Patents Assigned to Cenix Bioscience GmbH
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Patent number: 8507546Abstract: The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.Type: GrantFiled: July 13, 2012Date of Patent: August 13, 2013Assignees: Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Cenix Bioscience GmbHInventors: Michael Hannus, Cecilie Martin, Maria M. Mota, Miguel Prudencio, Christina Dias Rodrigues
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Publication number: 20120276121Abstract: The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.Type: ApplicationFiled: July 13, 2012Publication date: November 1, 2012Applicants: INSTITUTO DE MEDICINA MOLECULAR, FACULDADE DE MEDICINA DA UNIVERSIDADE DE LISBOA, CENIX BIOSCIENCE GMBHInventors: MICHAEL HANNUS, CECILIE MARTIN, MARIA M. MOTA, MIGUEL PRUDENCIO, CHRISTINA DIAS RODRIGUES
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Publication number: 20120258104Abstract: The present invention relates to a delivery system that comprises a conjugate that facilitates the delivery of a compound such as a biologically-active macromolecule, a nucleic acid or a peptide in particular, into a cell. The present invention also relates to said conjugate for delivery of a compound, such as a biologically-active macromolecule, a nucleic acid or a peptide, into a cell. The present invention further relates to a pharmaceutical composition comprising said conjugate and to its use. The present invention also relates to a method of delivering a compound to a cell or an organism, preferably a patient.Type: ApplicationFiled: July 22, 2010Publication date: October 11, 2012Applicant: Cenix Bioscience GMBHInventors: Christophe J. Echeverri, Birte Sonnichsen, Reinhard Wähler, Mike Werner Helms
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Patent number: 7648827Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.Type: GrantFiled: September 15, 2004Date of Patent: January 19, 2010Assignee: Cenix BioScience GmbHInventors: Christophe Echeverri, Anthony Hyman, Pierre Gönczy, Birte Sönnichsen, Steven Jones, Andrew Walsh, Liisa Koski
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Publication number: 20090324580Abstract: The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.Type: ApplicationFiled: March 9, 2007Publication date: December 31, 2009Applicants: CENIX BIOSCIENCE GMBH, INSTITUTO DE MEDICINA MOLECULAR , FACULDADE DE MEDICINA DA UNIVERSIDADA DE LISBOAInventors: Michael Hannus, Cecilie Martin, Maria M. Mota, Miguel Prudencio, Christina Dias Rodrigues
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Publication number: 20090214477Abstract: The invention relates to novel targets in the screening for compounds useful in the treatment and/or prophylaxis of a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention relates to novel compounds for use as a medicament for diseases or conditions involving a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention especially relates to antagonists and expression-inhibitory compounds that target G-protein coupled receptors (GPCRs), kinases and proteases, and to methods for identifying such compounds. The invention further relates to methods for identifying these antagonists and expression-inhibitory compounds, and methods for diagnosing a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis or a susceptibility to such a condition.Type: ApplicationFiled: April 8, 2006Publication date: August 27, 2009Applicant: Cenix BioScience GmbHInventors: Ulrich Betz, Donatella D'Urso, Peter Kolkhof, Michael Seewald, Jochen Strayle, Anne Plötner, Michael Hannus
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Patent number: 7479369Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in spindle formation or microtubule function during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.Type: GrantFiled: September 15, 2004Date of Patent: January 20, 2009Assignee: Cenix BioScience GmbHInventors: Christophe Echeverri, Anthony Hyman, Pierre Gönczy, Birte Sönnichsen, Steven Jones, Andrew Walsh, Liisa Koski
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Patent number: 7368248Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell division and proliferation processes that could be identified by means of RNA-medicated interference (RNAi) and to the identification and isolation of functional orthologues of said genes including all biologically-active derivatives thereof. The invention further relates to the use of said gene products (including said orthologues) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative diseases.Type: GrantFiled: November 9, 2001Date of Patent: May 6, 2008Assignee: Cenix Bioscience GmbHInventors: Christophe Echeverri, Pierre Goenczy, Anthony Hyman, Steven Jones, Karen Oegema, Matthew Kirkham
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Publication number: 20070093438Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in spindle formation or microtubule function during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.Type: ApplicationFiled: September 15, 2004Publication date: April 26, 2007Applicant: Cenix BioScience GMbHInventors: Christophe Echeverri, Anthony Hyman, Pierre Gonczy, Birte Sonnichsen, Steven Jones, Andrew Walsh, Liisa Koski
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Publication number: 20070042981Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in chromatin separation during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.Type: ApplicationFiled: September 15, 2004Publication date: February 22, 2007Applicant: Cenix BioScience GmbHInventors: Christophe Echeverri, Anthony Hyman, Pierre Gonczy, Birte Sonnichsen, Steven Jones, Andrew Walsh, Liisa Koski
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Publication number: 20070015161Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.Type: ApplicationFiled: September 15, 2004Publication date: January 18, 2007Applicant: Cenix BioScience GmbHInventors: Christophe Echeverri, Anthony Hynan, Pierry Gonczy, Birte Sonnichsen, Steven Jones, Andrew Walsh, Liisa Koski