage proteins. The recombinant nucleic acid is a hybrid sequence encoding bacteriophage proteins and a specific non-bacteriophage sequence. A non-bacteriophage RNA sequence can be used as an RNA standard to help quantify the number of RNA molecules in an unknown sample. The recombinant RNA in its packaged form is highly resistant to ribonucleases, insuring that the RNA standard is not compromised by inadvertent ribonuclease contamination. These ARMORED RNA.TM. standards are ideal as RNA standards for the quantification of RNA viruses such as HIV and HCV from human body fluids such as blood and cerebrospinal fluid.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: July 6, 1999
    Assignees: Ambion, Inc., Cenetron Diagnostics, LLC
    Inventors: Dwight B. DuBois, Matthew M. Winkler, Brittan L. Pasloske
  • Ribonuclease resistant viral RNA standards
    Patent number: 5677124
    Abstract: The present invention is directed to the process of creating a recombinant nucleic acid standard which is resistant to ribonuclease digestion and is non-infectious. A single strand of recombinant nucleic acid is encapsidated by bacteriophage proteins. The recombinant nucleic acid is a hybrid sequence encoding bacteriophage proteins and a specific non-bacteriophage sequence. A non-bacteriophage RNA sequence can be used as an RNA standard to help quantify the number of RNA molecules in an unknown sample. The recombinant RNA in its packaged form is highly resistant to ribonucleases, insuring that the RNA standard is not compromised by inadvertent ribonuclease contamination. These "ARMORED RNA" standards are ideal as RNA standards for the quantification of RNA viruses such as HIV and HCV from human body fluids such as blood and cerebrospinal fluid.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: October 14, 1997
    Assignees: Ambion, Inc., Cenetron Diagnostics LLC
    Inventors: Dwight B. DuBois, Matthew M. Winkler, Brittan L. Pasloske