Abstract: An improved process for preparation of triazol-benzodiazepine derivatives, such as alprazolam, triazolam, brotizolam and etizolam, is presented. The process comprises a cyclization reaction of compound Formula B in toluene with catalytic amount of p-toluene sulphonic acid to obtain the triazol-benzodiazepine derivative of Formula C: wherein R is, and X is hydrogen or halogen.
Type:
Grant
Filed:
August 19, 2008
Date of Patent:
January 31, 2012
Assignee:
Centaur Chemicals Pvt Ltd
Inventors:
Anil M. Naik, Shrikant D. Sawant, Girish A. Kavishwar, Smita G. Kavishwar
Abstract: An improved process for preparation of triazol-benzodiazepine derivatives, such as alprazolam, triazolam, brotizolam and etizolam, is presented. The process comprises a cyclization reaction of compound Formula B in toluene with catalytic amount of p-toluene sulphonic acid to obtain the triazol-benzodiazepine derivative of Formula C: wherein R is, and X is hydrogen or halogen.
Type:
Application
Filed:
August 19, 2008
Publication date:
April 9, 2009
Applicant:
Centaur Chemicals Pvt Ltd
Inventors:
Anil M. Naik, Shrikant D. Sawant, Girish A. Kavishwar, Smita G. Kavishwar